ID   G0W9B5_NAUDC            Unreviewed;       916 AA.
AC   G0W9B5;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   RecName: Full=ERAD-associated E3 ubiquitin-protein ligase component HRD3 {ECO:0008006|Google:ProtNLM};
GN   Name=NDAI0D00620 {ECO:0000313|EMBL:CCD24376.1};
GN   OrderedLocusNames=NDAI_0D00620 {ECO:0000313|EMBL:CCD24376.1};
OS   Naumovozyma dairenensis (strain ATCC 10597 / BCRC 20456 / CBS 421 / NBRC
OS   0211 / NRRL Y-12639) (Saccharomyces dairenensis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Naumovozyma.
OX   NCBI_TaxID=1071378 {ECO:0000313|EMBL:CCD24376.1, ECO:0000313|Proteomes:UP000000689};
RN   [1] {ECO:0000313|EMBL:CCD24376.1, ECO:0000313|Proteomes:UP000000689}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10597 / BCRC 20456 / CBS 421 / NBRC 0211 / NRRL Y-12639
RC   {ECO:0000313|Proteomes:UP000000689};
RX   PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA   Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA   Wolfe K.H.;
RT   "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT   accidents.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC   -!- SIMILARITY: Belongs to the sel-1 family.
CC       {ECO:0000256|ARBA:ARBA00038101}.
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DR   EMBL; HE580270; CCD24376.1; -; Genomic_DNA.
DR   RefSeq; XP_003669619.1; XM_003669571.1.
DR   AlphaFoldDB; G0W9B5; -.
DR   STRING; 1071378.G0W9B5; -.
DR   GeneID; 11494930; -.
DR   KEGG; ndi:NDAI_0D00620; -.
DR   eggNOG; KOG1550; Eukaryota.
DR   HOGENOM; CLU_348239_0_0_1; -.
DR   OMA; LALICHY; -.
DR   OrthoDB; 1378605at2759; -.
DR   Proteomes; UP000000689; Chromosome 4.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   InterPro; IPR006597; Sel1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR11102:SF147; FIBRONECTIN TYPE-II DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR11102; SEL-1-LIKE PROTEIN; 1.
DR   Pfam; PF08238; Sel1; 5.
DR   SMART; SM00671; SEL1; 4.
DR   SUPFAM; SSF81901; HCP-like; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000689};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           32..916
FT                   /note="ERAD-associated E3 ubiquitin-protein ligase
FT                   component HRD3"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003411217"
FT   TRANSMEM        847..866
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          880..901
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   916 AA;  104916 MW;  1809A85EA144BA3D CRC64;
     MRKPIISVTN CYTCILIFVL ILVPFLSFTA AAQEEVQQQQ QYEEQLVGQQ LEDPWNYEIQ
     SLIEQLPPIS DPLNPSLSSS SSNNTLSRRD NLYDKSFYLP MDYSIENEEI ISNQFWSKNI
     TNLQSKLYDS LLISSENFNN VQSTYLLSQI HLYGKFGFPQ NKSEAHKTLL KFNQLTNFNN
     HTALFDLAMM YSTGLFGTIP IDISKSLIYF QKSASLGNLM AKQVMAYKYY MGLNVPRDFN
     KALLLYNEIS TTLRTISPTS YFKFLHWDIN FPDLETFQVR ILDFNKKNFG LLGKGLSSVA
     SSITRRKAIR PDITSSVLTQ MNPGGQIVLQ FGLGADINSF SLSENDDRNE DDVYDEDQLV
     DLFYTAWDLY KGTYTQLRDV PQAKRILEKI IKDYENDVDF MDNLQRFFFS KSLDLLGHIY
     FMGEHIETPP NEDPKPDLNI AIHYLERAVK VLETSTVVKS RANVDLALIC HYAENNIPKA
     LGFYNKMVDS RYNNGNIDYQ LSKLAKEHPD LKNLGDPMVH LQNAFMKRYP PAVYDYAKML
     ESGVNGKYNV EETTYIYKAF AEEMEPIMAP HLQNAFRQLL LGNIEIALWE YSKAAEQGYE
     TAQVSAASLM YQTPFKFEPN PTTTPERKNM AITYFSRAFK QNNVDAGVVA GDIYYDMGQF
     DKAISIYQSA ALKMSPQAVW DLGYMYEHGL GVPKDIHLAK RYYDQILEIN HKLFIASKLS
     VWKLQFNIWI DWLKETKIYK LFIKLILNRI KLRTTNIPFV DMMNPIIPIK QSHMVHNYTN
     KLKSFIFQET KYLTTSVNVN SNTTIISRPP RKIIVQPGLE SLRGINGEQH ADDESFFSSL
     GLNTEDLLTM GLILFMFLMT IVLRIVGPRQ DWNIGINGIP IQRDQDDREG QDGGNAGAPR
     GAGGIFGNLD IQVVAI
//