ID G1MG80_AILME Unreviewed; 79 AA.
AC G1MG80;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Centromere protein X {ECO:0000256|ARBA:ARBA00016388};
GN Name=CENPX {ECO:0000313|Ensembl:ENSAMEP00000018362.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000018362.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000018362.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000018362.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CENP-X/MHF2 family.
CC {ECO:0000256|ARBA:ARBA00009359}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G1MG80; -.
DR STRING; 9646.ENSAMEP00000018362; -.
DR Ensembl; ENSAMET00000019103.2; ENSAMEP00000018362.2; ENSAMEG00000017384.2.
DR eggNOG; ENOG502S98G; Eukaryota.
DR GeneTree; ENSGT00390000002725; -.
DR HOGENOM; CLU_175684_0_0_1; -.
DR InParanoid; G1MG80; -.
DR TreeFam; TF330764; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0071821; C:FANCM-MHF complex; IEA:Ensembl.
DR GO; GO:0043240; C:Fanconi anaemia nuclear complex; IEA:Ensembl.
DR GO; GO:0000939; C:inner kinetochore; IEA:Ensembl.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0036297; P:interstrand cross-link repair; IEA:Ensembl.
DR GO; GO:0051382; P:kinetochore assembly; IEA:InterPro.
DR GO; GO:0031297; P:replication fork processing; IEA:Ensembl.
DR GO; GO:0000712; P:resolution of meiotic recombination intermediates; IEA:Ensembl.
DR Gene3D; 1.20.5.4980; -; 1.
DR Gene3D; 6.10.130.30; -; 1.
DR InterPro; IPR018552; CENP-X.
DR InterPro; IPR009072; Histone-fold.
DR PANTHER; PTHR28680; CENTROMERE PROTEIN X; 1.
DR PANTHER; PTHR28680:SF1; CENTROMERE PROTEIN X; 1.
DR Pfam; PF09415; CENP-X; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
SQ SEQUENCE 79 AA; 8787 MW; 908D0C958147E687 CRC64;
MEGTGGGFRK DLVSKLLRLH FTDSKTKVSG DALWLMAELL TIFVVETAVR SVRQAQAEDL
ALVDVDQLEK VLPQLLLDF
//
