ID G1KJZ1_ANOCA Unreviewed; 499 AA.
AC G1KJZ1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=RasGEF domain family member 1B {ECO:0000313|Ensembl:ENSACAP00000010126.4};
GN Name=RASGEF1B {ECO:0000313|Ensembl:ENSACAP00000010126.4};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000010126.4, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000010126.4, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000010126.4,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000010126.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G1KJZ1; -.
DR STRING; 28377.ENSACAP00000010126; -.
DR Ensembl; ENSACAT00000010334.4; ENSACAP00000010126.4; ENSACAG00000010279.4.
DR eggNOG; KOG3541; Eukaryota.
DR GeneTree; ENSGT00940000155816; -.
DR HOGENOM; CLU_022907_2_0_1; -.
DR OrthoDB; 7992at2759; -.
DR TreeFam; TF313379; -.
DR Proteomes; UP000001646; Chromosome 5.
DR Bgee; ENSACAG00000010279; Expressed in ovary and 12 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF197; RAS-GEF DOMAIN-CONTAINING FAMILY MEMBER 1B; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 34..164
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 204..452
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 499 AA; 58094 MW; B414E0B7596767A4 CRC64;
MPQTPPFAAM FDSSGYNRNL YQSREDSCEG LCYHDNNLLS GSLEALIQHL VPTIDYYPDR
TYIFTFLLSS RLFVHPYELM AKVCRLCTEQ QRLDEPAGDK SRLRKIAPKI LQLLTEWTET
FPYDFRDERM MRNLKDLAHR IASGDEMYRK NVQQIIQSLI RKLASLSQYE EVLAKINASS
TDRLTVLKTK PQAIQRDIIT ICSDPYMLAQ QLTHIELERL NYIGPQEFVQ AFVQKDPLDN
DKSCYGDRKK TRNLEAYVEW FNRLSYLVAT EICMPVKKKH RARMIEYFID VARECFNIGN
FNSLMAIISG MNMSPVSRLK KTWSKVKTAK FDILEHQMDP SSNFYNYRTA LRGAAQRSLT
AHSNREKIVI PFFSLLIKDI YFLNEGCANR LPNGHVNFEK FWELAKQVSE FMTWKQVECP
FERDRKILQY LLTVPIFSED ALYLASYESE GPENHIEKDR WKTLRSVSEG AAIHKSTDCK
LALPLDTFKA KCLAACLNR
//
