ID G1K8N6_ANOCA Unreviewed; 749 AA.
AC G1K8N6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN Name=DHX15 {ECO:0000313|Ensembl:ENSACAP00000000629.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000000629.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000000629.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000000629.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000000629.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC DDX15/PRP43 sub-subfamily. {ECO:0000256|ARBA:ARBA00024333}.
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DR AlphaFoldDB; G1K8N6; -.
DR STRING; 28377.ENSACAP00000000629; -.
DR Ensembl; ENSACAT00000000649.4; ENSACAP00000000629.3; ENSACAG00000000412.4.
DR eggNOG; KOG0925; Eukaryota.
DR GeneTree; ENSGT00940000155800; -.
DR HOGENOM; CLU_001832_5_11_1; -.
DR InParanoid; G1K8N6; -.
DR TreeFam; TF105735; -.
DR Proteomes; UP000001646; Chromosome 5.
DR Bgee; ENSACAG00000000412; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR GO; GO:0005689; C:U12-type spliceosomal complex; IEA:Ensembl.
DR GO; GO:0071008; C:U2-type post-mRNA release spliceosomal complex; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
DR GO; GO:0004386; F:helicase activity; IBA:GO_Central.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0140374; P:antiviral innate immune response; IEA:Ensembl.
DR GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR CDD; cd17973; DEXHc_DHX15; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR044756; DHX15_DEXHc.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF95; ATP-DEPENDENT RNA HELICASE DHX15; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 114..280
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 305..472
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..58
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 749 AA; 86216 MW; 6A689D2CF7C8F294 CRC64;
MSKRHRLDLG DDYGSNKKRL ASDGKDRERD RDDRSKDRDR DRDRDRERER DKEKDLRPSA
NSALIAGVGV PALKPTVLPQ GINPFTNLPH TPRYYEILKK RLQLPVWEYK ERFTDILIRH
QSFVLVGETG SGKTTQIPQW CVDYMRSLPG PKRGVACTQP RRVAAMSVAQ RVADEMDVML
GQEVGYSIRF EDCSSAKTIL KYMTDGMLLR EAMNDPLLER YGVIILDEAH ERTLATDILM
GVLKEVVRQR SDLKVIVMSA TLDAGKFQIY FDNCPLLTIP GRTHPVEIFY TPEPERDYLE
AAIRTVIQIH MCEEEEGDLL LFLTGQEEID EACKRIKREI DDLGPEVGDI KIIPLYSTLP
PQQQQRIFEP PPPKKPNGAI GRKVSWNDFL SVFDSSVKQV YNPRIRVESL LVTAISKASA
QQRAGRAGRT RPGKCFRLYT EKAYKTEMQD NTYPEILRSN LGSVVLQLKK LGIDDLVHFD
FMDPPAPETL MRALELLNYL AALNDDGDLT ELGSMMAEFP LDPQLAKMVI ASCDYNCSNE
ILSITAMLSV PQCFVRPTEA KKAADEAKMR FAHIDGDHLT LLNVYHAFKQ NHESVQWCYD
NFINYRSLMS ADNVRQQLSR IMDRFNLPRR STDFTSRDYY INIRKALVTG YFMQVAHLER
TGHYLTVKDN QVVQLHPSTV LDHKPEWVLY NEFVLTTKNY IRTCTDIKPE WLVKIAPQYY
DMSNFPQCEA KRQLDRIIAK LQSKEYSQY
//
