ID G1KDA9_ANOCA Unreviewed; 555 AA.
AC G1KDA9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Neuralized E3 ubiquitin protein ligase 1 {ECO:0000313|Ensembl:ENSACAP00000004797.3};
GN Name=NEURL1 {ECO:0000313|Ensembl:ENSACAP00000004797.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000004797.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000004797.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000004797.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000004797.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_008104798.1; XM_008106591.1.
DR AlphaFoldDB; G1KDA9; -.
DR STRING; 28377.ENSACAP00000004797; -.
DR Ensembl; ENSACAT00000004905.4; ENSACAP00000004797.3; ENSACAG00000004920.4.
DR GeneID; 100559648; -.
DR CTD; 9148; -.
DR eggNOG; KOG4172; Eukaryota.
DR eggNOG; KOG4625; Eukaryota.
DR GeneTree; ENSGT00940000156696; -.
DR HOGENOM; CLU_013230_1_0_1; -.
DR InParanoid; G1KDA9; -.
DR OrthoDB; 5471056at2759; -.
DR TreeFam; TF314368; -.
DR Proteomes; UP000001646; Chromosome 3.
DR Bgee; ENSACAG00000004920; Expressed in testis and 4 other cell types or tissues.
DR GO; GO:0097440; C:apical dendrite; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0043197; C:dendritic spine; IEA:Ensembl.
DR GO; GO:0043204; C:perikaryon; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0014069; C:postsynaptic density; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045183; F:translation factor activity, non-nucleic acid binding; IEA:Ensembl.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0045746; P:negative regulation of Notch signaling pathway; IBA:GO_Central.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0060999; P:positive regulation of dendritic spine development; IEA:Ensembl.
DR GO; GO:0051491; P:positive regulation of filopodium assembly; IEA:Ensembl.
DR GO; GO:0048170; P:positive regulation of long-term neuronal synaptic plasticity; IEA:Ensembl.
DR GO; GO:0090129; P:positive regulation of synapse maturation; IEA:Ensembl.
DR GO; GO:0006513; P:protein monoubiquitination; IEA:Ensembl.
DR GO; GO:0007288; P:sperm axoneme assembly; IEA:Ensembl.
DR Gene3D; 2.60.120.920; -; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR037962; Neuralized.
DR InterPro; IPR006573; NHR_dom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12429:SF13; E3 UBIQUITIN-PROTEIN LIGASE NEURL1; 1.
DR PANTHER; PTHR12429; NEURALIZED; 1.
DR Pfam; PF07177; Neuralized; 2.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00588; NEUZ; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51065; NHR; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 45..201
FT /note="NHR"
FT /evidence="ECO:0000259|PROSITE:PS51065"
FT DOMAIN 274..428
FT /note="NHR"
FT /evidence="ECO:0000259|PROSITE:PS51065"
FT DOMAIN 502..542
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 555 AA; 61258 MW; 7A197E28F414B378 CRC64;
MGGQLTRSTL YDSIGGPFPA SSHRCHHKQK HCLPIPQCGA LSISPLLFHP HTKGSQIIMD
TTQKAVKRQA SFCNAITFSN RPIVIYEQVR LKITKKQCCW SGALRLGFTS KDPSRINPET
LPKYACPDLV SQSGFWAKAL PEEFANEGNI IAFWVDKKGR VFYRVNDSAA MLFFSGVRTT
EPLWALIDVY GLTRGVQLLD SELIPPDCLR PRSFTAIRRP SLRRETEDTR LSVSLCDLNL
QEENFHVMAA MCPIPQNSLN SQHSHLLPSQ LESDLRFHQL RGAHIKILDD QTVARLDHAR
EERTLVFTSR PLRINETIFV KINKSNTSRT GTLSYGVTTC DPSTLRPSDL PYNPESLVDR
KEFWAVCRVL VPLQSGDILG FMVNSEGELH LSHNGANTGM QVCVDCSQPL WMFFGLHGAV
MQIRVLGSTL MAERLGPSAP SSPTSSPNSP SVLCSGVSDP VLSTCGSGPL GSSLSGTAPN
SPVSMPESPL SPSISGSWND ECTICYENMV DTVIYSCGHM CLCYTCGLKL KKMANACCPI
CRRAIKDIIK TYRST
//
