ID G1K997_ANOCA Unreviewed; 354 AA.
AC G1K997;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=2-ketogluconate reductase {ECO:0008006|Google:ProtNLM};
GN Name=LOC100560052 {ECO:0000313|Ensembl:ENSACAP00000001203.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000001203.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000001203.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000001203.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000001203.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR RefSeq; XP_003219785.2; XM_003219737.3.
DR AlphaFoldDB; G1K997; -.
DR STRING; 28377.ENSACAP00000001203; -.
DR Ensembl; ENSACAT00000001236.4; ENSACAP00000001203.3; ENSACAG00000001320.4.
DR GeneID; 100560052; -.
DR KEGG; acs:100560052; -.
DR eggNOG; KOG0069; Eukaryota.
DR GeneTree; ENSGT00940000162740; -.
DR HOGENOM; CLU_019796_1_2_1; -.
DR InParanoid; G1K997; -.
DR OrthoDB; 6392at2759; -.
DR TreeFam; TF324791; -.
DR Proteomes; UP000001646; Chromosome 4.
DR Bgee; ENSACAG00000001320; Expressed in kidney and 8 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0030267; F:glyoxylate reductase (NADP+) activity; IBA:GO_Central.
DR GO; GO:0016618; F:hydroxypyruvate reductase activity; IBA:GO_Central.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR CDD; cd05301; GDH; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR PANTHER; PTHR10996:SF236; 2-KETOGLUCONATE REDUCTASE; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 49..352
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 142..321
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 354 AA; 39498 MW; 06A5DAE814C2F84E CRC64;
MPNCINFSDV GCRSVVFLFC NLFLTESMEE QELPYTLINV IGGLGGIYED HVEFLEKHLK
LIPMKDFLEN KETLRHKIQA VFVWMHKPVI NRELLQTLPN LKVIVNSGAG IDHFDLKLIF
SFGVKLANTP LAVTNATADL GMTLMLASAR RIVEGHQISV SPDTKHFRAD WLGEEVTGAT
LGIIGMGTIG YKVAQRAKAF EMKILYHNRN RRKEADEQAV GAHYCHKMEE LLQQSDFVML
VVNLTPQTHK LIGEKELKLM KPTATLINIC RGQVVDQDAL VNALQNGVIK AAALDVTYPE
PLPRDHPLLQ LKNCIITPHI GSATSQTRFL MMRNMVESVL AAVQGLPVPN EVQG
//
