ID G1KP15_ANOCA Unreviewed; 432 AA.
AC G1KP15;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Cell adhesion molecule 2 {ECO:0000313|Ensembl:ENSACAP00000013385.4};
GN Name=CADM2 {ECO:0000313|Ensembl:ENSACAP00000013385.4};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000013385.4, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000013385.4, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000013385.4,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000013385.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nectin family.
CC {ECO:0000256|ARBA:ARBA00007810}.
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DR AlphaFoldDB; G1KP15; -.
DR STRING; 28377.ENSACAP00000013385; -.
DR Ensembl; ENSACAT00000013657.4; ENSACAP00000013385.4; ENSACAG00000013590.4.
DR eggNOG; ENOG502QV9X; Eukaryota.
DR GeneTree; ENSGT00940000155947; -.
DR HOGENOM; CLU_047574_2_1_1; -.
DR InParanoid; G1KP15; -.
DR Proteomes; UP000001646; Chromosome 3.
DR Bgee; ENSACAG00000013590; Expressed in testis and 9 other cell types or tissues.
DR GO; GO:0032809; C:neuronal cell body membrane; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IBA:GO_Central.
DR CDD; cd05884; IgI_2_Necl-3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR003585; Neurexin-like.
DR PANTHER; PTHR45889:SF1; CELL ADHESION MOLECULE 2; 1.
DR PANTHER; PTHR45889; IG-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00294; 4.1m; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..112
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 125..215
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 225..310
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 432 AA; 47308 MW; 62D3B0D5818F5495 CRC64;
MSTTLWSGTK MTGNIVKSGS QGQFPLTQNV TVIEGETATL TCRVDQNDNT SLQWSNPAQQ
TLYFDDKKAL RDNRIELLRA SWHELTIRVT DVSLSDEGQY TCSLFTMPVK TSKAFLTVLG
VPESPQITGF VSPVMEGDRM ELTCKTSGSK PAADIRWFKN DKEVKDVKYL KEEDANRKTF
TVSSTMNFKA DRSDDGAVVS CRVDHESLHS SPQIAMQVLE IHYIPSVKII PSTLWPEEGQ
SITLICESKG KPLPDPVLWT KDGGELPDPE RMIVNGRELN IHMLNKTDNG TYRCEAENSI
GLNSAEYVLI IRDVSNILLP TTVIPSLTTA TVTTTVALTS TVPSATAIDT RDPNGYPGPT
GTDHAVIGGI VAVVVFVTLC SIILLGRYLA RHKGTYLTNE AKGAEDAPDA DTAIINAEGS
QVNAEEKKEY FI
//
