ID G1LYV8_AILME Unreviewed; 1548 AA.
AC G1LYV8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=ERCC excision repair 6 like 2 {ECO:0000313|Ensembl:ENSAMEP00000012265.2};
GN Name=ERCC6L2 {ECO:0000313|Ensembl:ENSAMEP00000012265.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000012265.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000012265.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000012265.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC {ECO:0000256|ARBA:ARBA00007025}.
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DR STRING; 9646.ENSAMEP00000012265; -.
DR Ensembl; ENSAMET00000012786.2; ENSAMEP00000012265.2; ENSAMEG00000011657.2.
DR eggNOG; KOG0387; Eukaryota.
DR GeneTree; ENSGT00940000163752; -.
DR HOGENOM; CLU_000315_17_10_1; -.
DR InParanoid; G1LYV8; -.
DR TreeFam; TF351516; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd18005; DEXHc_ERCC6L2; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR029256; Heliccase-ass-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45629:SF7; DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED; 1.
DR PANTHER; PTHR45629; SNF2/RAD54 FAMILY MEMBER; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR Pfam; PF14773; VIGSSK; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 133..319
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 510..660
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 714..782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 926..951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 972..1029
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1344..1374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..737
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 760..774
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..951
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 975..998
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1352..1374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1548 AA; 175813 MW; 66481F11E134F471 CRC64;
MPRHNFSKIH AYSDIWNPGE RCLAPSPENG TLCEASIKSI TVDENGKSFA IILYSDFQER
KVPLKRLQEV KSVKDCSRSF IFDDEDLEKP YFPDRKFPSS AVAFPLSEDG DSIPYTINRY
LRDYQREGAQ FLYAHFIQGK GCILGDDMGL GKTVQVISFL AAVLHKKGTR EDIENNMPEF
LLRSMKKEPP CSIAKKMFLI VAPLSVLYNW RDELDTWGYF RVTILHGNKK DNELIRVKQR
KCEIALTTYE TLRLCLEELN SLEWSAVIVD EAHRIKNPKA RITEVMKALK CNVRIGLTGT
ILQNNMKELW CVMDWAVPGL LGSRIHFKKQ FSDPVEHGQR HTATKRELAT GRKAMQRLAK
KMSGWFLRRT KTLIKDQLPK KEDRMVYCSL TDFQKAVYQT VLETKDVTLI LQSSEPCSCS
SGRKRRNCCY KTNSHGETVK TLYFSYLAVL QKVANHVALL QSASTSKHQE TLIKRICDQV
FSKFPDFVQK SKDSAFETLS DPKYSGKMKV LQQLLNHCRK NKDKILLFSF STKLLDVLQQ
YCMAAGLDYR RLDGSTKSEE RIKIVKEFNS TQDVNICLVS TMAGGLGLNF VGANVVVLFD
PTWNPANDLQ AIDRAYRIGQ CRDVKVFRLI SLGTVEEIMY LRQVYKQQLH CVVVGSENAK
RYFEAVQGSK EHRGELFGVY NLFKLRSQGS CLTRDILERE GKVEAGIMTA TTWLKEEPPV
HKQETSIEPD RQEQGDLEQA AESPTREACD ICSDFSDDEP VGNSRMKTAK HKASDSSKAS
GSPGQLTLLH CGFSKLFETK YKAVEDSDGN IASDDESSDE QPMCLSTEAK DVGYQKSHDS
LGTSKHQKLA NILNPNEKCI FDKSEKIFKQ NISSESDEEK IFKNTADHHC ILQNVTESED
SDVVFPTQYT TQTCPKNGIK FKSLVNESQD SETENPVKIR SNGDDRKTGV KGNRLISKQL
NPENVTLKSI MKRKGSSGIS DESDDIEISS ESRARKRRAT SSLRFKRKKE TKKELVTSET
KKKTNQLNAA DGDCNSQAID DFSSSDDDLT LHHINFSKQS RTPKTIKDKI SFSSKLPNHK
ENGTLMPRKS MKFSNEKVVH QQQVYESMDK FLDGVQEVAY IHSNQTVIGS SKAENHMSRW
AARDVFELKQ FSQLPANVAV CTSKTHKEKV KTDTLTRTKK GQQLSGGSIS FPLYISHPVS
QKKKKVYRTD QTTFIIGETP KGIRTKQFEE MASYFNLPSV KEFAEHITNA TSEERQKMLK
DFYASQYPEV KEFFVDSAAE FIKSSHQKRE RVRNKSEKRK SLIKERLSDF ETLSFKDSPK
KGSQICSPKI YKEKSVKFQN HSFHGEEVLS NDGETNESPI NSTEETDNGK SSQAFKDTVA
SCSLNSESEV YELEKLEYTV KDQQDLTRTG ISRTEPLFKV ENKKIENPEL GNTSVVGLLG
DTSILDDLFK SHGNSPTQLP KKVLSGPMEK AKQRPKDFWD ILNEQNDDSL SKLTDLAVIE
TLCEKVPLAA SSKRKEELET SLWKSNEKFL WKKFSSSDTD ENTTNAQK
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