ID G1L3K9_AILME Unreviewed; 1084 AA.
AC G1L3K9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN Name=UBE3C {ECO:0000313|Ensembl:ENSAMEP00000001469.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000001469.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000001469.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000001469.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G1L3K9; -.
DR STRING; 9646.ENSAMEP00000001469; -.
DR Ensembl; ENSAMET00000001526.2; ENSAMEP00000001469.2; ENSAMEG00000001353.2.
DR eggNOG; KOG0942; Eukaryota.
DR GeneTree; ENSGT00940000156321; -.
DR HOGENOM; CLU_002173_2_1_1; -.
DR InParanoid; G1L3K9; -.
DR TreeFam; TF106144; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0035519; P:protein K29-linked ubiquitination; IEA:Ensembl.
DR GO; GO:0070936; P:protein K48-linked ubiquitination; IEA:Ensembl.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00612; IQ; 1.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00015; IQ; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS50096; IQ; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 745..1084
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1052
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1084 AA; 123670 MW; 5ACA35D5D8BB53BE CRC64;
MFSFEGDFKT RPKVSLGGAS RKEEKASLLH RTQEERRKRE EERRRLKNAI IIQSFIRGYR
DRKQQHAIQR SAFDRCAGAS QSGGTFSIAS GPNLTLLVRQ LLFFYKQNED SKRLIWMYQN
LIKHSSLFVQ QLDGSERLTC LFQIKRLMSL CCRLLQNCND DSLNVALPMR MLEVFSSENT
YLPVLRDASY VVSIIEQILH YMIQNGYYRS LYLLINSKLP SSIEYSDLSR VPIANILLEN
VVKPLHFTYN SCPEGARQQV FSAFTEELLA APFTDQIFHF IIPALADARA VFPYEPFLSA
LLLLESRCSK TSSGAPWLFF FVLTVGEHYL GTLSEEGLLV YLRVLQTFLS QLPVSPAGTS
CQDSASDSED EGEEADKQPS APEDGRLSVP YITEECLKKL DTKQQTNALL NLVWRDSASE
EAFTLMASIG HTLMVQHRMV VPKVRLLYSL AFNARFLRHL WFLISSMTTR MTTGSMVPLL
QMISRGSPMS LEDSSRIIPL FYLFSSLFSH SLISIHDNEF FGDPIEVVGQ RQSSMMPFTL
EELIMLSRCL RDACLGIIRL AYPETKPEVR EEYITAFQSI GVTTNSEMQQ CIQMEQKRWI
QLFKVITNLV KMLKSRDTRR NFCPPNHWLS EQEDIKADKV TQLYVPASRH VWRFRRMGRI
GPLQSSLDVG LESPPLSVSE ERQLAILTEL PFVVPFEERV KIFQRLIYAD KQEVQGDGPF
LDGINVTIRR NYIYEDAYDK LSPENEPDLK KRIRVHLLNA HGLDEAGIDG GGIFREFLNE
LLKSGFNPNQ GFFKTTNEGL LYPSPAAQML VGGSFARHYF FLGRMLGKAL YENMLVELPF
AGFFLSKLLG TSADVDIHHL ASLDPEVYKN LLFLKSYEGD VEELGLNFTV VNNDLGEAQV
VELKFGGKDI PVTSANRIAY IHLVADYRLN RQIRQHCLAF RQGLANVLDL EWLRMFDQQE
IQVLISGAQV PISLEDLKSF TNYSGGYSAD HPVIRVFWRV VEGFTDEEKR KLLKFVTSCS
RPPLLGFKEL YPAFCIHNGG SDLERLPTAS TCMNLLKLPE FYDETLLRSK LLYAIECAAG
FELS
//
