ID G1MDF6_AILME Unreviewed; 3560 AA.
AC G1MDF6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Spectrin beta, non-erythrocytic 5 {ECO:0000313|Ensembl:ENSAMEP00000017384.2};
GN Name=SPTBN5 {ECO:0000313|Ensembl:ENSAMEP00000017384.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000017384.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000017384.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000017384.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 9646.ENSAMEP00000017384; -.
DR Ensembl; ENSAMET00000018095.2; ENSAMEP00000017384.2; ENSAMEG00000016420.2.
DR eggNOG; KOG0517; Eukaryota.
DR GeneTree; ENSGT00940000161549; -.
DR InParanoid; G1MDF6; -.
DR TreeFam; TF313446; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0045179; C:apical cortex; IEA:Ensembl.
DR GO; GO:0030863; C:cortical cytoskeleton; IEA:Ensembl.
DR GO; GO:0005875; C:microtubule associated complex; IEA:Ensembl.
DR GO; GO:0032391; C:photoreceptor connecting cilium; IEA:Ensembl.
DR GO; GO:0097381; C:photoreceptor disc membrane; IEA:Ensembl.
DR GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
DR GO; GO:0034452; F:dynactin binding; IEA:Ensembl.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0019894; F:kinesin binding; IEA:Ensembl.
DR GO; GO:0032029; F:myosin tail binding; IEA:Ensembl.
DR GO; GO:0002046; F:opsin binding; IEA:Ensembl.
DR GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR GO; GO:0030507; F:spectrin binding; IEA:Ensembl.
DR GO; GO:0007030; P:Golgi organization; IEA:Ensembl.
DR GO; GO:0007041; P:lysosomal transport; IEA:Ensembl.
DR CDD; cd21247; CH_SPTBN5_rpt1; 1.
DR CDD; cd00176; SPEC; 15.
DR Gene3D; 1.20.58.60; -; 21.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF435; SPECTRIN BETA CHAIN, NON-ERYTHROCYTIC 5; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00435; Spectrin; 24.
DR SMART; SM00033; CH; 2.
DR SMART; SM00150; SPEC; 27.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 21.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 42..147
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 165..270
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1319..1347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2371..2402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1895..1922
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2277..2304
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2919..2946
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1328..1347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2382..2402
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3560 AA; 400868 MW; D98076618C2EABEE CRC64;
LAGRSHSPHR RPAPGPLPQS CPTMDSAYET SHIRKLQAQH KRMQEKTFTN WINNIFQHSR
VGVKIQNLYT ELADGTHLLR LLELISGEAL PPPSRGRMRV HFLENSSRAL AFLRAKVPIP
LIGPENIVDG DQTLILGLIW VIILRFQISH ISLDGEEFGA SAALLSAKEA LLVWCQRKTA
CYANVNITDF SRSWSDGLGF SALIHAHRPD LLDYCSLRPE RPLHNLDLAF CVAEQELGIA
SLLDPEDVAA LQPDERSIMT YVSLYYHHFS RLHQEQTVQR RLAKILLQLQ ETEELRTQYQ
QLVADLRCWI AEKQAQLEAR DFPDSLPATR QLLVAFAFFR TQEKPPRLQQ RGATEALLFR
LQTALRAQDR KPFLPHEGLG PAELSQRWAG LERAEASRGQ ALLRRILQLE RLETLVRRFQ
HKAALRESFL TDAEHMLDQA AAAAPPAGLA AVEAAAQRLG MLEAGILPQG GRFQALAEIA
DVLQQGQYTG WADVASSLPP PQQLVETMEL LQKHDLLEAQ VSAHGAHVHH LALQSEELDS
SLGANVEVLQ AKAQALAQLH RSLVSLVRAR RVSLEQSLQQ AEFLNNCEEE EAWLREHRQL
VEDEALGRDL SQIRVALRKH KALESELRHH QAVCADLVRR GCDLGAPGHP TRPDPRERAE
ALQGAWQRLR AQVARRGARL QAALLLQASV LRGAPVDMLP SVLSAQVVSA LSSPKKGLRN
LGTWSEVSGH SAPPGTQKMA LLAEPDPNFD PNTILQTQDC LSQDYEGLQA LVKHRRARLE
EAVALFGFRG LCGELRSWLE NQTALLRTLQ PQAHNLEVAQ LTYENFLTAL AVGRGLWAEV
SSNAEQLKQR YPENTPKIQQ QQEELSRRWG RLEALKKAKE TQLTHTTDMC SLLHECGSTR
VQLQDLLLQL ETLELGQSED SHRALQLAQR KMLTLERSVS CLQSTARKYN PTESRSLQEQ
VETLQGLLEQ GRQRVARQAG ARAEARAQQS LLRESRQLLR WAEGIWAQLR GGEKVVDVAS
ARRLLMEHTD LLEEIQLRQE RLQQLEAQGQ PVSALDSADS RELACALRLL SQQGQGLQAA
WEQRRQRLQE GLELWRFGRD VDGFAATCAS HEAFLWLDKL GEDGGEAQSL LQWHQEFERQ
LGILGHRAEA LRARGEMLAL SQHPAAHKVR EQLQSVQVQW TRVQERSEQR RQQLLASLQL
QKWKQDVAEL VLWIEEKGLR AADEPSWEPG NILQQLRRLQ AAERELLAAC GHVEGLQQVG
RQLLSDRPHA REGVQASLQG LSGKWEGLKH KLAEHGERLQ RARQLLELLQ DAKEKMEQLE
GALRSAETGQ DLGSSRRLQR QHSQLESKSQ ALASKMAALV SQAHRGLTSQ TVMEETQKYL
QRFESLQGHV AAWRLQLQAS VEMCHFDQLS NVELTWVAEH MPGAGSSRCL NGAQSLQRKH
EELWAEVKAH QGQVQRVLGS GQSLAASGHP QAPRVLEQCQ KLEGRWAELE RACEAQAQCL
QQAVALQQCF LAASELEDWV KEKQPLVGSQ DCGADEAATV RLMEKHQALQ QELALSWSSM
EKLDQRAQML AGAGAPEQLG AVLERLREQL RVLQEQAATR GRELEGTLKL HEFLGEAEAL
QSWLATQKQA ARPAEDLGED HAHVLHLLTE FARFQRQVEL GGRRVAGCQQ LVESLRELGH
SAAPDARRKQ QDLQTAWSEL WELTQAQGHL LQDAEVTLRV HRDLLEALAQ VQEKATSLPS
EVAPDLRGLE AQLRRHEELE HELVGTGRQL QELLEAANTA QKLGPGPQAH AMRRRQQALV
RAWEALKLRA ERRRTQLERA CLLARFHRAV RDYTSWAAAV WQELQGEESS EEPSGGLLTL
SAHRQLRAEL EAREELHQRA SQLGQQALLA VGTPIKEVQE GLRALQDERE QVFQAWERKE
EKLQARHREQ LFFRKCGHLD QILTAQEVSL KTGALGSSVE EVEQLIRKHK TFQKVLTAQN
EKEAALCEQA KTLGGPQVQD RLRMVLEQRA RVRDLAESRG QALHTCLLMT GFTRAVTQAQ
DWIEERVQQL KEPVPPGDLK DKLRLQWKHQ AFEAEVQAHE EVITSVTKDG EALLAQSHPQ
AGEVSQRLQV LREHWRKLRQ AVALRGQDLE DRWNFLEFLQ RADHAEAWIQ EMEVMVNLGD
LGQDLEHCLQ LRRRLRRLPG VWAQDRVEDT RIRSVNDLSM KLENLDPEQV KTIHQRRQQL
GSRWKSFHGN LLRYQQQLEG ALEIHTLSRE LDDLTERIGE KAALLQAPDY GKDLESVQRL
IQKHQELEQE MGLLQAQVEL LEREVGRVCQ RSPGTARSLG RKQREVMASW QQLCGGAQKR
REALEASQRA QNLQAMLRHW SAWARGLRAE MEAQSAPRSP AEAQRRLEEH QELKAELESR
TDSIDLARST GQRLLAAGHP PTPDLHQALA GLDQELNSLE GAWQEHKHRL QQALELQLLL
SSVEQMESWL CTQEACPASE GLGDSLAAVE TLLQKHRVLE QGLEAQAEKI SALAAAARSL
HEGGHPEAHG ALGRCQAMLL RKEALVERAG TRRRQLEEFQ QLRTFLQDSF EVATWLREKN
SVALEEGWRD PALLRAQLWK QQSLQAELDA TVHHQQRLQM EGQRLLQEGH QASETIRERL
RELGELWDEL QANSQRKAAT LRDACKALHL RRSVEELESW LEALEVKLRA PVEDQDQPGL
DELLGAQGEL EAAVAGQARQ AQWLLGQARV LTGEGHCLTQ DVEAQARQLL PRFESLREPL
QERRAALQAR SRLLEFFRDV DEEMAWVQEK LPLATTQDCG QSLSAVRHLQ EKHQNLEREM
SSREALTQAV VVAGRQLVQA GHLAAGGVAT RVQQLESAVG CLRAEATRRR LQLQQAREAQ
QFLTELLEAE SWLEERGCDL DIEDKGQSAE ATRAFLRQLE ATRRDLEAFR TRIERLQQTA
AVLESRQNPE SARVLARMRA VREVHSGLLQ RAEGRGQGLR EQLKLHQLDR EALLLETWLA
SKVATAESQD LGQDLEAVEM LEEKFDAFRR EVQSLGQAKV QALRELAGSL ERTAPRCALQ
IQAQRSRIEA TWGRLDRAIK ARTQSLATAR EVQGFEQAAA ELQGWMQEKA ALVVRDICEH
SLSSVQTLQQ QHRRLEWHLA AVEKEVARVR TEACRLGQLH PVAWEGLCEQ LAKVEEAWAA
LEVKAQERGR QLEQAARGHA FLGRSRELLA WAQETQALAS SEELAADVVG AERLLAQHAE
LGREIEEHCL RARELQQEGQ QLADSGHFMS PEVTGCLQEL EGWLRALTEA CTLRQERCEG
NWGLQKLREQ LDWAEAWLAS REGLLLDPNC GDTVSDVEWL LCRHQDLEKL LAAQEEKFAQ
LQRKAGVEQN LPQQGPGLKS GSAGHRLTPL QQRPFGSRWP GVQLAETRDL QPASGDTQVI
TRPGCSLPST PSWCSLPAFS LQPCSSPWDG CHGTLGGSSL SLFQDKRTAA ENMAPVASLD
VRRAQYESPG HQHGRKHAFS VRLSSAVETV CAAPAEGRAE SWHRALNWGS GKSSSGLGVV
PSHCVLTWWN GPGCSLGSSP
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