ID G0XY95_STAAU Unreviewed; 542 AA.
AC G0XY95;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 13-SEP-2023, entry version 42.
DE SubName: Full=Clumping factor B {ECO:0000313|EMBL:AEK94166.1};
DE Flags: Fragment;
GN Name=clfB {ECO:0000313|EMBL:AEK94166.1};
OS Staphylococcus aureus.
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=1280 {ECO:0000313|EMBL:AEK94166.1};
RN [1] {ECO:0000313|EMBL:AEK94166.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GA-656 {ECO:0000313|EMBL:AEK94166.1};
RX PubMed=21245656;
RA Murphy E., Lin S.L., Nunez L., Andrew L., Fink P.S., Dilts D.A.,
RA Hoiseth S.K., Jansen K.U., Anderson A.S.;
RT "Challenges for the evaluation of Staphylococcus aureus protein based
RT vaccines: Monitoring antigenic diversity.";
RL Hum. Vaccin. 7:51-59(2011).
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall
CC {ECO:0000256|ARBA:ARBA00004168}; Peptidoglycan-anchor
CC {ECO:0000256|ARBA:ARBA00004168}.
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DR EMBL; HQ424344; AEK94166.1; -; Genomic_DNA.
DR AlphaFoldDB; G0XY95; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR Gene3D; 2.60.40.1280; -; 1.
DR Gene3D; 2.60.40.1290; -; 1.
DR InterPro; IPR011266; Adhesin_Fg-bd_dom_2.
DR InterPro; IPR008966; Adhesion_dom_sf.
DR InterPro; IPR011252; Fibrogen-bd_dom1.
DR InterPro; IPR041171; SDR_Ig.
DR InterPro; IPR005877; YSIRK_signal_dom.
DR NCBIfam; NF033845; MSCRAMM_ClfB; 1.
DR NCBIfam; TIGR01168; YSIRK_signal; 1.
DR Pfam; PF17961; Big_8; 1.
DR Pfam; PF10425; SdrG_C_C; 1.
DR Pfam; PF04650; YSIRK_signal; 1.
DR SUPFAM; SSF49401; Bacterial adhesins; 2.
PE 4: Predicted;
KW Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Peptidoglycan-anchor {ECO:0000256|ARBA:ARBA00023088};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 10..35
FT /note="YSIRK Gram-positive signal peptide"
FT /evidence="ECO:0000259|Pfam:PF04650"
FT DOMAIN 233..338
FT /note="SDR-like Ig"
FT /evidence="ECO:0000259|Pfam:PF17961"
FT DOMAIN 368..524
FT /note="Fibrinogen-binding"
FT /evidence="ECO:0000259|Pfam:PF10425"
FT REGION 44..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 542
FT /evidence="ECO:0000313|EMBL:AEK94166.1"
SQ SEQUENCE 542 AA; 59044 MW; CFFE992A325D1C86 CRC64;
MKKRIDYLSN KQNKYSIRRF TVGTTSVIVG ATILFGIGNH QAQASEQSND TTQSSKNNAS
ADSEKNNMIE TPQLNTTAND TSDISANTNS ANVDSTTKPM STQTSNTTTT EPASTNETPQ
PTAIKNQATA EKMQDQTVPQ EANSQVDNKT TNDANSIATN SELKNSQTLD LPQSSPQTIS
NAQGTSKPSV RTRAVRSLAV AEPVVNAADA KGTNVNDKVT ASNFKLEKTT FDPNQSGNTF
MAANFTVTDK VKSGDYFTAK LPDSLTGNGD VDYSNSNNTM PIADIKSTNG DVVAKATYDI
LTKTYTFVFT DYVNNKENIN GQFSLPLFTD RAKAPKSGTY DANINIADEM FNNKITYNYS
SPIAGIDKPN GANISSQIIG VDTASGQNTY KQTVFVNPKQ RVLGNTWVYI KGYQDKIEES
SGKVSATDTK LRIFEVNDTS KLSDSYYADP NDSNLKEVTD QFKNRIYYEH PNVASIKFGD
ITKTYVVLVE GHYDNTGKNL KTQVIQENVD PVTNRDYSIF GWNNENVVRY GGGSADGDSA
VN
//
