ID G1LQ73_AILME Unreviewed; 815 AA.
AC G1LQ73;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Two pore segment channel 1 {ECO:0000313|Ensembl:ENSAMEP00000009203.2};
GN Name=TPCN1 {ECO:0000313|Ensembl:ENSAMEP00000009203.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000009203.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000009203.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000009203.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G1LQ73; -.
DR STRING; 9646.ENSAMEP00000009203; -.
DR Ensembl; ENSAMET00000009599.2; ENSAMEP00000009203.2; ENSAMEG00000008697.2.
DR eggNOG; KOG2301; Eukaryota.
DR GeneTree; ENSGT00940000158958; -.
DR HOGENOM; CLU_019500_0_0_1; -.
DR InParanoid; G1LQ73; -.
DR TreeFam; TF328550; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0031901; C:early endosome membrane; IEA:Ensembl.
DR GO; GO:0036019; C:endolysosome; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:Ensembl.
DR GO; GO:0097682; F:intracellular phosphatidylinositol-3,5-bisphosphate-sensitive monatomic cation channel activity; IEA:Ensembl.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:Ensembl.
DR GO; GO:0072345; F:NAADP-sensitive calcium-release channel activity; IEA:Ensembl.
DR GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0019905; F:syntaxin binding; IEA:Ensembl.
DR GO; GO:0022832; F:voltage-gated channel activity; IEA:InterPro.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR GO; GO:0075509; P:endocytosis involved in viral entry into host cell; IEA:Ensembl.
DR GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR028801; TPC1_animal.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR46474; TWO PORE CALCIUM CHANNEL PROTEIN 1; 1.
DR PANTHER; PTHR46474:SF1; TWO PORE CHANNEL PROTEIN 1; 1.
DR Pfam; PF00520; Ion_trans; 2.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 104..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 132..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 442..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 474..492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 504..523
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 567..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 663..688
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 105..327
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 438..688
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 22..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 781..815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..815
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 815 AA; 94114 MW; 8C18851AD55F065B CRC64;
MAVSLDDDVP LILTLDEGGG APLAPSNGLG QEELPSRNGG SYAVHDSRTP SLGSGGESPT
GHNWEINYQE AAIYLQEGEN NDKFFTHPKN AKALAAYLFA HNHLFYLMEL STALLLLLLS
LCEAPAVPAL RLGIYVHATL ELFALMVVVF ELCMKLRWLG LHTFIRHKRT MVKTSVLVVQ
FIEAIVVLVR QTSHVRVTRA LRCIFLVDCR YCGGVRRNLR QIFQSLPPFM DILLLLLFFM
VIFAILGFYL FSPNPSDPYF STLENSIVSL FVLLTTANFP DVMMPSYSRN PWSCVFFIVY
LSIELYFIMN LLLAVVFDTF NDIEKRKFKS LLLHKRTAIQ HAYRLLISQR RPAGISYRQF
EGLMRFYRPR MGARERYLTF KALNQSNTPL LSLKDFYDIY EVAALKWKAK RNREHWFDEL
PRTAFLIFKG VNILVKSKAF QYFMYLVVAV NGVWILVETF MLKGGNFFSK HVPWSYIVFL
TIYGVELFLK VAGLGPVEYL SSGWNLFDFS VTVFAFLGLL ALAFNMEPFY FIVVLRPLQL
LRLFKLKKRY RNVLDTMFEL LPRMASLGLT LLIFYYSFAI VGMEFFCGIL YPNCCNTSTV
ADAYRWLNHT MGNKTVVDEG YYYLNNFDNI LNSFVTLFEL TVVNNWYIIM EGVTSQTSHW
SRLYFMTFYI VTMVVMTIIV AFILEAFVFR MNYSRKNQDS EVDSGITLEK EISKDELVAV
LELYQEVRGA TSDIAWLLKV LSQMEKHEQN TVVFLGRRSR TKSDLSLKMY QEEIQEWYEE
HAREQEERQR QLGGSGQVPA TQQLPGSRQR AQTIT
//
