ID G0U4B5_TRYVY Unreviewed; 817 AA.
AC G0U4B5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Glucosidase II subunit alpha {ECO:0000256|ARBA:ARBA00042895};
GN ORFNames=TVY486_1013210 {ECO:0000313|EMBL:CCC52278.1};
OS Trypanosoma vivax (strain Y486).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Duttonella.
OX NCBI_TaxID=1055687 {ECO:0000313|EMBL:CCC52278.1};
RN [1] {ECO:0000313|EMBL:CCC52278.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Y486 {ECO:0000313|EMBL:CCC52278.1};
RX PubMed=22331916; DOI=10.1073/pnas.1117313109;
RA Jackson A.P., Berry A., Aslett M., Allison H.C., Burton P.,
RA Vavrova-Anderson J., Brown R., Browne H., Corton N., Hauser H., Gamble J.,
RA Gilderthorp R., Marcello L., McQuillan J., Otto T.D., Quail M.A.,
RA Sanders M.J., van Tonder A., Ginger M.L., Field M.C., Barry J.D.,
RA Hertz-Fowler C., Berriman M.;
RT "Antigenic diversity is generated by distinct evolutionary mechanisms in
RT African trypanosome species.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:3416-3421(2012).
CC -!- PATHWAY: Glycan metabolism; N-glycan metabolism.
CC {ECO:0000256|ARBA:ARBA00004833}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 31 family.
CC {ECO:0000256|ARBA:ARBA00007806, ECO:0000256|RuleBase:RU361185}.
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DR EMBL; HE573026; CCC52278.1; -; Genomic_DNA.
DR AlphaFoldDB; G0U4B5; -.
DR VEuPathDB; TriTrypDB:TvY486_1013210; -.
DR OrthoDB; 5480935at2759; -.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0032450; F:maltose alpha-glucosidase activity; IEA:UniProtKB-EC.
DR CDD; cd06603; GH31_GANC_GANAB_alpha; 1.
DR CDD; cd14752; GH31_N; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.1760; glycosyl hydrolase (family 31); 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 2.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR048395; Glyco_hydro_31_C.
DR InterPro; IPR025887; Glyco_hydro_31_N_dom.
DR InterPro; IPR000322; Glyco_hydro_31_TIM.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR22762; ALPHA-GLUCOSIDASE; 1.
DR PANTHER; PTHR22762:SF54; BCDNA.GH04962; 1.
DR Pfam; PF13802; Gal_mutarotas_2; 1.
DR Pfam; PF01055; Glyco_hydro_31_2nd; 1.
DR Pfam; PF21365; Glyco_hydro_31_3rd; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|RuleBase:RU361185, ECO:0000313|EMBL:CCC52278.1};
KW Hydrolase {ECO:0000256|RuleBase:RU361185, ECO:0000313|EMBL:CCC52278.1};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..817
FT /note="Glucosidase II subunit alpha"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003410407"
FT DOMAIN 128..205
FT /note="Glycoside hydrolase family 31 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13802"
FT DOMAIN 248..584
FT /note="Glycoside hydrolase family 31 TIM barrel"
FT /evidence="ECO:0000259|Pfam:PF01055"
FT DOMAIN 592..678
FT /note="Glycosyl hydrolase family 31 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21365"
SQ SEQUENCE 817 AA; 92966 MW; 7D2D724EB2C91584 CRC64;
MVATLLCASG QRLMSVLVFV LLLMGASCGQ EISKVNSNFV ADVSHYGDGI MRLVLKPTSD
WFYQVESVIM RDAVGGTLNS TCSGTSCITY SKHCTLRTST EAEKFTASYQ CNDIELSTVK
IALQNMESPT VHLSFPTSRR LYGIPEHAMD LTLKGNTTYS MYNTDAFQYR INDPQPLYGS
IPFLLAHSKE ASTGILFLNS AGMKVEVVTE GILGCKWSTE AGLVDLFFFP GSTPALVQQQ
HASITGNTAM PPYFSLGYHQ CRWNYRSTDD CLAVDQGFDK HNLPYDVLWL DIEHTDNKKY
FTWDKYVFPD PKALVESLVA KGRKLVTIKD PHVKVEDGYY VHDEATKGDY YIKDSSGESP
YRAQCWPGRS SWVDFYNKRA RDWYATLFRH DRYEAGSHDV HSWVDMNEPS VFEGPEKTIH
RDAKHVSDSG KLVENRYIHN MYSLYNVMAV HQGHIESSRG LPYVMRPFIL TRSFFSGSQR
YAAMWTGDNM AKWDHLQNSF PELLSLSVSN YVFVGADIGG FFFDPSEELF VRWMQAGVFY
PFMRSHSHLE TKRREPWVYG EVATDRIRAA LALRYSLVPY LYTQFLHSHK NGTIIMRPLF
YEFPHEESFY DEQYTFMFGP SLLVSPVLNP GEQEKSIPIP SGSKWYSYST GEVVPPGSFR
MPVDMDTIPM FIRGGHIIPA KLRMRRATFS TKQDPFTLYV ALNDQGNSVG DLFIDDGETF
NFEHGGFIHR RFALTHDRLT SSPFPGTSKS LTFTVTNRVE RIVIFGFQGK PEKVLVEEIK
GHVATGREIE FEIQGGSLIL RNPDVLVSDD WSIFLKR
//
