GenomeNet

Database: UniProt
Entry: G1MYS9_MELGA
LinkDB: G1MYS9_MELGA
Original site: G1MYS9_MELGA 
ID   G1MYS9_MELGA            Unreviewed;       837 AA.
AC   G1MYS9;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 2.
DT   22-NOV-2017, entry version 31.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=TCIRG1 {ECO:0000313|Ensembl:ENSMGAP00000004135};
OS   Meleagris gallopavo (Wild turkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Meleagridinae; Meleagris.
OX   NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000004135, ECO:0000313|Proteomes:UP000001645};
RN   [1] {ECO:0000313|Ensembl:ENSMGAP00000004135, ECO:0000313|Proteomes:UP000001645}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA   Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA   Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA   Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA   Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA   Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A.,
RA   de Jong P., Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D.,
RA   Lee M.K., Lee T., Mane S., Marcais G., Marz M., McElroy A.P.,
RA   Modise T., Nefedov M., Notredame C., Paton I.R., Payne W.S.,
RA   Pertea G., Prickett D., Puiu D., Qioa D., Raineri E., Ruffier M.,
RA   Salzberg S.L., Schatz M.C., Scheuring C., Schmidt C.J., Schroeder S.,
RA   Searle S.M., Smith E.J., Smith J., Sonstegard T.S., Stadler P.F.,
RA   Tafer H., Tu Z.J., Van Tassell C.P., Vilella A.J., Williams K.P.,
RA   Yorke J.A., Zhang L., Zhang H.B., Zhang X., Zhang Y., Reed K.M.;
RT   "Multi-platform next-generation sequencing of the domestic turkey
RT   (Meleagris gallopavo): genome assembly and analysis.";
RL   PLoS Biol. 8:E1000475-E1000475(2010).
RN   [2] {ECO:0000313|Ensembl:ENSMGAP00000004135}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMGAP00000004135}.
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DR   STRING; 9103.ENSMGAP00000004135; -.
DR   Ensembl; ENSMGAT00000004848; ENSMGAP00000004135; ENSMGAG00000004250.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   InParanoid; G1MYS9; -.
DR   OrthoDB; EOG091G01BI; -.
DR   TreeFam; TF300346; -.
DR   Proteomes; UP000001645; Chromosome 5.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0016236; P:macroautophagy; IEA:Ensembl.
DR   GO; GO:0007039; P:protein catabolic process in the vacuole; IEA:Ensembl.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001645};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    399    431       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    451    469       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    547    566       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    578    598       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    640    664       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    773    797       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    128       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   837 AA;  94498 MW;  6F57E21C70D061B6 CRC64;
     MGSLFRSEEV CLAQLFLHSA SAYSCVSELG ERGLLEFRDL NPHVSAFQRR FVGEVRRCEE
     MEKTFTFLQQ ELQGAGRVLE PCTENPPAPV AREALRVQEQ SEQLARELRE VSRNRAALRG
     RLQDLRQYLH VLREGQHLTS MPGPPGSPSS SRVFSEHEPL LDPSVQHHLD RKINFVTGVI
     HPWRVSAFER LLWRACRGYL VASFVEMPEP LEDPNTGENV TWVIFLISYW GEQIGQKIHK
     ISDCFHCHVY PYPESEASRA DTLNGLVSQI QDLSVVLEET EQYLAQVLDK VVLALPSWRV
     QVQKMKAIYL VLNQCSLDVT EKCLIAEVWC PVQDLTQVQE ALRQGSYKSG SSVECFVQRI
     PTLESPPTLI XXXXXXXXXX XXXXXXXXXS YQEVNPAPYA IITFPFIFAI MFGDVGHGLL
     MFLFALWMVL FENSPSLQQG SNEIWQMFFK GRYLILLMGA FSIYTGFIYN ECFSKATVIF
     PSAWSVATMA NHSSWSSAYL ATHQSLTLDP NVTGVFQGPY PFGIDPIWSL ATNHLNFLNS
     FKMKMSVVLG IVHMGFGVLL GIFNHVHFRQ WHRLVLELLP EVVFLLALFG YLVFLIFYKW
     VKFSAADSQV APSILIHFID MFLFTSNADN LPLYQGQVPV QMVLVVLALV SVPVLLLGTP
     LYLYNQQHRR RANSIPPTAT VEQEPLLEGQ EAGNSVNAAK EDVESGGYGP DAEHMDFSEV
     FMHQAIHTIE YCLGCISNTA SYLRLWALSL AHAQLSEVLW TMVMHNGFVG LSYIGGVVLV
     PVFAAFAVLT MAILLVMEGL SAFLHALRLH WVEFQNKFYV GAGYKLCPFT FAPDPWE
//
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