ID G0YYF8_SIV Unreviewed; 727 AA.
AC G0YYF8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:AEM17247.1};
OS Simian immunodeficiency virus (SIV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11723 {ECO:0000313|EMBL:AEM17247.1};
OH NCBI_TaxID=9527; Cercopithecidae (Old World monkeys).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:AEM17247.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=26719_21 {ECO:0000313|EMBL:AEM17247.1};
RA Stone M., Keele B.F., Wang Y., Dutra J., Miller C.J.;
RT "Multiple SIVenv variants are transmitted after vaginal SIVmac251
RT inoculation of rhesus macaques with experimentally induced genital
RT inflammation.";
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; HQ845632; AEM17247.1; -; Genomic_DNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 1.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:AEM17247.1};
KW Virion {ECO:0000313|EMBL:AEM17247.1}.
FT TRANSMEM 627..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..459
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 477..671
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 50..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 659..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 571..598
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 659..675
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEM17247.1"
FT NON_TER 727
FT /evidence="ECO:0000313|EMBL:AEM17247.1"
SQ SEQUENCE 727 AA; 83553 MW; 6EFA034D29B1246A CRC64;
ESFDAWENTV TEQAIEDVWQ LFETSIKPCV KLSPLCITMR CNKSETDKWG LTKSSTTTTA
TTATPASTTR TTSAKIDMVN ETSSCITHNN CTGLEQEQMI SCKFNMTGLK RDKKKEYNET
WYSTDLGCEQ GNSTDNESRC YMNHCNTSVI QESCDKHYWD TIRFRYCAPP GYALLRCNDT
NYSGFMPKCS KVVVSSCTRM METQTSTWFG FNGTRAENRT YIYWHGRDNR TIISLNKYYN
LTMKCRRPGN KTVLPVTIMS GLVFHSQPIN DRPKQAWCWF GGNWKDAIKE VKQTIVKHPR
YTGTNNTDKI NLTAPRGGDP EVTFMWTNCR GEFLYCKMNW FLNWVEDRNL TNKKSKEQHK
RNYVPCHIRQ IINTWHKVGK NVYLPPREGD LTCNSTVTSL IANIDWTDGN QTNITMSAEV
AELYRLELGD YKLVEITPIG LAPTDVKRYT TGGTSRNKRG VFVLGFLGFL ATAGSAMGAA
SLTLTAQSRT LLAGIVQQQQ QLLDVVKRQQ ELLRLTVWGT KNLQTRVTAI EKYLKDQAQL
NAWGCAFRQV CHTTVPWPNA SLTPDWNNDT WQEWERKVDF LEENITALLE EAQIQQEKNM
YELQKLNSWD VFGNWFDLAS WIRYIQYGIY IVVGVILLRI VIYIVQILAK LRQGYRPVFS
SPPSYSQQTH IQQDPALPTR EGKEGDGGEG GGNSSWPWQI EYIHFLIRQL IRLLTWLFSN
CRTLLSR
//
