ID G1M2X5_AILME Unreviewed; 1328 AA.
AC G1M2X5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=FA complementation group I {ECO:0000313|Ensembl:ENSAMEP00000013686.2};
GN Name=FANCI {ECO:0000313|Ensembl:ENSAMEP00000013686.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000013686.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000013686.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000013686.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_002919611.1; XM_002919565.3.
DR STRING; 9646.ENSAMEP00000013686; -.
DR Ensembl; ENSAMET00000014257.2; ENSAMEP00000013686.2; ENSAMEG00000012957.2.
DR Ensembl; ENSAMET00000034172.1; ENSAMEP00000037827.1; ENSAMEG00000012957.2.
DR Ensembl; ENSAMET00000036262.1; ENSAMEP00000029118.1; ENSAMEG00000012957.2.
DR Ensembl; ENSAMET00000043281.1; ENSAMEP00000023805.1; ENSAMEG00000012957.2.
DR Ensembl; ENSAMET00000044849.1; ENSAMEP00000041142.1; ENSAMEG00000012957.2.
DR GeneID; 100476137; -.
DR KEGG; aml:100476137; -.
DR CTD; 55215; -.
DR eggNOG; KOG4553; Eukaryota.
DR GeneTree; ENSGT00390000005855; -.
DR HOGENOM; CLU_004843_1_0_1; -.
DR TreeFam; TF323694; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:1990391; C:DNA repair complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0070182; F:DNA polymerase binding; IEA:Ensembl.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
DR CDD; cd11720; FANCI; 1.
DR InterPro; IPR026171; FANCI.
DR InterPro; IPR029310; FANCI_HD1.
DR InterPro; IPR029312; FANCI_HD2.
DR InterPro; IPR029308; FANCI_S1.
DR InterPro; IPR029305; FANCI_S1-cap.
DR InterPro; IPR029315; FANCI_S2.
DR InterPro; IPR029313; FANCI_S3.
DR InterPro; IPR029314; FANCI_S4.
DR PANTHER; PTHR21818; BC025462 PROTEIN; 1.
DR PANTHER; PTHR21818:SF0; FANCONI ANEMIA GROUP I PROTEIN; 1.
DR Pfam; PF14679; FANCI_HD1; 1.
DR Pfam; PF14680; FANCI_HD2; 1.
DR Pfam; PF14675; FANCI_S1; 1.
DR Pfam; PF14674; FANCI_S1-cap; 1.
DR Pfam; PF14676; FANCI_S2; 1.
DR Pfam; PF14677; FANCI_S3; 1.
DR Pfam; PF14678; FANCI_S4; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 1..53
FT /note="FANCI solenoid 1 cap"
FT /evidence="ECO:0000259|Pfam:PF14674"
FT DOMAIN 64..280
FT /note="FANCI solenoid 1"
FT /evidence="ECO:0000259|Pfam:PF14675"
FT DOMAIN 284..370
FT /note="FANCI helical"
FT /evidence="ECO:0000259|Pfam:PF14679"
FT DOMAIN 378..541
FT /note="FANCI solenoid 2"
FT /evidence="ECO:0000259|Pfam:PF14676"
FT DOMAIN 555..782
FT /note="FANCI helical"
FT /evidence="ECO:0000259|Pfam:PF14680"
FT DOMAIN 800..1025
FT /note="FANCI solenoid 3"
FT /evidence="ECO:0000259|Pfam:PF14677"
FT DOMAIN 1038..1288
FT /note="FANCI solenoid 4"
FT /evidence="ECO:0000259|Pfam:PF14678"
FT REGION 1294..1328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 685..716
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1328 AA; 149026 MW; 473EF2251E46A2A9 CRC64;
MDQKIISLAA EKTADRLQEF LQTLKEDDLA NLLQNQAVKG RAAGALLRAI FKGSPCSEEA
GALRRLKIYV CCIHLVESGD LQKEVASEII GLLMLEAHNF PGSLLVELAK EFIGAIKEGS
LTNGKSLELL PIILSALVAN KENLAYGKGA LSGEECKKQL INTLCSGRWD QQYVIQLTSM
FKDVPLTAEE VEFVVEKVLR MFSKLNLQEI PPLVYQLLVL SSKGSRRRAL EGIITFFNEL
DKQHNEEQSG DELLDLVTVP SGELRHVEGT IILHIVFAIK LDCELGRELL KHLKAGQQGD
FSNNICPFSI ALLLSVTRIQ RFEEQVFDLL KASVVKSFKD LQLLQGSKFL QNLVPHRSCV
STMILEVVKN SVHSWDHVTQ GLVELGFILM DSYGPKKILD GKTIETSSGL SKTSNQHACK
LGAKILLETF KIHEMIRQEI LEQVLNRVVT RASSPISHFL DLLSNIIMYA PLVLQSCSSK
ITETFEYLSF LPLQTVQGLL KAVQPLLKVS MSVRDSLILV LRKAMFASQL DARKSAVAGF
LLLLKNFKVL GSLSSSQCSQ SIGISQVHVD VHSRYNSVAN ETFCLEIMDS LRRCLGQQAD
VRLMLYEGFY DVLRRNSQLA NSVMQTLLSQ LKQFYEPGPD VLPPLKLEAC ILTQGDEISL
QEPLDHLLCC VQHCLVWCKS RVMPLQQEEE EEEEFYQDLE EMLESVTSRM IKSELEDFEL
DKSADFSQST SVGIKNSICA SLVMGICEVL IEYNFSISNF SKNKFEEVLS LFMCYKKLSD
ILNEKAGKGK TKTANKMDSF WSMKFVSDLL TALFRDSAQS HEESLSVLRS SPEFMRHAVS
VALQKVQQLK ETGHVSGPDG QNPEKVFQNL CDITRVLLWR YTSIPTSVED LGKKEKGKSI
SLLCLEGLQK IFSAVQQFYQ PRIHQFLRAL DVTDSKGEEV EGSVTHRAAF QIRQFQRSLL
NLLSSQEEDF HSKEALLLVT VLSNLSKLLE PSSPQFVQML SWTLKICKEN SQEDASFCKG
LMSLLFSLHV LYKSPVILLR DLSQDIHGHL GDIDQDVGVE KTDHFAVVNL RTAAPTVCLL
VLSQAEKVLE EVDWLITKLK GQVSQEIVSE EASSQATRPN HPIEKAIIMQ LGTLLTFFHE
LVQTALPSGS CVDILLKDLC KMYTILTALV RYYLQVCPSS GGIPKNMEKL VKLSGSHLTP
LCYSFISYIQ NKKSQSLKCT GEKKGKAAAV AIAMARVLRE TKPIPNLIFA IEQYEKFLIH
LSKKSKVNLM QHMKLSTSRD FKIKGNILDM VLREDEDDGH EKGTTSEHEG QNREPAKKKR
KKEMPELM
//
