ID G1MAI8_AILME Unreviewed; 1098 AA.
AC G1MAI8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=GPI ethanolamine phosphate transferase 3 {ECO:0000256|ARBA:ARBA00020841};
GN Name=PIGO {ECO:0000313|Ensembl:ENSAMEP00000016362.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000016362.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000016362.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000016362.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
CC {ECO:0000256|ARBA:ARBA00008695}.
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DR RefSeq; XP_019665433.1; XM_019809874.1.
DR AlphaFoldDB; G1MAI8; -.
DR STRING; 9646.ENSAMEP00000016362; -.
DR Ensembl; ENSAMET00000017041.2; ENSAMEP00000016362.2; ENSAMEG00000015510.2.
DR GeneID; 100470556; -.
DR KEGG; aml:100470556; -.
DR CTD; 84720; -.
DR eggNOG; KOG2126; Eukaryota.
DR GeneTree; ENSGT00910000144278; -.
DR HOGENOM; CLU_004298_2_0_1; -.
DR InParanoid; G1MAI8; -.
DR TreeFam; TF354249; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051377; F:mannose-ethanolamine phosphotransferase activity; IEA:Ensembl.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd16023; GPI_EPT_3; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR037675; PIG-O_N.
DR InterPro; IPR039524; PIGO/GPI13.
DR PANTHER; PTHR23071:SF1; GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3; 1.
DR PANTHER; PTHR23071; PHOSPHATIDYLINOSITOL GLYCAN; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 15..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..510
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 517..536
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 548..570
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 582..599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 677..697
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 709..731
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 743..769
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 840..859
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 866..888
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 953..972
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1025..1045
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1057..1079
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1098 AA; 119571 MW; 01D9EFA2F7E137D6 CRC64;
MNSLPATSRM QKISVLLFLA WVGFLFYAGI ALFTSGFLLT RLELTNHSSC QELPGPESQP
WGSQGKPGAC WMASRFSRVV LVLIDALRFD FAQPQPSHGP GEPPVSLPFL GKLNSLQRIL
EIQPHHAKLY QSKADPPTTT MQRLKALTTG SLPTFIDAGS NFASHAIVED NLIKQLTSAG
RRVVFMGDDT WKDLFPGAFS QAFFFPSFNV RDLHTVDNGI LEHLYPTMDS GEWDMLIAHF
LGVDHCGHKY GPHHPEMAKK LSQMDQVIQG LVERLENDTL LVVIGDHGMT VTGDHGGDSE
LEISAALFLY SPKALFPGAP PEEPEVVPQI SLVPTLALLL GLPIPFGNIG EVMAELFSEV
EDSQPHSSAL AQASALHLNA QQVSRFLHTY SAAAQDLQVK ELHRLQNLFS KASADYQRLL
QSPQGAEAAL QTVITELQQF LRGVRAMCIQ SWARFSLGRM AGGAALMAAA CFLCLLVSQW
LISPGFCFRP LLLTPMACGL AGTIVCAGLL TTTGLKLDPV VLGAMAAVGS LLPFLWKAWA
GWGSKRPLVT LLPIPGPVLL FLLIRFAAFF SDSFVVAEAR ATPFLLGSLI LLLVAQLHWE
GKLLPSKLLT IPRLCFSAST GPPQRNGTHA LGLGVGLLLC IRLAGLFHRC PEETPACHSS
PWLSPLASMV GGRAKNLWYG ACVGALVVLL AAVRLWLRRY SNLKSPEPSV LFVRWGLPLM
VLGTAAYWAL ASGADEAPPR LRALVAGASV VLPRAVAGLA ASGLVLLLWR PVTVIVKATT
GAPRPRTVLT PFSGPPTSQA DLDYVVPQIY RHMQEEFRGR LERTKSQGPL TVAAYQLGSV
YSAAMVTALT LLAFPLLLLH AERISLVFLL LFLQSFLLLH LLAAGIPITT PGPFTVPWQA
VSAWALMATQ TFYSMGHQPV FPAIHWHAAF VGFPEGHGSS TWLPALLVGA NTFASHLLFA
VGCPLLLLWP FLCESQGPRK RWQPLGNEAE ARVRPEVEEE PLMEMRLREA PHHFNAALLQ
LGLKYLFVLG IQILACALAA SILRRHLMVW KVFAPKFIFE ALGFIVSSVG LFLGIALVMR
VDGAVSSWFR QLVLAQQR
//
