ID G1ME76_AILME Unreviewed; 722 AA.
AC G1ME76;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Leucine rich repeat and sterile alpha motif containing 1 {ECO:0000313|Ensembl:ENSAMEP00000017654.2};
GN Name=LRSAM1 {ECO:0000313|Ensembl:ENSAMEP00000017654.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000017654.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000017654.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000017654.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G1ME76; -.
DR STRING; 9646.ENSAMEP00000017654; -.
DR Ensembl; ENSAMET00000018374.2; ENSAMEP00000017654.2; ENSAMEG00000016718.2.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00930000151044; -.
DR HOGENOM; CLU_022990_0_0_1; -.
DR InParanoid; G1ME76; -.
DR TreeFam; TF329645; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0045806; P:negative regulation of endocytosis; IEA:Ensembl.
DR GO; GO:2000786; P:positive regulation of autophagosome assembly; IEA:Ensembl.
DR GO; GO:1904417; P:positive regulation of xenophagy; IEA:Ensembl.
DR GO; GO:0051865; P:protein autoubiquitination; IEA:Ensembl.
DR GO; GO:0030163; P:protein catabolic process; IEA:Ensembl.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:Ensembl.
DR GO; GO:0070086; P:ubiquitin-dependent endocytosis; IEA:Ensembl.
DR GO; GO:0046755; P:viral budding; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF46; LEUCINE RICH REPEAT AND STERILE ALPHA MOTIF CONTAINING 1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 565..632
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 674..709
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT COILED 285..376
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 515..546
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 722 AA; 83514 MW; F5BA9088B6E64FF0 CRC64;
MPLFFRKRKP SEEARKRLEY QMCLAKEAGA DDILDISKCE LSEIPFGAFA TCKVLQKKVL
IVHTNHLTSL LPKSCSLLSL VTIKVLDLHD NQLSALPDDI GQLTALQVLN VERNQLTYLP
RSIGNLTQLQ TLSVKDNKLK ELPDTLGELR SLRTLDISEN EIQRLPQLLA HVRTLETLSL
DASSMVYPPQ EVCSAGTQAI QQFLCKESGL EYYPPSQYLL PVLEQDRADA SQDSPDGPTG
RVSREEVEWQ NRFSDYEKRK EQKMLEKLEF ERRLELGQRE HAQLLQQSNN QKDEILQTVK
EEQSRLEQGL SERQRHLDAE RQRLQEQLKQ TEQNISNRIQ RLLQENQRQK KSSEILKSLE
NERIRMEQLM SITQEETENL RRREIASAMQ QMLTESYKNR LIQMAYESQR QSLVQQACSS
MAEMDERFQQ ILSWQQMDQN KAISQILQES AMQKAAFEAL QVKKDLMHRQ IRNQIKLIET
ELLQLTQLEV KRKALDTEAL QEMISEQRWA LSSVLRQLLK EKARREEELR EILTELEAKS
ETKQENYWLI QYQRLLNQKP LSLKLQEEGL ERQLAALLVD LSAEHYLPLF AHHRISLDTL
SRMSPADLAK VGVSEAGLQH EILRKVQELL DAARIQPELL NPPKGEVLGA PEELPESVSP
SAPPAELELP TSECVVCLER EAQMIFLNCG HVCCCHQCCQ PLRTCPLCRR EITQRLRLYH
SS
//
