ID G1L4D3_AILME Unreviewed; 857 AA.
AC G1L4D3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Myosin VIIA and Rab interacting protein {ECO:0000313|Ensembl:ENSAMEP00000001743.2};
GN Name=MYRIP {ECO:0000313|Ensembl:ENSAMEP00000001743.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000001743.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000001743.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000001743.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_002926655.1; XM_002926609.3.
DR RefSeq; XP_019662938.1; XM_019807379.1.
DR AlphaFoldDB; G1L4D3; -.
DR STRING; 9646.ENSAMEP00000001743; -.
DR Ensembl; ENSAMET00000001816.2; ENSAMEP00000001743.2; ENSAMEG00000001633.2.
DR GeneID; 100473210; -.
DR KEGG; aml:100473210; -.
DR CTD; 25924; -.
DR eggNOG; ENOG502QPUS; Eukaryota.
DR GeneTree; ENSGT00950000183138; -.
DR HOGENOM; CLU_008568_0_0_1; -.
DR TreeFam; TF331599; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR041282; FYVE_2.
DR InterPro; IPR006788; Myrip/Melanophilin.
DR InterPro; IPR010911; Rab_BD.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR14555; MYELIN-ASSOCIATED OLIGODENDROCYTIC BASIC PROTEIN MOBP -RELATED; 1.
DR PANTHER; PTHR14555:SF6; RAB EFFECTOR MYRIP; 1.
DR Pfam; PF02318; FYVE_2; 1.
DR Pfam; PF04698; Rab_eff_C; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50916; RABBD; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 4..124
FT /note="RabBD"
FT /evidence="ECO:0000259|PROSITE:PS50916"
FT REGION 250..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 781..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 468..487
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..534
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..578
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..619
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 857 AA; 95401 MW; C9FACC74DFFD5E0A CRC64;
MGRKLDLSGL TDDETEHVLQ VVQRDFNLRK KEEERLSEMK QRLAEEGSKC SILSKHQKFV
EHCCMRCCSP FTFLVNTKRR CADCKFNVCK SCCSYQKHEK VWICYVCQQA RLLRTQSLEW
FYSNVKSRFK RFGSAKVLKN LYRKHRLESG ACFDILGGNF FEANLENEGS ISGSDSTFYR
QSEGHSMMDT LAVALRVAEE AIEEAISKAE AYGDSLDKQN EASYLRDHKE ELTEELATTI
LQKIIRKQKS KGEKQMEEEP EWSQPQSCRA EAADQGTTAP PGGSRAPSTL WQSPSAFSLP
REDALKMPSL ETASRPLKGP GQPPQEEAAL SSWRSTDRLD ETNLAEVLQS PDGNWVALKD
GTLPHTRLLA KPKSGTFQAL EAASSMASAY DEMGSDSEED FDWSEALSTL CPRPRGRPRN
PQPQPTQAQG SDQGPSAASS GLSPNPEAMC SDSETSSASS SREAGRRARL SWVQRKAPRD
PTAEKMRLQG ELDVNFNPQA ASRETSDSSE PEEAPHAADR KARRWRRARV GSEEPSEELS
SPNAHSQGLD VHQVSGDLSE TDISNEPRHP QTGVATTEEK LKNRLYELAM KMSEKETSSG
EDQESEPKTE SENHKESLSS EDNSQGVQEE LKKKYSAVSL CNISTEVLKV INATEELIAE
STGPWEFPPV PPDREKGTFP LGTDQVRLDE QLTSLEENVY LAAGTVYGLE GQLNELEDAA
RCIHSGTNET ELADLEDQVA TAAAQVHHAE LQISDIESRI SALTIAGLNI APCVRLTRKR
DQKQRNQVQT IDTSRQQRRK LPAPPVKAEN IEASSVTTMK TFNRNFILQG SSTNRMNERK
STTKDLVEPT LEAAVLY
//
