ID G1KJT5_ANOCA Unreviewed; 710 AA.
AC G1KJT5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Cyclic nucleotide gated channel subunit beta 3 {ECO:0000313|Ensembl:ENSACAP00000009986.3};
GN Name=CNGB3 {ECO:0000313|Ensembl:ENSACAP00000009986.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000009986.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000009986.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000009986.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000009986.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; G1KJT5; -.
DR STRING; 28377.ENSACAP00000009986; -.
DR Ensembl; ENSACAT00000010192.3; ENSACAP00000009986.3; ENSACAG00000010084.3.
DR eggNOG; KOG0499; Eukaryota.
DR GeneTree; ENSGT00940000154824; -.
DR HOGENOM; CLU_005746_11_1_1; -.
DR InParanoid; G1KJT5; -.
DR TreeFam; TF318250; -.
DR Proteomes; UP000001646; Chromosome 4.
DR Bgee; ENSACAG00000010084; Expressed in forelimb bud and 2 other cell types or tissues.
DR GO; GO:0017071; C:intracellular cyclic nucleotide activated cation channel complex; IBA:GO_Central.
DR GO; GO:0001750; C:photoreceptor outer segment; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030553; F:cGMP binding; IBA:GO_Central.
DR GO; GO:0005222; F:intracellular cAMP-activated cation channel activity; IBA:GO_Central.
DR GO; GO:0005223; F:intracellular cGMP-activated cation channel activity; IBA:GO_Central.
DR GO; GO:0044877; F:protein-containing complex binding; IBA:GO_Central.
DR GO; GO:0098655; P:monoatomic cation transmembrane transport; IBA:GO_Central.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45638:SF8; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL BETA-3; 1.
DR PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS00889; CNMP_BINDING_2; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 449..553
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 624..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..674
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 710 AA; 80368 MW; A653CD03D7A36303 CRC64;
QRNQCKLSCK TQFSPIYFEF IKITVICYVS KLYQYYIVFL TSQLFFFPIP STNSAENKRP
GTPINEYVQE QLKEIVKKMK ERTAEYREKL TDPVMSSPEP SPTASKSTEI VSCTILEPPS
ILPPMKAYMK KMKLPESIDA YTDRRYIGWL FVVTMTYNWN CWFIPLRLAF PVHTASNMIH
WIVVDLLCDL CYICDVLVFQ PRVQFVRGGD IIVNRAELKK YYRNSLKFRL DVFSVIPFDV
LYAIFGFHAI FRANRHLTFF EFNDRLEGIM DKAYIYRVIR TTGYLLFILH LNACVYYCAS
VYEGLGSTKW VYDGKGNMYL RSYYWAVRTL ITIGGLPEPV TTFEIIFQLL NFFSGVFVFS
SLIGQMRDVI GAATAGQNYY RACMDNTVSY MNVNTIPRIV QNRVRTWYEY TWDSQGMLDE
SELLEQMPGK MHLAIAIDVN FTIVSKVDLF KGCDVQMICD MLLRLKSIVY LPGDFVCKKG
EIGREMYIIK QGEVQVLGGP DGTKVLVTLR AGAVFGEISL LAASGGNRRT ANVVAHGFAN
LFILDKKTLN EILVHYPDSE MLLRKKGKAL MKKAGKPPPG PAPTAKGFSL LTQKIEPPKM
FQALLGGKGG GMAAILQLKR EQVRNGKDKQ PPVPQDQAPQ TQPKPVAQKE EPIASCQPPP
PPPPPRPPSP PKPSLLRGIT DQSLIITMGP STVPGEGEIL TVEVKEKKQT
//
