ID G1LXA3_AILME Unreviewed; 1385 AA.
AC G1LXA3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=ATPase family AAA domain containing 2 {ECO:0000313|Ensembl:ENSAMEP00000011706.2};
GN Name=ATAD2 {ECO:0000313|Ensembl:ENSAMEP00000011706.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000011706.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000011706.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000011706.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_002924373.1; XM_002924327.3.
DR STRING; 9646.ENSAMEP00000011706; -.
DR Ensembl; ENSAMET00000012203.2; ENSAMEP00000011706.2; ENSAMEG00000011109.2.
DR eggNOG; KOG0732; Eukaryota.
DR GeneTree; ENSGT00550000074694; -.
DR HOGENOM; CLU_001448_3_2_1; -.
DR InParanoid; G1LXA3; -.
DR TreeFam; TF314783; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR CDD; cd05528; Bromo_AAA; 1.
DR CDD; cd19517; RecA-like_Yta7-like; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR045199; ATAD2-like.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23069; AAA DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR23069:SF4; ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00297; BROMO; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00674; AAA; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 1001..1056
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 70..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 215..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1104..1155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1176..1233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..280
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1176..1202
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1385 AA; 157775 MW; 88EC10B24144FB9B CRC64;
MVVLRSSLEL HSHSASSATD PLDLSNEFLS LEQIGRRRLR SARAAEQSAV TVAAAGDGSS
VKEVESYHRT RSLRSLRKNA QNSSDSSFDK NMEITEKHAN GRHFTRQSAR QQADKKKEEC
KEDKVIPVTR SLRTRNIVQT KEHLHEENGD VEVRRSCRIR SRYSSVNQSV LFDKLITNTA
EAVLQKMDDM KKMRRQRMRE LEDLGVFNET EEENINMYTR GKQKGIQRTD EETTDNQEGS
VESSEEGEDQ EDEDDGEDEE DDEDDDDDDE DDEDEEDGEE DNQKRYYLRQ RKATVYYQAP
LEKPRHQRKP NIFYSGPASP ARPRYRLSSA GPRSPYCKRM NRRRHAIHSS DSTSSSSSED
EQQFERRRKR SRNRAINRCL PLNFRKDELK GIYKDRMKIG ASLADVDPMQ LDSSVRFDSI
GGLSNHIAAL KEMVVFPLLY PEVFEKFRIQ PPRGCLFYGP PGTGKTLVAR ALANECSQGD
KRVAFFMRKG ADCLSKWVGE SERQLRLLFD QAYQMRPSII FFDEIDGLAP VRSSRQDQIH
SSIVSTLLAL MDGLDSRGEI VVIGATNRLD SIDPALRRPG RFDREFLFSL PDKDARKEIL
KIHTRDWNPK PLDIFLEELA ENCVGYCGAD IKSICSEAAL CALRRRYPQI YTTSEKLQLD
LSSINISAKD FEVAMQKMIP AAQRAVASPG QALSTVVKPL LQSTVHKILE ALQRVFPHAE
IRTNKALDSD ISCPLLESDL AYSDDDVPSV YENGLSQKSF NKAKENFNFL HLNRNACYQP
MSFRPRILIV GEPGFGQGSH LAPAVIHALE KFAVYTLDIP VLFGVSATSP EETCAQMIRE
AKRTAPSIVY VPHIHLWWEI VGPTLKATFT TLLQNIPSFA PVLLLATSDK PHSALPEEVQ
ELFIRDYGEI FNVQLPGKEE RTKFFEDLIL KQAAKSPLSK KKAVLQALEV LPVAPPPEPR
PLTVEEVKRL EEQEEDTFRE LRIFLRNVTH RLAIDKRFRV FTKPVDPDEV PDYVTVIKQP
MDLSSVISKI DLHKYLTVKD YLSDIDLICS NALEYNPDRD PGDRLIRHRA CALRDTAYAI
IKEELDEDFE QLCEEIQESR KKRGCSSSKY APSYYHVMPK QNSTSAGDKR SDPEQNEKLK
TTSTPMACST PAQLKRKIRK KSKWYLGTIT KRRRISQVKD ESQNITDDKI ESDTEENQDT
SADHNETGNT GESSVEENEK HQNASESRIE LGNNNSSICG IENEFEESGK TTACTEVRKD
KVVCNGVASG SQIIDISDEN EAKEMCVLRM TRARRSQVQQ QQLISVEKAL AILSQPTPSL
VVDHERLKNL LKTVVKKSQE YNIFQLENLY AVISQCIYQH RMDYDKTTLI QKMEQEVQNF
SCSRS
//
