ID G1N7R4_MELGA Unreviewed; 3069 AA.
AC G1N7R4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=WDFY family member 4 {ECO:0000313|Ensembl:ENSMGAP00000008273.3};
GN Name=WDFY4 {ECO:0000313|Ensembl:ENSMGAP00000008273.3};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000008273.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000008273.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000008273.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSMGAT00000009065.3; ENSMGAP00000008273.3; ENSMGAG00000008076.3.
DR GeneTree; ENSGT00940000155684; -.
DR HOGENOM; CLU_000175_5_2_1; -.
DR InParanoid; G1N7R4; -.
DR TreeFam; TF313658; -.
DR Proteomes; UP000001645; Chromosome 8.
DR Bgee; ENSMGAG00000008076; Expressed in bursa of Fabricius and 7 other cell types or tissues.
DR GO; GO:0019882; P:antigen processing and presentation; IEA:Ensembl.
DR GO; GO:0036037; P:CD8-positive, alpha-beta T cell activation; IEA:Ensembl.
DR GO; GO:0098586; P:cellular response to virus; IEA:Ensembl.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR46108; BLUE CHEESE; 1.
DR PANTHER; PTHR46108:SF3; WD REPEAT- AND FYVE DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 2389..2514
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2494..2788
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 2945..2986
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 14..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1941..1962
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1945..1962
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3069 AA; 344369 MW; 2DA9255732798F59 CRC64;
MDKAAELVWQ LEDSSCEAGQ QEQSPDHVDK SEVPEQPAHR KDNLPQSHTL QWETLCRQFV
EYEQAAPFLI PEEQQRRLLD FLPFFLKAWE QSAGVIVFPS VQLLASEVSK LLTKEIKRTL
NGKSAEEARL ALEHLLQQKG EVEDGHLLLK SVYLLSRTDL KTMWNIIGSG LPAALLQCLY
LFFTFPLKRN TDGETNEDET QKMLVEIMLN MYREEQGVEE LLAADKLQSL IIAAASLWDQ
CSHPWKVPTG LVLRTISKAQ TKNSILYLQA VDCIKIAVQN LFKLADTLPA CDVCEAVSIV
LCFVKDSYPI SSALLTEFES NDGYQLLLKV LLRCEGLQQN EGDPYLNEIL DMLTCLTTCG
KTELKVSGNI IHPQLPQFDY EWTRSSGMTV KNLQAFQVLQ SIFQKSNDQH LCGTVLGAIG
TIWAWDTVNF FLLEWTLQPI NQFIDIIHFK PHPVQVQFFR LVESIVLDLS YIPHEILKKV
QYLIKENVVP FCTLTALQCL LSITKKDLLF SDIFRDSGLL GLLLAVLRKQ AKILRKSAGT
SLPGVEEGTD KELNAVMLKM VAALTVGCVR NSVVLKDYGM VPYIKIFLDD ECYRGATLSI
LEQLSVINYE EYMSIVIGAL CSSTQGELHL KLDLLKSLLR ILNSPKSHSA FRTCSGFNGL
LSLLSDMEGA LQDPPYGLWA AVGQNCILEL VFYTLQGITA ALHLDPVNSN FFQRNGLFEK
MAEDLGSLGC FWTHTEWHIP LSLEKTRTFT EFLDAAFCSS EPFPAWLKNC IWILSFLDHM
IKGTLHLENY FKEINSEMGE ASREDQEGTQ AHGEHPVFSE RPVILHVFSC RWEMRDCVIV
NPGAVCVMVR LLPKLYREGH SQISQEIQCA VADHIQSLVK SEKSRQVMCG SGLLSTIITS
CQDAFRNESH PLHLPLTRVF EKLASQSIEP DVLRQFLCLG SSLSVPSPPN TKRTEVLSCQ
ESDSSKASLN EEEVVADSKT ALQTAVPLSN SSWASKRSAL ALQTAMSLIS MTSPRNLQLH
SSTALAPSFV EFDMSMEGYG CLYLPTLATV LGPSAEQSVS GGIGMCSRMF PPSSGLTLSC
WFLVSKFGMV HNSHPLRFLT IVRHMSRTEQ EFVCFSVSFS PQDCSLVIST EEVEFQPLDI
MEPEGEVQNI SPFPEEVQFG CGKLLVTGQW HHLTVTVAKE AKKNCVVSAF INGQMLGSAK
MRYFQMLPGN CISMDPSSFI DVYGYIATPR VWKQKSSLIW RLGPTYLFEE AISVETIEVI
NKLGPQYCSN FQAVQLQGEN QYGEQNPAQL VAEEKISFGI NAVCSSFCTI QDIRSSYNEV
DGRLVAKEIG INSRDGSTPI LLAKNIAGHL SGSLRTIGSV AVGQYGVRVF KSSPAATSLN
FIGGPSILLG LIAMASDDHT MYAAVKVLNS ILNSSPMSEK LMRHIGGYQL LTYLLKRKTQ
LLNNRILQLM FSLVGTAELG FGSSVIKNYN ASQYILCNFE LWMKAPENLD LTLFAHLVEI
LQCSRDGCQN AEVAHRVQMV PKLIFLFSDP EISNSRITVV CTILSHLLQG YFNTKDVLRI
GLFLVYTLKP SSVDENQLCL DSSAEMPSEA LSQTSGKTIW LRNQLLKMLL DVICSAKIHL
SSEVQEEAFL ALGPDWFLLF TQSYLHSSTV VLGIKLLLYF LHNRLLLNKF KEGIVAGRWL
ENSTAGLSIL MDNLKTHPLV PDSGSILIFG FSVLQKCLTD HVHIPEIYLL VAGLFLATPY
SEPPEAAKGD LDSMLQWILQ QHVTENVLKN GLCAEAAVLL LEMVRVIVDK PIAGAEVSWE
IVYPGNVIQF LCLIYHSYTE DPVWHCPDFL KTLAVVAFHS GPPKGGKTSE GLLTPDGPAI
AEGKGCTDSS LPRLSHPAKK QVWDFMHILL MDSLLNTPAN KQEHPLELLL EASPEDATSE
QKKHFQTKVL LSAMDVFDVT SQGEGKTRPR GNSDLHSSSE STASASMMNV TYVAQKLIEK
MNSKMFAADF KQILLFIAKQ ITRVLEAPVS QKDVFLSTMY SCLNRAILYC LSRPQQSLPE
QFNVLNALSV LQEQWDIIFA TYNSSNNFII CLMHCLCQLN SGSYPEGFGV DAKPKLASYH
QIFLAPSEEE RDTPNWSDLQ GKTEILRTIE IIWKQLISQR RQALEDIYNM DLSVKGSDRE
RDIKITEITP LWEEMMAKAW QNFLASEKRV LQNKSVLGLS QSKHSSWSES LSSAMRLMPS
RNTKEMTCKS EGFVSCMERY RRTGQELYAS LYRNHVQVLQ CGYSKAAKDW MILEEQLFNR
QGPWGVASQS LNPRWILDCY EGPSRMRRRI RQASNQATMM RMKSEVESFY RKCTNPVAIL
MLNGAEKEGD EKGLDCNQLT FFPALHESFH SEDFLELCVE RQIILQEFAE NEKVTFKCSV
AVVQGHTALE GVLLFGREHF YICECFVLSP LEEVCCTQHC LSSISDPFIF NLCHKEHVVG
DQRCSRYSYH DIKEIRLMRF LLQEIALEIF FKNGYSRFLV FHDCDRKKIF KREISNFDYL
MYLNTLAGRS YNDYMQYPVF PWVLADYHSQ TLNLSNPHTF RDLSKPMGAQ TVERRQKFIQ
RYKEVEKSEG DLSAQCHYCT HYSSAIIVAS YLVRLEPFTQ TFCSLQGGSF DVADRMFHSV
KSTWESASRD NMSDVRELIP EFFYLPEFLT NANHFELGCM QDGTVLGDVQ LPPWADGDPH
KFILLHRQAL ESDYVSAHLH RWIDLIFGHK QQGSAAVEAV NTYHPYFYGD KMNLNNIKDP
LIKSTILGFI SNFGQIPKQL FTKPHPPRNV QSKSSSGREA VLSFQSNGIL PPFISSLQNL
KLSPVTVKEL NTFFVLSEYP KGAVGHIVHT EKGILAVEKN KVLIPPLWNK TFCWGFDDFT
CCFGNYGSEK NMTTSECMAD WGKCLCAVCP SATTIITSGT SSVVCVWELS LVKDKVKRLS
LRQALYGHSQ SVTCLAASVT YSIIVSGSDD RTCIIWDLNH LTYITQLPAH GASLSSVAIN
NSTGDIASCA GSYLHLWTVN GQPLVSVNTT CSPKSCIACC CFAEVMDWDT RSIVITGSTD
GVVRVSDQG
//
