ID G1MYS9_MELGA Unreviewed; 789 AA.
AC G1MYS9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000004135.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000004135.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000004135.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR AlphaFoldDB; G1MYS9; -.
DR Ensembl; ENSMGAT00000004848.3; ENSMGAP00000004135.3; ENSMGAG00000004250.3.
DR GeneTree; ENSGT00950000182881; -.
DR HOGENOM; CLU_005230_0_0_1; -.
DR InParanoid; G1MYS9; -.
DR TreeFam; TF300346; -.
DR Proteomes; UP000001645; Chromosome 5.
DR Bgee; ENSMGAG00000004250; Expressed in liver and 17 other cell types or tissues.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF21; V-TYPE PROTON ATPASE 116 KDA SUBUNIT A 3; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 3.
DR PIRSF; PIRSF001293; ATP6V0A1; 3.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 408..432
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 453..471
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 594..616
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 725..749
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT COILED 124..158
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 789 AA; 88749 MW; DFED373F14A8E310 CRC64;
MAGLFLGEEE VRSPALPTEH RLQGVPNQAA MGSLFRSEEV CLAQLFLHSA SAYSCVSELG
ERGLLEFRDL NPHVSAFQRR FVGEVRRCEE MEKTFTFLQQ ELQGAGRVLE PCTENPPAPV
AREALRVQEQ SEQLARELRE VSRNRAALRG RLQDLRQYLH VLREGQHLTS MPGPPGSPSS
SRVFSEHEPL LDPSVQHHLD RKINFVTGVI HPWRVSAFER LLWRACRGYL VASFVEMPEP
LEDPNTGENV TWVIFLISYW GEQIGQKIHK ISDCFHCHVY PYPESEASRA DTLNGLVSQI
QDLSVVLEET EQYLAQCSLD VTEKCLIAEV WCPVQDLTQV QEALRQGSYK SGSSVECFVQ
RIPTLESPPT LIRTNKFTAG FQSIVDAYGV ASYQEVNPAP YAIITFPFIF AIMFGDVGHG
LLMFLFALWM VLFENSPSLQ QGSNEIWQMF FKGRYLILLM GAFSIYTGFI YNECFSKATV
IFPSAWSVAT MANHSSWSSA YLATHQSLTL DPNVTGVFQG PYPFGIDPIW SLATNHLNFL
NSFNHVHFRQ WHRLVLELLP EVAPSILIHF IDMFLFTSNA DNLPLYQGQV PVQMVLVVLA
LVSVPVLLLG TPLYLYNQQH RRRANSIPPT ATVEQEPLLE GQEAGNSVNA AKEDVESGGY
GPDAEHMDFS EVFMHQAIHT IEYCLGCISN TASYLRLWAL SLAHAQLSEV LWTMVMHNGF
VGLSYIGGVV LVPVFAAFAV LTMAILLVME GLSAFLHALR LHWVEFQNKF YVGAGYKLCP
FTFAPDPWE
//
