ID G1KUK5_ANOCA Unreviewed; 1053 AA.
AC G1KUK5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Leucine rich repeats and immunoglobulin like domains 2 {ECO:0000313|Ensembl:ENSACAP00000017670.3};
GN Name=LRIG2 {ECO:0000313|Ensembl:ENSACAP00000017670.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000017670.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000017670.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000017670.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000017670.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_003220507.2; XM_003220459.3.
DR AlphaFoldDB; G1KUK5; -.
DR STRING; 28377.ENSACAP00000017670; -.
DR Ensembl; ENSACAT00000018018.4; ENSACAP00000017670.3; ENSACAG00000017947.4.
DR GeneID; 100560844; -.
DR KEGG; acs:100560844; -.
DR CTD; 9860; -.
DR eggNOG; KOG4194; Eukaryota.
DR GeneTree; ENSGT00940000158791; -.
DR HOGENOM; CLU_000288_18_24_1; -.
DR InParanoid; G1KUK5; -.
DR OrthoDB; 5405965at2759; -.
DR TreeFam; TF325380; -.
DR Proteomes; UP000001646; Chromosome 4.
DR Bgee; ENSACAG00000017947; Expressed in hemipenis and 13 other cell types or tissues.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0030426; C:growth cone; IEA:Ensembl.
DR GO; GO:0097708; C:intracellular vesicle; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
DR GO; GO:0060384; P:innervation; IEA:Ensembl.
DR GO; GO:0006509; P:membrane protein ectodomain proteolysis; IEA:Ensembl.
DR GO; GO:0048681; P:negative regulation of axon regeneration; IEA:Ensembl.
DR GO; GO:0051045; P:negative regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR GO; GO:2000010; P:positive regulation of protein localization to cell surface; IEA:Ensembl.
DR GO; GO:0034394; P:protein localization to cell surface; IEA:Ensembl.
DR GO; GO:2001222; P:regulation of neuron migration; IEA:Ensembl.
DR GO; GO:0010640; P:regulation of platelet-derived growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR CDD; cd05763; IgI_LRIG1-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45842:SF19; LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 2; 1.
DR PANTHER; PTHR45842; SYNAPTIC ADHESION-LIKE MOLECULE SALM; 1.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01463; LRRCT; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00365; LRR_SD22; 7.
DR SMART; SM00369; LRR_TYP; 11.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS51450; LRR; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1053
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003413126"
FT TRANSMEM 792..818
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 487..586
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 591..680
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 685..759
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 848..877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 848..874
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1053 AA; 117816 MW; 7087CE0237E63B32 CRC64;
MRWRRGFPPR PIGLLFVLLL QRAAGEACAP AGPCSCRRGV LDCSRLRATG RSVEPGLLLP
LPPDTTALDL SHNHLSSSNW SIDSSGQKLQ EVKMNYNELT DIPCFGELTS NITLLSLVHN
TIPEIVPEQL QLFVSLENLD LSSNLISEIK ISSFPRMQLK YLNLSNNRIT TLEAGCFDNL
SSSLIVVKLN KNRISVIPPK TFRLPHVQYL ELKRNRIKII DSLTFQGLDS LKSLKMQRNG
ISRLMDGAFF GLDNMEELEL EHNNLTEVNK GWLYGLRTLQ QLYVSQNAIN KIGPDAWEFC
QRLSELDLSY NQLTRLDEFA FVGLNLLERL NLSDNRISHI ADGVFKGLSN LQTLDLRNNE
ISWAIEDSNE AFVGLERLNK LILQGNQIKS ITKRAFFGLQ VLEYLDLNNN AIMSIQENAF
SQPLKELVLN TSSLLCDCQL KWLLQWLTQS NLQDTVNVIC AHPERLAGQS ILTVNPEDFV
CDDFPKPQIR THPETAIALR GTNVTLTCKA VSSSDLPMST TWRKDSEILY DADIETFVRY
QQQDGEVLEY TSILHVFNVN FTDEGKYQCI ISNHFGSNYS NKAKLTVNEL PSFIKTPMDL
TIRTRAMAKL ECAAEGHPPP QISWQKDGGT DFPAARERRM HVMPEDDVFF IANVKIEDMG
IYSCMAQNVA GGISANATLT VLETPSFVRP LEDRTVAQGE TAVLQCIASG SPAPRLNWTK
DDGPLTVTER HFFAAANQLL IIVDAGLEDA GKYTCVMSNT LGTVRGHIYL YVISSPNCDS
SQSGIGIEED GWTTVGIVII VVVCCVVGTS LVWVIVIYHM RRKSEDYSIT NTEEVNLPAD
IPSYLSSQGT LSEPQEGYSN SEAGSNQQLM PPSSGYVHKG TDGGTAQLVI CSDCYDNANI
YSRTREYCPY AYVTEDDPLD QTLSNLMVQM SKEPYPVCPQ HEATTLDGLP GDRDMSVFLN
NQDRLHEKKP CPQPCNTDPF RLSLWGVNKD LGLLHPCFSP QPKTHDVPHV LLSEGIAETG
QEQVISPRSH HKLHEHNFDF DRTQNLQEHH EAT
//
