ID G1LNT6_AILME Unreviewed; 551 AA.
AC G1LNT6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Keratin, type I cytoskeletal 10 {ECO:0000256|ARBA:ARBA00040327};
DE AltName: Full=Cytokeratin-10 {ECO:0000256|ARBA:ARBA00041708};
DE AltName: Full=Keratin-10 {ECO:0000256|ARBA:ARBA00042491};
GN Name=KRT10 {ECO:0000313|Ensembl:ENSAMEP00000008714.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000008714.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000008714.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000008714.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000256|ARBA:ARBA00004241}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Secreted, extracellular
CC space {ECO:0000256|ARBA:ARBA00004239}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR AlphaFoldDB; G1LNT6; -.
DR Ensembl; ENSAMET00000009085.2; ENSAMEP00000008714.2; ENSAMEG00000028027.1.
DR GeneTree; ENSGT00940000160849; -.
DR InParanoid; G1LNT6; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF137; KERATIN, TYPE I CYTOSKELETAL 10; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 141..455
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 145..430
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 523..544
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 551 AA; 56275 MW; E2761E459F84C7F0 CRC64;
MSVRYSSSKQ YSSSRSGGGG GGGGGSSFRI SSSKGSIGGG FSSGGFSGGS FSRGSSGGGC
FGGSSGGYGG LGGGFGGGSF GGGYGGSSFG GVCGGGSFGG GSFGGGSFGG GSFGGGGFGG
GGFGGYGGGF GGDGGLLSGN EKVTMQNLND RLASYLDKVR ALEESNYELE GKIKEWYEKH
GNSRQREPRD YSKYYQTIED LKNQILNLTT DNANILLQID NARLAADDFR LKYENEVALR
QSVEADINGL RRVLDELTLT KADLEMQIES LTEELAYLKK NHEEEMKDLQ NVSTGDVNVE
MNAAPGVDLT ELLNNMRNQY EQLAEQNRKD AEAWFNEKSK ELTTEINSNI EQMSSHKSEI
TELRRTVQGL EIELQSQLAL KQSLESSLAE TEGRYCVQLS QIQAQISSLE EQLQQIRAET
ECQNAEYQQL LDIKIRLENE IQTYRSLLEG EGSSGGGSYG GGRGGGSSGG GYGGSSGGGG
GYGGSSGGGG YGGGSSGGGG YGGGSSGGGG HGGSGHGGSS GGGYGGGSSS GGHKSSSSGS
VGEPSSKGPR Y
//
