ID G1LPE9_AILME Unreviewed; 550 AA.
AC G1LPE9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Guanine nucleotide-binding protein-like 3 {ECO:0000256|ARBA:ARBA00016532};
GN Name=GNL3 {ECO:0000313|Ensembl:ENSAMEP00000008929.1};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000008929.1, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000008929.1, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000008929.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_011222928.1; XM_011224626.2.
DR AlphaFoldDB; G1LPE9; -.
DR STRING; 9646.ENSAMEP00000008929; -.
DR Ensembl; ENSAMET00000009312.2; ENSAMEP00000008929.1; ENSAMEG00000008456.2.
DR GeneID; 100483675; -.
DR KEGG; aml:100483675; -.
DR CTD; 26354; -.
DR eggNOG; KOG2484; Eukaryota.
DR GeneTree; ENSGT00940000158320; -.
DR HOGENOM; CLU_011106_5_6_1; -.
DR InParanoid; G1LPE9; -.
DR OMA; FKLDGLW; -.
DR OrthoDB; 2879109at2759; -.
DR TreeFam; TF313085; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IEA:Ensembl.
DR GO; GO:0048027; F:mRNA 5'-UTR binding; IEA:Ensembl.
DR GO; GO:1902895; P:positive regulation of miRNA transcription; IEA:Ensembl.
DR GO; GO:1904816; P:positive regulation of protein localization to chromosome, telomeric region; IEA:Ensembl.
DR GO; GO:0033235; P:positive regulation of protein sumoylation; IEA:Ensembl.
DR GO; GO:0032206; P:positive regulation of telomere maintenance; IEA:Ensembl.
DR GO; GO:0017145; P:stem cell division; IEA:Ensembl.
DR GO; GO:0019827; P:stem cell population maintenance; IEA:Ensembl.
DR CDD; cd04178; Nucleostemin_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030378; G_CP_dom.
DR InterPro; IPR014813; Gnl3_N_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11089; GTP-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR11089:SF11; GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3; 1.
DR Pfam; PF08701; GN3L_Grn1; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR PRINTS; PR00326; GTP1OBG.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51721; G_CP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 131..311
FT /note="CP-type G"
FT /evidence="ECO:0000259|PROSITE:PS51721"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 72..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..44
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..95
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..485
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 550 AA; 61843 MW; 3F52DB73D4691B29 CRC64;
MKRPKLKKAS KRMTCHKRYK IQKKVREHHR KLRKEAKKRG CKKPRKDPGV PNSAPFKEAL
LREAELRKQR LEELKQQQKL DRQKEQEKKR KLETNSGVKP SNLEPVKEEF GQGKAKDKPK
SGKQNPKKLY CQELKKVIEA ADVVLEVLDA RDPLGCRCPQ VEEAIIQSGQ KKLVLVLNKS
DLVPKENLEN WLNYLKKELP TVVFRASTNL KDKGKIIKHL KVRKRAPFKS EVCVGKDGLW
KLLRGFQEAY GKAIQVGVIG FPNVGKSSII NSLKQERICN VSVSMGLTRC MQVVPLDKQI
TVLDSPSFIV SPLNSASALA LRSPASIEVL KPVEAASAIL SQADARQVVL KFTIPDFKSP
LEFFTSLAQR RGLHRKGGSP NLEGAAKLMW SEWTGASLGY YCHPPTSWTP SPHFNEGIVT
DMKRGLNLEE LEKNNAHSIQ TVRGPRLASS ILFQSSGLTN GIIEEKDIPE EPPKQKEKKQ
EEGEDYNELD SDQEIVDEEA GEKSSDVSGA GEAWEALPEE SQADESAPSY ISDKMTEEED
DAYDFSIDYV
//
