ID   G0UJJ5_TRYCI            Unreviewed;       486 AA.
AC   G0UJJ5;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=RNA polymerase II-associated protein 3 {ECO:0000256|ARBA:ARBA00040133};
GN   ORFNames=TCIL3000_2_1260 {ECO:0000313|EMBL:CCC89548.1};
OS   Trypanosoma congolense (strain IL3000).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Nannomonas.
OX   NCBI_TaxID=1068625 {ECO:0000313|EMBL:CCC89548.1};
RN   [1] {ECO:0000313|EMBL:CCC89548.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=IL3000 {ECO:0000313|EMBL:CCC89548.1};
RX   PubMed=22331916; DOI=10.1073/pnas.1117313109;
RA   Jackson A.P., Berry A., Aslett M., Allison H.C., Burton P.,
RA   Vavrova-Anderson J., Brown R., Browne H., Corton N., Hauser H., Gamble J.,
RA   Gilderthorp R., Marcello L., McQuillan J., Otto T.D., Quail M.A.,
RA   Sanders M.J., van Tonder A., Ginger M.L., Field M.C., Barry J.D.,
RA   Hertz-Fowler C., Berriman M.;
RT   "Antigenic diversity is generated by distinct evolutionary mechanisms in
RT   African trypanosome species.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:3416-3421(2012).
CC   -!- SIMILARITY: Belongs to the RPAP3 family.
CC       {ECO:0000256|ARBA:ARBA00038275}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HE575315; CCC89548.1; -; Genomic_DNA.
DR   AlphaFoldDB; G0UJJ5; -.
DR   VEuPathDB; TriTrypDB:TcIL3000_2_1260; -.
DR   OrthoDB; 1430075at2759; -.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR025986; RPAP3-like_C.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR46423; RNA POLYMERASE II-ASSOCIATED PROTEIN 3; 1.
DR   PANTHER; PTHR46423:SF1; RNA POLYMERASE II-ASSOCIATED PROTEIN 3; 1.
DR   Pfam; PF13877; RPAP3_C; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50005; TPR; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW   ProRule:PRU00339}.
FT   REPEAT          75..108
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   DOMAIN          371..456
FT                   /note="RNA-polymerase II-associated protein 3-like C-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13877"
FT   REGION          219..242
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          301..335
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          7..34
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        222..238
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        311..335
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   486 AA;  54231 MW;  ACACF986FB8CCC28 CRC64;
     MDYAAAIKQQ ADDLQDELKE LALWQEEVVR QQETNPKKRV DPFAVGTVPP IRGTVPSLKD
     AVMKSANVVE KEDPVKLQKD KGNNLFQNGR LEEAIDAYGV GIDIDPNGQT AHVLFCNRAL
     CYLKLNRWAD AERDASSCVR LNRTYPKGYF RRAMARKHLG NLKGARVDLE AVLALLPNDT
     SATNEIKLIT KMLQTERESG VPVVRKKIAI MEVDEEEQDV GDNTCSNTVS SSQTNKREEP
     CTEGIKSGEV RKEIAELERA RVACLDARDA KSREAEAKVQ LGRRASSRVE VLDEDIKGYE
     KEKEETFSPP LSKNVARQSE AAQDQATKEQ PAYSTGVVRT QTVRNTKQEA VTSVRALKTA
     PKWSKETLKM PKSFTEFERV FSDLGDDEDL RCFYISIIPP GSMRELFGSN MTPEILFGML
     KAARRLPGTA VAVFLRGLCT VRRVEDISLF FDGAERKVAK EVIDIVVSCG ASQQDINLFA
     QRLGVL
//