ID G1L7F1_AILME Unreviewed; 1867 AA.
AC G1L7F1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Ankyrin 1 {ECO:0000313|Ensembl:ENSAMEP00000002817.2};
GN Name=ANK1 {ECO:0000313|Ensembl:ENSAMEP00000002817.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000002817.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000002817.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000002817.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR STRING; 9646.ENSAMEP00000002817; -.
DR Ensembl; ENSAMET00000002937.2; ENSAMEP00000002817.2; ENSAMEG00000002547.2.
DR eggNOG; KOG4177; Eukaryota.
DR GeneTree; ENSGT00940000155760; -.
DR HOGENOM; CLU_000134_7_3_1; -.
DR TreeFam; TF351263; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08805; Death_ank1; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24198; ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24198:SF173; ANKYRIN-3; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 7.
DR Pfam; PF13637; Ank_4; 2.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 23.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 20.
DR PROSITE; PS50088; ANK_REPEAT; 20.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 77..109
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 110..142
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 143..167
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 205..237
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 238..270
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 271..303
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 304..336
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 337..369
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 370..402
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 403..435
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 436..468
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 469..501
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 502..534
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 535..567
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 568..592
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 601..633
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 634..666
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 667..699
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 700..732
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 733..765
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 912..1069
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1071..1217
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1404..1488
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 875..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1487..1516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1581..1620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1638..1675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1586..1602
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1641..1657
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1867 AA; 204935 MW; 17DCA0EC379A3492 CRC64;
MPFPRGFLKA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM
VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ
ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA
ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI
TPLHIASRRG NVIMVRLLLD RGAQIETRTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA
KTKNGLSPIH MAAQGDHLDC VRLLLQYNAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK
GAKPNSRALN GFTPLHIACK KNHIRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV
KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI
GHMNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETAL ALLEKEASQA CMTKKGFTPL
HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN HLDIVRLLLP RGGSPHSPAW
NGYTPLHIAA KQNQMEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN
GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVTVDATTRM GYTPLHVASH YGNIKLVKFL
LQHQADVNAK TKQGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSNGTTP LAIAKRLGYI
SVTDVLKVVT DEPSFVLTSD KHRLSFPETV DEILDVSEDE GEELISKAER QDSRDIDEEK
ELLDFVPKLD QVVESPAIPR IPCVTPETVV IRAEEPEQAS KEYDEDSLIP SSPATETSDN
ISPVASPVHT GFLVSFMVDA RGGSMRGSRH NGLRVVIPPR TCAAPTRITC RLVKPQKLSS
PPPLAEDEGL ASRIIALGPT GAQFLSPVIV EIPHFASHGR GDRELVVLRS ENGSVWKEHR
SRYEESDLDM DQLLNGMDEE LGSLEELEKK RVCRIITTDF PLYFVIMSRL CQDDDTIGPE
GGLLKSKLVP LVMATFPENA VIKRVKLALQ AQPVPDELVT KLLGNQATFS PIVTVEPRRR
KFYRPIGLRI PLPPSWMDNP RDSGEGDTTS LRLLCSVTGG TDQAQWEDIT GTTKLVYANE
CAAFTTNVSA RFWLSDCPRT AEAVNFATLL YRELTAVPYM AKFVIFAKMN DPREGRLRCY
CMTDDKVDKT LEQHENFVEV ARSRDIEVLE GMPLFAELFG NLVPVRKAAQ QRSFQFQSFR
ENRLAIPVKV RDSSREPAGS LSFLRKAMKY EDAQHILCHL NITMPPCTKV SSADERRRTL
TPLALRYSIL SESSLGSLSG TDRADMKMAI ISEHLGLSWA ELARELQFSV EDINRIRVEN
PNSLLEQSVA LLNLWVIREG KNANMENLYA ALRNIDRSEI MNMLEGSGRQ SRNLKPERWH
GDRDYSSSPS QMNGYSSLQD ELLSPASLHY ALPSPLRADQ YWNEVAVIDA IPLAATEHDA
MLEMSDMQVW STGLTPSLVT AEDSSLECSK AEDSDATGHE WKPEGVLSEG PQGPTLGSLD
LVEDDTVDSD AINGLIDLLD QEEGQRSEEK LPGHERQEDS AGAGQASENE VSLVSGQATV
QAHITESPSV SRVMETSQDR LQDWNEEGSI VSYLQDAAQG SWPEEVSQGT HSFQSTVTTI
QELEPSGSQE FEKVLVSATE SRERRRQSHQ AWVQEAQSTF SQMAEGSEFQ NIPGEQVTEE
QFTDEQGNIV TKKIIRKVIR QIDSSGADDT QELEEVELRG SSLQPDLIES RKGAQIVKRA
SLKRGKQ
//
