ID G1NE59_MELGA Unreviewed; 396 AA.
AC G1NE59;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Chimerin 2 {ECO:0000313|Ensembl:ENSMGAP00000011187.2};
GN Name=CHN2 {ECO:0000313|Ensembl:ENSMGAP00000011187.2};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000011187.2, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000011187.2, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000011187.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_010711138.1; XM_010712836.2.
DR AlphaFoldDB; G1NE59; -.
DR Ensembl; ENSMGAT00000012057.2; ENSMGAP00000011187.2; ENSMGAG00000010748.2.
DR GeneID; 100541305; -.
DR KEGG; mgp:100541305; -.
DR CTD; 1124; -.
DR GeneTree; ENSGT01030000234635; -.
DR HOGENOM; CLU_015883_0_0_1; -.
DR InParanoid; G1NE59; -.
DR TreeFam; TF342052; -.
DR Proteomes; UP000001645; Chromosome 6.
DR Bgee; ENSMGAG00000010748; Expressed in bursa of Fabricius and 17 other cell types or tissues.
DR GO; GO:0045202; C:synapse; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04372; RhoGAP_chimaerin; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR020454; DAG/PE-bd.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR037860; RhoGAP_chimaerin.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR46075:SF4; BETA-CHIMAERIN; 1.
DR PANTHER; PTHR46075; CHIMERIN FAMILY MEMBER; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR PRINTS; PR00008; DAGPEDOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 142..192
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 205..396
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
SQ SEQUENCE 396 AA; 44947 MW; 4C22BB9AB6FC5A9E CRC64;
MQKLLPSHKP AHSSHMPEVS AEWAAAASNL LSNIRSSWTN CAVLTAASLP SAGEDREKIW
DPSAMFSEDL WLENEKSCAV VHKSKRGRKR QELLAVALGV KVGVKGALLW QPLKLFAYSQ
ITSLVRRAAL TQNDNHFNYE KAHNFKVHTF RGPHWCEYCA NFMWGLIAQG VRCSDCGLNV
HKQCSKYVPN DCQPDLKRIK RVYCCDLTTL VKAHNTQRPM VVDSCIREIE ARGLKSEGLY
RVSGFTEHIE DVKMAFDRDG DKADISASIY PDINIIAGAL KLYFRDLPIP VITYDTYSKF
IEAAKISNPD ERLEAIHEVL MLLPAAHYET LRYLMIHLKK VTLHEKENFM NAENLGIVFG
PTLMRPPEDS TLATLNDMRY QKLIVQILIE NEDVLF
//
