ID G1KBS4_ANOCA Unreviewed; 657 AA.
AC G1KBS4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Anion exchange transporter {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Solute carrier family 26 member 7 {ECO:0000256|RuleBase:RU362052};
GN Name=SLC26A7 {ECO:0000313|Ensembl:ENSACAP00000003234.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000003234.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000003234.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000003234.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000003234.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
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DR RefSeq; XP_003219560.1; XM_003219512.3.
DR AlphaFoldDB; G1KBS4; -.
DR STRING; 28377.ENSACAP00000003234; -.
DR Ensembl; ENSACAT00000003317.4; ENSACAP00000003234.3; ENSACAG00000003265.4.
DR GeneID; 100564184; -.
DR KEGG; acs:100564184; -.
DR CTD; 115111; -.
DR eggNOG; KOG0236; Eukaryota.
DR GeneTree; ENSGT01100000263544; -.
DR HOGENOM; CLU_003182_9_5_1; -.
DR InParanoid; G1KBS4; -.
DR OrthoDB; 1067648at2759; -.
DR TreeFam; TF313784; -.
DR Proteomes; UP000001646; Chromosome 4.
DR Bgee; ENSACAG00000003265; Expressed in ovary and 3 other cell types or tissues.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0005768; C:endosome; IEA:Ensembl.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:Ensembl.
DR GO; GO:0015106; F:bicarbonate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005254; F:chloride channel activity; IEA:Ensembl.
DR GO; GO:0015108; F:chloride transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0140900; F:chloride:bicarbonate antiporter activity; IEA:Ensembl.
DR GO; GO:0019531; F:oxalate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0001696; P:gastric acid secretion; IEA:Ensembl.
DR GO; GO:0035429; P:gluconate transmembrane transport; IEA:Ensembl.
DR GO; GO:0015705; P:iodide transport; IEA:Ensembl.
DR GO; GO:0015706; P:nitrate transmembrane transport; IEA:Ensembl.
DR GO; GO:0006590; P:thyroid hormone generation; IEA:Ensembl.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814:SF75; ANION EXCHANGE TRANSPORTER; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 65..93
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 203..220
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 226..245
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 257..275
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 308..327
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 348..373
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 379..397
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 444..470
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 492..642
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
SQ SEQUENCE 657 AA; 72579 MW; 492C0C968F7FF009 CRC64;
MTGTKREKKN AIWRKIHALR FEDVKRWCVR RLPVLEWAPN YNWRADLVPD TVSGMMLAVQ
QVTQGLAFAV LSSVHPVFGL YGALFPAVIY AMFGMGRHVA TGTFALTSLI SANAVERLVP
SVRNNFTTNN TSAVLGLSDF DMQRIGVAAA VSLLGGLIQV AMFVLHLGSA TFLLTEPVIS
AMTTGAATHV VTSQVKHLLG MKMPYISGPL GFFYIYAYIF ENIKSIQLEA LLLSVLSIGV
LVLVKELNEK FKNKIKVVLP IDLVWIIASS VASYSTDLKN SYGLDVVGHI PEGIPPPQPP
PMNILPEIVT EAFSVALVGY VASLALARSS AKKFNYSMDD NQELLAHGLS NVIPSFFFCI
PSAAAMGRTI LLYSTGAKTQ VACLISCILV LVVIYAIGPM LCWLPMCVLA SIIVVGLKGM
LMQFRDLKKY WNVDKIDWSI WVSTYVFTIC FAANVGLLYG VVCTILIVVF RFPRATTLSL
KQMKEAECRF KTETDSDSSQ QVKIVSINNP LVFLNAKKFH MDISKLIQKE ITCMYLPEDM
DKFEQNTLLS PVSNGNCHGE SSLQQRTVER QTLIFDCSGL TLFDYTGIAV LTQIYTDSKK
RNIDVLLANC KASLIKALKL NSRLESDNAV FFESVSSAVG AIQFNRNFCK LNEHTEV
//
