ID G1KCB0_ANOCA Unreviewed; 2548 AA.
AC G1KCB0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Neural-cadherin {ECO:0008006|Google:ProtNLM};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000003770.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000003770.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000003770.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000003770.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 28377.ENSACAP00000003770; -.
DR Ensembl; ENSACAT00000003862.3; ENSACAP00000003770.3; ENSACAG00000003855.3.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000164400; -.
DR HOGENOM; CLU_000347_1_0_1; -.
DR InParanoid; G1KCB0; -.
DR TreeFam; TF351842; -.
DR Proteomes; UP000001646; Chromosome 4.
DR Bgee; ENSACAG00000003855; Expressed in embryonic post-anal tail and 2 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 13.
DR CDD; cd00054; EGF_CA; 4.
DR CDD; cd00110; LamG; 2.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 2.60.40.60; Cadherins; 14.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF442; DACHSOUS CADHERIN-RELATED 2; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 12.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF02210; Laminin_G_2; 2.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 13.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00282; LamG; 2.
DR SUPFAM; SSF49313; Cadherin-like; 15.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS00232; CADHERIN_1; 6.
DR PROSITE; PS50268; CADHERIN_2; 14.
DR PROSITE; PS00022; EGF_1; 3.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS50025; LAM_G_DOMAIN; 2.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2352..2372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 75..174
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 175..275
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 285..377
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 378..484
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 496..593
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 594..693
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 694..805
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 806..920
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 921..1022
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1023..1129
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1140..1243
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1244..1351
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1361..1457
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1457..1571
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1821..1860
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1861..2038
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2034..2073
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2076..2253
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2254..2290
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2298..2335
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1850..1859
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2063..2072
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2325..2334
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2548 AA; 281476 MW; AC3140F39C1B9BBF CRC64;
MPALRLRNGD EHQPPESDMT GLNVRGKPLP LPFFQSHSPV LKLPYMLALL SESDWYICRV
VVIAVEEEPI SWGMFPYPYL ARIDPEARAG TLVYQLAAHY SNNENSSTGI SYALIAGGEE
RFDIDTDTGA LLTTGLPLTL NQEYVVTVLA IDEYGSKSPY AFISILAGSR PPQFTNMSYS
VFIPENTPPN ERVADVEAVS FQSQPICYTL LMNPSGLFIL DQETGELSLT HAVDYESEHH
LYHFLVKAME RESLLSSVTE VIVHITDEND CFPEFQQSIY SRENILESIP IGTSLLQVLA
TDCDSGSNSE IIYFLQTADF SITPEGVISS NQQLDFEQSN HMYEFVVIAV DQGHPARTGT
ASVRIRMANV NDESPVFSQS VYETFLSEDA GPGTLVATIL AKDPDGDGVM YLISGGNEEG
NFELDSRKGI LRLRRNPVPK LKGPEYVLNI SAIDDNTSGG PRSLCSFAEV VVGINDINNN
KPIFRECAYY SDNTWVLENQ PPGTYVLRVE AYDADLGQNG EVKYSLMHRD GSLPGFSIDP
DSGVITTTRS FDREKQREYM LSVIATDQAQ EPLIGMCQIT IYIADENDND PKFENSRYQY
FLREDTPVGT SFLCATAHDD DQGANAAITY SMVQQEPEYF KINPSTGWVY VNHVISQTFQ
INRYITATDG GNRSSTVELT VTITDVLNQS PQWDESSYSI TIPESTARDT KIVTVKATSP
LGDPRVTYHL EEGQVPETNM PVRFYLKPNR ADGSASLLVA EPLDFETTKL FTLSIKAQNV
ATIPLASFTT VYVNITDVND NVPFFTSSTY EVSVPEGAGI GTSVMQVLAT DADSGLNGEV
HYSILKDSSG DYQYFTIDST SGVISTLASF DREKRASYLI EVQSQDSSES ARPGIYGQPN
TDTAYVRIFI SDVNDNCPAF PHLVYETDVD EDQDVGYAVL TATATDKDEG SNAKLRYQIT
SGNEQGDFYV EPEKGTILIA QHLDYEQERH YKLQLVTSDG KWENHTLVVI NVININDEAP
VFSQDEYHGS VLEELADLPV LVLQVSATDP DQETKQGGFC YSLHGQGAQS EFSINELTGE
ITANERLDRE KRSMWRFLVL ATDEDGEGLT GFADVIIEVL DVNDNAPLFL CASDGCFMGQ
IPEDSPADST VMEMLAIDLD DPAAGKNAVL TYNIIQNVKN EINLNLFSVN PVTGTIYTVL
STLDREKRDK YLVVVEAKDG GGLTGTGTAT ILVTDINDHA PAFTQKIYTA FVSEGASVNT
LVAEVSATDE DEGENAVVTF SILDGDDDHK FYIETDKANK CGVIRLRKEI DFEKPHERVF
NLTVKAEDLD FFSIAHCVIY VEDYNDHAPL FYPQFYEVAG LAEDVSLGTK VVQVIGIDLD
SGLNGRFSYR LLNKSDPSGR FSVANDGWVI VAGELDYETV AQYQLVVIAT DMGQPALSSS
ATVLVALQDV NDNGPEFDAL YNPVVWENTP SPQVVQMNDT STLLYAKDRD SPANGAPFSF
HLLSDFGSVT YFNLQDFSNG SAMLIALHTF DREVHKVFHL RILIADSGNP PMSSTNTLTV
NIGDRNDHPH AAGYMECLIY SYNGILPTTV LGKIHAPDND DWDHKTYHFE EKAPRHFILN
DNSGLLSIKE GTPAGIYDLR VKVTDGIWPD VVSTVKVVVK EIKEEAAHNA GSVRIRDITA
EDFIYQSSES ESKYNQMKML FSEIISAQLE NVHIFSVLNS PGETQGVDIW FAIHGSPYYK
AEKLNGNIAV SKARLETVLN INITQIGIDE CVTANCSHST GCISKNEFSP LPTITTSGNV
LLASVTVFSN AQCTCEARER KHHSCSSYRI NPCFNGGTCT DTDLGYSCKC PNTFHGPECQ
QTQHTFRGHG YAWFPPIKPC FQSRISLDFI TEVADGLLLY NGPVARVKPG EPSFAGLKWR
HTKLSSHKCR KVQLILDHCA NVSFTNNDDA QEDVSKVDHS VCKVSSETPG SDRNLDVHQP
LQLGGVKKAQ PYHTSQKHFK GFVGCIRNVI IDSQVYNLEQ PAESLNSAPG CSLTDGLCQK
SGIPSCGVHG KCIGDWGSFN CDCFTGYMGA RCDKALLEWN FGKDSWILYD LKNVFSAYNT
HVRLSVRTRT SSSTLLSLAS SVGNGFIRLE IIGGYFGVSF NFGGKDHVLQ LSTVRIDNGQ
WIELTLERYH NEFSLLINDG GGDHEVSAIL GSGGQFKINL ARIVLGNRLV NHSESDFQGC
MRDVRLNGQP LLVNGESTEY SFIVEQEGIT IGCHSNSCSN QPCYNPFHCV DLWRKYECRC
PAGKVEVTDN LTGLKQCTSS PCGHWNCRNG GTCVAQSRDK YVCQCPEGYK GKWCEVSPVK
AGRPVGLSSG SILAISMCLL VFLGLLVSYT VWSQWGRSRF RKGGIYHIPE EHESWDDVRE
NVFNYNEEGG GEHDLSAYNL DTLKKPVQII PPFSSGTAAP VLRSYSGSQI NPHGNPACLR
ETPSLDTSLP DFKHCMSQRI QNADSNQKHL PTDSMHFYCL EGQGSPAGSL SSLETSSVEQ
DLNYENLNEW GSEFVKLKQL HELRTEQL
//
