ID G0XAD8_ECOLX Unreviewed; 235 AA.
AC G0XAD8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 79.
DE RecName: Full=Thiol:disulfide interchange protein {ECO:0000256|RuleBase:RU364038};
GN Name=dsbC {ECO:0000313|EMBL:ADM62476.1};
GN Synonyms=dsbc {ECO:0000313|EMBL:AGW01059.1};
GN ORFNames=C3F40_30730 {ECO:0000313|EMBL:AUY05943.1}, pPG010208_83
GN {ECO:0000313|EMBL:ADM62476.1}, pSCEC2_034
GN {ECO:0000313|EMBL:AGW01059.1}, RCS1TR83_P0156
GN {ECO:0000313|EMBL:SPD95408.1}, RCS24TR548_P0146
GN {ECO:0000313|EMBL:SPD95762.1}, RCS30_P0146
GN {ECO:0000313|EMBL:SPD96202.1}, RCS38_P0133
GN {ECO:0000313|EMBL:SPD98458.1}, RCS46_P0118
GN {ECO:0000313|EMBL:SPD98693.1};
OS Escherichia coli.
OG Plasmid RCS1TR83_p {ECO:0000313|EMBL:SPD95408.1},
OG Plasmid RCS24TR548_p {ECO:0000313|EMBL:SPD95762.1},
OG Plasmid RCS30_p {ECO:0000313|EMBL:SPD96202.1},
OG Plasmid RCS38_p {ECO:0000313|EMBL:SPD98458.1},
OG Plasmid RCS46_p {ECO:0000313|EMBL:SPD98693.1},
OG Plasmid p39R861-4 {ECO:0000313|EMBL:AJT60234.1},
OG Plasmid pBK32533 {ECO:0000313|EMBL:AKA87235.1},
OG Plasmid pECO-c85f {ECO:0000313|EMBL:AUY05943.1},
OG Plasmid pEc158 {ECO:0000313|EMBL:ASF80908.1},
OG Plasmid pPG010208 {ECO:0000313|EMBL:ADM62476.1},
OG Plasmid pSCEC2 {ECO:0000313|EMBL:AGW01059.1}, and
OG Plasmid peco-c85f {ECO:0000313|Proteomes:UP000239554}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=562 {ECO:0000313|EMBL:ADM62476.1};
RN [1] {ECO:0000313|EMBL:ADM62476.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PG010208 {ECO:0000313|EMBL:ADM62476.1};
RC PLASMID=pPG010208 {ECO:0000313|EMBL:ADM62476.1};
RA Fernandez-Alarcon C.L., Johnson T.J., Nolan L.K., Singer R.S.;
RL Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ADM62476.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PG010208 {ECO:0000313|EMBL:ADM62476.1};
RC PLASMID=pPG010208 {ECO:0000313|EMBL:ADM62476.1};
RX PubMed=21858108; DOI=10.1371/journal.pone.0023415;
RA Fernandez-Alarcon C., Singer R.S., Johnson T.J.;
RT "Comparative Genomics of Multidrug Resistance-Encoding IncA/C Plasmids from
RT Commensal and Pathogenic Escherichia coli from Multiple Animal Sources.";
RL PLoS ONE 6:E23415-E23415(2011).
RN [3] {ECO:0000313|EMBL:AGW01059.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SCEC2 {ECO:0000313|EMBL:AGW01059.1};
RC PLASMID=pSCEC2 {ECO:0000313|EMBL:AGW01059.1};
RA Zhang W., Xu X., Schwarz S., Wang X., Dai L., Zheng H., Liu S.;
RL Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AGW01059.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SCEC2 {ECO:0000313|EMBL:AGW01059.1};
RC PLASMID=pSCEC2 {ECO:0000313|EMBL:AGW01059.1};
RX PubMed=24013193; DOI=10.1093/jac/dkt355;
RA Zhang W.J., Xu X.R., Schwarz S., Wang X.M., Dai L., Zheng H.J., Liu S.;
RT "Characterization of the IncA/C plasmid pSCEC2 from Escherichia coli of
RT swine origin that harbours the multiresistance gene cfr.";
RL J. Antimicrob. Chemother. 69:385-389(2014).
RN [5] {ECO:0000313|EMBL:AKA87235.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BK32533 {ECO:0000313|EMBL:AKA87235.1};
RC PLASMID=pBK32533 {ECO:0000313|EMBL:AKA87235.1};
RX PubMed=25753632; DOI=10.1128/AAC.00041-15;
RA Chavda K.D., Chen L., Jacobs M.R., Rojtman A.D., Bonomo R.A.,
RA Kreiswirth B.N.;
RT "Complete Sequence of a blaKPC-Harboring Cointegrate Plasmid Isolated from
RT Escherichia coli.";
RL Antimicrob. Agents Chemother. 59:2956-2959(2015).
RN [6] {ECO:0000313|EMBL:AJT60234.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=39R861 {ECO:0000313|EMBL:AJT60234.1};
RC PLASMID=p39R861-4 {ECO:0000313|EMBL:AJT60234.1};
RX PubMed=26167918; DOI=10.1089/mdr.2015.0133;
RA Anantham S., Harmer C.J., Hall R.M.;
RT "p39R861-4, A Type 2?A/C2 Plasmid Carrying a Segment from the A/C1 Plasmid
RT RA1.";
RL Microb. Drug Resist. 21:571-576(2015).
RN [7] {ECO:0000313|EMBL:ASF80908.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Ec158 {ECO:0000313|EMBL:ASF80908.1};
RC PLASMID=pEc158 {ECO:0000313|EMBL:ASF80908.1};
RA Papagiannitsis C.C., Dolejska M.;
RT "Characterization of IncA/C2 plasmids, encoding IMP-like metallo-beta-
RT lactamases, recovered from silver gulls in Australia.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:AUY05943.1, ECO:0000313|Proteomes:UP000239554}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ECONIH4 {ECO:0000313|EMBL:AUY05943.1,
RC ECO:0000313|Proteomes:UP000239554};
RC PLASMID=peco-c85f {ECO:0000313|Proteomes:UP000239554}, and pECO-c85f
RC {ECO:0000313|EMBL:AUY05943.1};
RX PubMed=29437920;
RG NISC Comparative Sequencing Program;
RA Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P.,
RA Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J.,
RA Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.;
RT "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of
RT Bacterial Plasmids Conferring Carbapenem Resistance.";
RL MBio 9:e02011-e02017(2018).
RN [9] {ECO:0000313|EMBL:AUY05943.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ECONIH4 {ECO:0000313|EMBL:AUY05943.1};
RC PLASMID=pECO-c85f {ECO:0000313|EMBL:AUY05943.1};
RG NISC Comparative Sequencing Program;
RA Weingarten R.A., Johnson R.C., Conlan S., Ramsburg A.M., Dekker J.P.,
RA Lau A.F., Khil P., Odom R.T., Deming C., Park M., Thomas P.J.,
RA Henderson D.K., Palmore T.N., Segre J.A., Frank K.M.;
RT "Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of
RT Bacterial Plasmids Conferring Carbapenem Resistance.";
RL MBio 9:0-0(2018).
RN [10] {ECO:0000313|EMBL:SPD95408.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=170 {ECO:0000313|EMBL:SPD98458.1}, 195
RC {ECO:0000313|EMBL:SPD98693.1}, 513 {ECO:0000313|EMBL:SPD96202.1}, and
RC 83 {ECO:0000313|EMBL:SPD95408.1};
RC PLASMID=RCS1TR83_p {ECO:0000313|EMBL:SPD95408.1}, RCS30_p
RC {ECO:0000313|EMBL:SPD96202.1}, RCS38_p {ECO:0000313|EMBL:SPD98458.1},
RC and RCS46_p {ECO:0000313|EMBL:SPD98693.1};
RA Cohen D.B., Kent A.D.;
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
RN [11] {ECO:0000313|EMBL:SPD95762.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=548 {ECO:0000313|EMBL:SPD95762.1};
RC PLASMID=RCS24TR548_p {ECO:0000313|EMBL:SPD95762.1};
RA Cea G.-C., William W.;
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for disulfide bond formation in some periplasmic
CC proteins. Acts by transferring its disulfide bond to other proteins and
CC is reduced in the process. {ECO:0000256|RuleBase:RU364038}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000256|ARBA:ARBA00004418,
CC ECO:0000256|RuleBase:RU364038}.
CC -!- SIMILARITY: Belongs to the thioredoxin family. DsbC subfamily.
CC {ECO:0000256|ARBA:ARBA00009813, ECO:0000256|RuleBase:RU364038}.
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DR EMBL; HQ023861; ADM62476.1; -; Genomic_DNA.
DR EMBL; KF152885; AGW01059.1; -; Genomic_DNA.
DR EMBL; KP276584; AJT60234.1; -; Genomic_DNA.
DR EMBL; KP345882; AKA87235.1; -; Genomic_DNA.
DR EMBL; KY887596; ASF80908.1; -; Genomic_DNA.
DR EMBL; CP026405; AUY05943.1; -; Genomic_DNA.
DR EMBL; LT985220; SPD95408.1; -; Genomic_DNA.
DR EMBL; LT985222; SPD95762.1; -; Genomic_DNA.
DR EMBL; LT985224; SPD96202.1; -; Genomic_DNA.
DR EMBL; LT985250; SPD98458.1; -; Genomic_DNA.
DR EMBL; LT985249; SPD98693.1; -; Genomic_DNA.
DR RefSeq; WP_001259347.1; NZ_WUBH01000020.1.
DR RefSeq; YP_006952781.1; NC_019065.1.
DR RefSeq; YP_008575014.1; NC_022377.1.
DR GeneID; 84568420; -.
DR Proteomes; UP000239554; Plasmid peco-c85f.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR CDD; cd03020; DsbA_DsbC_DsbG; 1.
DR Gene3D; 3.10.450.70; Disulphide bond isomerase, DsbC/G, N-terminal; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR033954; DiS-bond_Isoase_DsbC/G.
DR InterPro; IPR018950; DiS-bond_isomerase_DsbC/G_N.
DR InterPro; IPR009094; DiS-bond_isomerase_DsbC/G_N_sf.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR35272:SF3; THIOL:DISULFIDE INTERCHANGE PROTEIN DSBC; 1.
DR PANTHER; PTHR35272; THIOL:DISULFIDE INTERCHANGE PROTEIN DSBC-RELATED; 1.
DR Pfam; PF10411; DsbC_N; 1.
DR Pfam; PF13098; Thioredoxin_2; 1.
DR SUPFAM; SSF54423; DsbC/DsbG N-terminal domain-like; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000313|EMBL:SPD95408.1};
KW Periplasm {ECO:0000256|ARBA:ARBA00022764, ECO:0000256|RuleBase:RU364038};
KW Plasmid {ECO:0000313|EMBL:ADM62476.1};
KW Redox-active center {ECO:0000256|RuleBase:RU364038};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU364038}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|RuleBase:RU364038"
FT CHAIN 22..235
FT /note="Thiol:disulfide interchange protein"
FT /evidence="ECO:0000256|RuleBase:RU364038"
FT /id="PRO_5015019674"
FT DOMAIN 24..76
FT /note="Disulphide bond isomerase DsbC/G N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10411"
FT DOMAIN 110..218
FT /note="Thioredoxin-like fold"
FT /evidence="ECO:0000259|Pfam:PF13098"
SQ SEQUENCE 235 AA; 25832 MW; 9A23B2CF568608B9 CRC64;
MRTKLLGALM VFGIITGTAH ASSKLEITDP RAAKIEDIVE LPIKGVRAVQ SDGQIMFLSE
NGRFVISGQI YDLWSKKPLN TMSQMRDVAE RIHFKSMGMD VDTLNTVSMG RGDKEVVVFV
DPRCAVCHQL MGDAKSLVDD YTFKFIVIPA LGAESNRLAK NLYCAKDKTH ALDALMNNTL
GSLPSKETCD PGQYDQTLLT AHFIGIEGVP FVVAPDGRVS KGRPKNLKSW LESVE
//
