ID   G1KH05_ANOCA            Unreviewed;      1317 AA.
AC   G1KH05;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 3.
DT   27-MAR-2024, entry version 66.
DE   SubName: Full=VPS8 subunit of CORVET complex {ECO:0000313|Ensembl:ENSACAP00000007601.4};
GN   Name=VPS8 {ECO:0000313|Ensembl:ENSACAP00000007601.4};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000007601.4, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000007601.4, ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000007601.4,
RC   ECO:0000313|Proteomes:UP000001646};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000007601.4}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the VPS8 family.
CC       {ECO:0000256|ARBA:ARBA00009422}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   STRING; 28377.ENSACAP00000007601; -.
DR   Ensembl; ENSACAT00000007762.4; ENSACAP00000007601.4; ENSACAG00000007715.4.
DR   eggNOG; KOG2079; Eukaryota.
DR   GeneTree; ENSGT00390000010672; -.
DR   HOGENOM; CLU_000917_1_2_1; -.
DR   TreeFam; TF314244; -.
DR   Proteomes; UP000001646; Chromosome 3.
DR   Bgee; ENSACAG00000007715; Expressed in dewlap and 13 other cell types or tissues.
DR   GO; GO:0033263; C:CORVET complex; IBA:GO_Central.
DR   GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR   GO; GO:0030897; C:HOPS complex; IBA:GO_Central.
DR   GO; GO:0005770; C:late endosome; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0034058; P:endosomal vesicle fusion; IBA:GO_Central.
DR   GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR   CDD; cd16687; RING-H2_Vps8; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR045111; Vps41/Vps8.
DR   InterPro; IPR025941; Vps8_central_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR12616; VACUOLAR PROTEIN SORTING VPS41; 1.
DR   PANTHER; PTHR12616:SF8; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG; 1.
DR   Pfam; PF12816; Vps8; 1.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   REPEAT          165..206
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   DOMAIN          1153..1205
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
SQ   SEQUENCE   1317 AA;  149072 MW;  75F84804BBE438F6 CRC64;
     TSYEPISASS RSKAHLKIHF LRLDRKIDDK EFDIPQVDTP PTLESILNET DDEEEPFVLE
     DPSLLNIDNI DTHSYDTSSV ASSDSGDRTH LKRKKKLRDS FSIHGSVIRL SLLKGISAQI
     VSAAVSTSFP LISTSSLIAV GTSHGLALIF DPNQALRLCL GSTAVGAQYG AISALSINND
     CSRLLCGFAK GQITMWDLAS GKLLRSITDA HPPGTAILHI KFTDDPTLAI CNDSGGSVFE
     LSFKRVMGVR TCESRCLFSG SKGEVCCIEP LHAKAELRDH PITQYSLLAM ASLTKILVIG
     LKPSLKVWMT FPYGRMDPSS VPLLAWHFVA VQTAVNPVLA FCRGDVVHFL LVKRDDSGAI
     HVTKQKQLHL HYDLINFTWI NSRTVVLLDS VEKLHVIDRQ TQEELETVEI SEVQLVYNSS
     HFKSLATGGN VSQALALVGE KACYQSISNC GGQIFYVGTK SVHVMTLRSW RERIDHLLKQ
     ECLNEALALA WSFHEGKAKA VVGLSGEEQK RKAVVADRMV EILIHYADRI MKKCPEQGKI
     QVMEQYFQDM VPVIVDYCLL LQRMDLLFSQ MYDKMAENSV AKGVFLECLE PYIISDKLVG
     MTAQIMKDLL LHFQDKNLMA NMEACIVHMD VTSLDIQQVV LMCWENHLYD AMIYVYNSGM
     NDFITPMEVR KCEAIDEQVI MGNKLLVYIS CCLAGRAYPL GNISENLVPL VKNQVFEFLI
     RLHSAEAPVE EEVYPYVRTL LHFDTREFLN VLALTFEDFK NDKQAVEYQQ RIVDILLKVM
     VENSDFTPSQ VGCLFTFLAR QLAKPNNTLF VNRTLFDQVL EFLCSPDDDS RHSERQQVLL
     ELLQAGGIVQ FEESRLIQMA EKAEFYQICE FMYEREHRYD KIIDCYLHDP LRKDQYLLFQ
     FLKSLLDPRE GVNQDLLQLS PSVTEQFIEL LCQYDPEQVL ETLKFLESYR LEETIQIVQK
     KQLYEASSYL LEKKEDIHSA FLVMLEFLQR KLSILTSEDE SSVEVPSLKA IEDTLAKTIA
     LCQRNSHKLN QQQREALWFP LLEAMMSPKR SSSSTVLGHY SEFLKNLTMQ VLNNMAAFIS
     LPLILQRILQ DPVYGRGKLG EIQGLVLGML DSFNYEQTLL ETTTNLLNHD LHWSLRNLKA
     SVTRGLNPKQ DYCCICLQQY KRRQETSDQI IVFSCGHLYH SLCLMSKECG IESKGQIRWT
     CFKCSASHKG GKLSEASSEL KRRTPVSLSQ VRLKLADPPF GGSESLLDPQ QAQAFDQLCR
     LYRGTSRLAL LTELSRDRGG EKHGLLHVSQ GDSALNSVFQ NETFQLHLTP PPPLLDD
//