GenomeNet

Database: UniProt
Entry: G1LQ73_AILME
LinkDB: G1LQ73_AILME
Original site: G1LQ73_AILME 
ID   G1LQ73_AILME            Unreviewed;       805 AA.
AC   G1LQ73;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   30-AUG-2017, entry version 47.
DE   SubName: Full=Two pore segment channel 1 {ECO:0000313|Ensembl:ENSAMEP00000009203};
GN   Name=TPCN1 {ECO:0000313|Ensembl:ENSAMEP00000009203};
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
OC   Ailuropoda.
OX   NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000009203, ECO:0000313|Proteomes:UP000008912};
RN   [1] {ECO:0000313|Ensembl:ENSAMEP00000009203}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q.,
RA   Li B., Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H.,
RA   Jian M., Li J., Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z.,
RA   Ryder O.A., Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X.,
RA   Guo X., Wang B., Hou R., Shen F., Mu B., Ni P., Lin R., Qian W.,
RA   Wang G., Yu C., Nie W., Wang J., Wu Z., Liang H., Min J., Wu Q.,
RA   Cheng S., Ruan J., Wang M., Shi Z., Wen M., Liu B., Ren X., Zheng H.,
RA   Dong D., Cook K., Shan G., Zhang H., Kosiol C., Xie X., Lu Z.,
RA   Zheng H., Li Y., Steiner C.C., Lam T.T., Lin S., Zhang Q., Li G.,
RA   Tian J., Gong T., Liu H., Zhang D., Fang L., Ye C., Zhang J., Hu W.,
RA   Xu A., Ren Y., Zhang G., Bruford M.W., Li Q., Ma L., Guo Y., An N.,
RA   Hu Y., Zheng Y., Shi Y., Li Z., Liu Q., Chen Y., Zhao J., Qu N.,
RA   Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X., Vinar T., Wang Y.,
RA   Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y., Wang X.,
RA   Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H.,
RA   Wang J., Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
RN   [2] {ECO:0000313|Ensembl:ENSAMEP00000009203}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSAMEP00000009203}.
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DR   EMBL; ACTA01083799; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSAMET00000009599; ENSAMEP00000009203; ENSAMEG00000008697.
DR   eggNOG; ENOG410INF7; Eukaryota.
DR   eggNOG; ENOG410XZT8; LUCA.
DR   GeneTree; ENSGT00530000063660; -.
DR   InParanoid; G1LQ73; -.
DR   OMA; WLGFHTF; -.
DR   OrthoDB; EOG091G038K; -.
DR   TreeFam; TF328550; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0072345; F:NAADP-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028801; TPC1.
DR   PANTHER; PTHR10037:SF262; PTHR10037:SF262; 1.
DR   Pfam; PF00520; Ion_trans; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008912};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    104    126       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    132    150       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    232    251       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    258    277       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    297    320       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    442    462       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    474    492       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    504    523       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    567    591       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    663    688       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      110    327       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      438    687       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   805 AA;  93044 MW;  899A10CB58231371 CRC64;
     MAVSLDDDVP LILTLDEGGG APLAPSNGLG QEELPSRNGG SYAVHDSRTP SLGSGGESPT
     GHNWEINYQE AAIYLQEGEN NDKFFTHPKN AKALAAYLFA HNHLFYLMEL STALLLLLLS
     LCEAPAVPAL RLGIYVHATL ELFALMVVVF ELCMKLRWLG LHTFIRHKRT MVKTSVLVVQ
     FIEAIVVLVR QTSHVRVTRA LRCIFLVDCR YCGGVRRNLR QIFQSLPPFM DILLLLLFFM
     VIFAILGFYL FSPNPSDPYF STLENSIVSL FVLLTTANFP DVMMPSYSRN PWSCVFFIVY
     LSIELYFIMN LLLAVVFDTF NDIEKRKFKS LLLHKRTAIQ HAYRLLISQR RPAGISYRQF
     EGLMRFYRPR MGARERYLTF KALNQSNTPL LSLKDFYDIY EVAALKWKAK RNREHWFDEL
     PRTAFLIFKG VNILVKSKAF QYFMYLVVAV NGVWILVETF MLKGGNFFSK HVPWSYIVFL
     TIYGVELFLK VAGLGPVEYL SSGWNLFDFS VTVFAFLGLL ALAFNMEPFY FIVVLRPLQL
     LRLFKLKKRY RNVLDTMFEL LPRMASLGLT LLIFYYSFAI VGMEFFCGIL YPNCCNTSTV
     ADAYRWLNHT MGNKTVVDEG YYYLNNFDNI LNSFVTLFEL TVVNNWYIIM EGVTSQTSHW
     SRLYFMTFYI VTMVVMTIIV AFILEAFVFR MNYSRKNQDS EVDSGITLEK EISKDELVAV
     LELYQEVRGA TSDIAWLLKV LSQMEKHEQN TVVFLGRRSR TKSDLSLKMY QEEIQEWYEE
     HAREQQQVPA TQQLPGSRQR AQTIT
//
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