ID G1KN58_ANOCA Unreviewed; 413 AA.
AC G1KN58;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=TGF-beta family profile domain-containing protein {ECO:0000259|PROSITE:PS51362};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000012803.4, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000012803.4, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000012803.4,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000012803.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR AlphaFoldDB; G1KN58; -.
DR STRING; 28377.ENSACAP00000012803; -.
DR Ensembl; ENSACAT00000013059.4; ENSACAP00000012803.4; ENSACAG00000013046.4.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00940000159784; -.
DR HOGENOM; CLU_055377_1_0_1; -.
DR TreeFam; TF351788; -.
DR Proteomes; UP000001646; Chromosome 2.
DR Bgee; ENSACAG00000013046; Expressed in ovary and 2 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF19; GROWTH_DIFFERENTIATION FACTOR 9; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 300..413
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 278..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..309
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 413 AA; 47256 MW; 567DCE3C03EA52DD CRC64;
MENNSKPLGD EDDIQPLLMS EMEASKAPPE LLLPPDVENG RGPLTPLFKV LSGHSHQALE
DGTPRPLPDA RALRYMKRLY KMFATKEGIP KTNKNHIYNT VRLFTPHAEC KHLPKGQVEG
DLHSVDLLFN LDCVTSMEHL LKSVLLYSID KSVSKSLAIM CTGNLIVKEH DVSSQVCPNV
PHAMAFSLYF ELRRKWVEID VTTFLRPLIA SNKRKIHMAM NFTCLKNDPS PGFHQDFFNM
VLVSPSLLLY LNDTSEQAYH GRNSLKQKSN NSLGLKLKIP STDPNEKPEK DFQQSKRALR
QRRDEGGAKK NTPVPIYDLS QYYEQFLFHQ NECELHNFWL RFSQLKWDRW IIAPHKYNPR
YCKGECPRVV GHRYGSAVHT MVQNIIYEKL DSSVPRPSCV PAEYSPLSVL KGT
//
