ID G1LNX0_AILME Unreviewed; 494 AA.
AC G1LNX0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Keratin 12 {ECO:0000313|Ensembl:ENSAMEP00000008750.2};
GN Name=KRT12 {ECO:0000313|Ensembl:ENSAMEP00000008750.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000008750.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000008750.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000008750.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR AlphaFoldDB; G1LNX0; -.
DR STRING; 9646.ENSAMEP00000008750; -.
DR Ensembl; ENSAMET00000009123.2; ENSAMEP00000008750.2; ENSAMEG00000008309.2.
DR eggNOG; ENOG502QTM6; Eukaryota.
DR GeneTree; ENSGT00940000159382; -.
DR HOGENOM; CLU_012560_8_3_1; -.
DR InParanoid; G1LNX0; -.
DR TreeFam; TF332742; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0061303; P:cornea development in camera-type eye; IEA:Ensembl.
DR GO; GO:0002009; P:morphogenesis of an epithelium; IEA:Ensembl.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF369; KERATIN, TYPE I CYTOSKELETAL 12; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 126..442
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 130..164
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 234..313
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 340..374
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 494 AA; 53249 MW; D71B5F5A0CAABBF3 CRC64;
VDLSSNTMSL SVRTSGLPRR LSSQSGTSGR ARGTTASIVG SSYGGSTFGF GDSCGGGFSA
ASMFGSSSGF GGGSGISFAG GLGTAYGGAL GGGGFGGLGI GFGGGPGGGS VGILSGNDGG
LLSGSEKETM QNLNDRLASY LDKVRALEEA NAELENKIRE WYETRGSGTG DPGSQSDYSK
YYPLIEDLRN EIISASIGNA QLILQIDNAR LAAEDFRMKY ENELALHQSV EADINGLRRV
LDELTLARAD LEMQIENLTE ELAYLKKNHE EELQSFRAGG PGEISVEMDA APAVDLTRLL
NNMRAQYETI AEQNRKDAEA WFIEKSGELR KEISTNTEQL QSSKSEVTDL RRAVQNLEIE
LQSQLATKKS LEVSLAEVEG DYCGQLSQVQ QLIGSLEEQL LQVRTDTEHQ NADHQRLLNA
KARLELEIET YRRLLDGEAQ GDSFDETLYV TESKPQTQSI DSSKEQSKSR KIKTIVQEVV
NGEVVSSQVQ EDLM
//
