ID G1KNM0_ANOCA Unreviewed; 539 AA.
AC G1KNM0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Potassium two pore domain channel subfamily K member 10 {ECO:0000313|Ensembl:ENSACAP00000013114.3};
GN Name=KCNK10 {ECO:0000313|Ensembl:ENSACAP00000013114.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000013114.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000013114.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000013114.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000013114.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the two pore domain potassium channel (TC
CC 1.A.1.8) family. {ECO:0000256|ARBA:ARBA00006666,
CC ECO:0000256|RuleBase:RU003857}.
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DR RefSeq; XP_008114644.1; XM_008116437.2.
DR AlphaFoldDB; G1KNM0; -.
DR STRING; 28377.ENSACAP00000013114; -.
DR Ensembl; ENSACAT00000013374.4; ENSACAP00000013114.3; ENSACAG00000013306.4.
DR GeneID; 100564560; -.
DR KEGG; acs:100564560; -.
DR CTD; 54207; -.
DR eggNOG; KOG1418; Eukaryota.
DR GeneTree; ENSGT00940000156147; -.
DR HOGENOM; CLU_022504_10_0_1; -.
DR InParanoid; G1KNM0; -.
DR OrthoDB; 600333at2759; -.
DR TreeFam; TF313947; -.
DR Proteomes; UP000001646; Chromosome 1.
DR Bgee; ENSACAG00000013306; Expressed in adrenal gland and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015271; F:outward rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:0022841; F:potassium ion leak channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0030322; P:stabilization of membrane potential; IBA:GO_Central.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR003280; 2pore_dom_K_chnl.
DR InterPro; IPR003976; 2pore_dom_K_chnl_TREK.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR11003:SF32; POTASSIUM CHANNEL SUBFAMILY K MEMBER 10; 1.
DR PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR Pfam; PF07885; Ion_trans_2; 2.
DR PRINTS; PR01333; 2POREKCHANEL.
DR PRINTS; PR01499; TREKCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU003857};
KW Ion transport {ECO:0000256|RuleBase:RU003857};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003857};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003857}.
FT TRANSMEM 73..94
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 268..289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 301..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 149..206
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT DOMAIN 246..324
FT /note="Potassium channel"
FT /evidence="ECO:0000259|Pfam:PF07885"
FT REGION 516..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..539
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 539 AA; 60263 MW; E76B2FB190707492 CRC64;
MKFPIETPRK QVNWDPQVTV PAAVPPACEP ETNKTNVHHP GPRLSLSSPR TSVIVSMEAP
SQGLQTVMKW KTVVAIFFVV VAYLVTGGLV FRALEQPEEN SQKTRIANDK AEFLQENNCV
SQQELEALIK RVINATNAGV NPVGDSSNSS SHWDLGSAFF FAGTVITTIG YGNIAPSTEG
GKIFCILYAI FGIPLFGFLL AGIGDQLGTI FGKSIARVEK VFRKKQVSQT KIRVISTILF
ILAGCVLFVT IPAVIFKYME EWSVLDSFYF VVVTLTTVGF GDFVAGGNAE IPYREWYKPL
VWFWILVGLA YFAAVLSMIG DWLRVISKKT KEEVGEIKAH AAEWKANVTA EFRETRRRLS
VEIHDKLQRA ATIRSMERRR LGLDQRAHSL DMLSPEKRCV FAALDSGHFK ASSQESINSK
PNNLRLKGSE QLTKHGQGAS EDNIINKFGS SSKLTKRKNK DLKKCIPEDV RKIYETFRNY
SLDEEKKEED SEKGCHSDHS STAVLTDCIE QHLGLENGII PSETKEREHE NKSLLEDRN
//
