ID   G0XY31_STAAU            Unreviewed;       558 AA.
AC   G0XY31;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   24-JAN-2024, entry version 45.
DE   SubName: Full=Clumping factor A {ECO:0000313|EMBL:AEK94102.1};
DE   Flags: Fragment;
GN   Name=clfA {ECO:0000313|EMBL:AEK94102.1};
OS   Staphylococcus aureus.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280 {ECO:0000313|EMBL:AEK94102.1};
RN   [1] {ECO:0000313|EMBL:AEK94102.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=H291 {ECO:0000313|EMBL:AEK94102.1};
RX   PubMed=21245656;
RA   Murphy E., Lin S.L., Nunez L., Andrew L., Fink P.S., Dilts D.A.,
RA   Hoiseth S.K., Jansen K.U., Anderson A.S.;
RT   "Challenges for the evaluation of Staphylococcus aureus protein based
RT   vaccines: Monitoring antigenic diversity.";
RL   Hum. Vaccin. 7:51-59(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC       {ECO:0000256|ARBA:ARBA00004168}; Peptidoglycan-anchor
CC       {ECO:0000256|ARBA:ARBA00004168}.
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DR   EMBL; HQ424272; AEK94102.1; -; Genomic_DNA.
DR   AlphaFoldDB; G0XY31; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   Gene3D; 2.60.40.1280; -; 1.
DR   Gene3D; 2.60.40.1290; -; 1.
DR   InterPro; IPR011266; Adhesin_Fg-bd_dom_2.
DR   InterPro; IPR008966; Adhesion_dom_sf.
DR   InterPro; IPR011252; Fibrogen-bd_dom1.
DR   InterPro; IPR041171; SDR_Ig.
DR   InterPro; IPR005877; YSIRK_signal_dom.
DR   NCBIfam; NF033609; MSCRAMM_ClfA; 1.
DR   NCBIfam; TIGR01168; YSIRK_signal; 1.
DR   Pfam; PF17961; Big_8; 1.
DR   Pfam; PF10425; SdrG_C_C; 1.
DR   Pfam; PF04650; YSIRK_signal; 1.
DR   SUPFAM; SSF49401; Bacterial adhesins; 2.
PE   4: Predicted;
KW   Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW   Peptidoglycan-anchor {ECO:0000256|ARBA:ARBA00023088};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          4..27
FT                   /note="YSIRK Gram-positive signal peptide"
FT                   /evidence="ECO:0000259|Pfam:PF04650"
FT   DOMAIN          249..348
FT                   /note="SDR-like Ig"
FT                   /evidence="ECO:0000259|Pfam:PF17961"
FT   DOMAIN          374..524
FT                   /note="Fibrinogen-binding"
FT                   /evidence="ECO:0000259|Pfam:PF10425"
FT   REGION          34..198
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          528..558
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..198
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         558
FT                   /evidence="ECO:0000313|EMBL:AEK94102.1"
SQ   SEQUENCE   558 AA;  59364 MW;  8B8B9500049EA197 CRC64;
     MNMKKKEKHA IRKKSIGVAS VLVGTLIGFG LLSSKEADAS ENSVTQSDSA SNESKSNDSS
     SVSAAPKTDD TNVSDTKTSS NTNNGETSVA QNPAQQETTQ SALTNATTEE TPVTGEATTA
     TNQANTPATT QSSNTNAEEL VNQTSNETTS NDTNTVSSVN SPQNSTNAEN VSTTQDTSTE
     ATPSNNESAP QNTDASNKDV VNQAVNTSAP RKRAFSLAAV AADAPAAGTD ITNQLTDVKV
     TIDSGTTVYP HQAGYVKLNY GFSVPNSAVK GDTFKITVPK ELNLNGVTST AKAPPIMAGD
     QVLANGVIDS DGNVIYTFTD YVDNKENVTA NITMPAYIDP ENVTKTGNVT LTTGIGTNTA
     SKTVLIDYEK YGQFHNLSIK GTIDQIDKTN NTYRQTIYVN PSGDNVVLPA LTGNLIPNTK
     SNALIDAKNT DIKVYRVDNA NDLSESYYVN PSDFEDVTNQ VRISFPNANQ YKVEFPTDDD
     QITTPYIVVV NGHIDPASTG DLALRSTFYG YDSNFIWRSM SWDNEVAFNN GSGSGDGIDK
     PVVPEQPDEP GEIEPIPE
//