ID G1NIE1_MELGA Unreviewed; 2167 AA.
AC G1NIE1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Calcium voltage-gated channel subunit alpha1 I {ECO:0000313|Ensembl:ENSMGAP00000013029.3};
GN Name=CACNA1I {ECO:0000313|Ensembl:ENSMGAP00000013029.3};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000013029.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000013029.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000013029.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSMGAT00000013931.3; ENSMGAP00000013029.3; ENSMGAG00000012353.3.
DR GeneTree; ENSGT00940000158594; -.
DR HOGENOM; CLU_000540_2_0_1; -.
DR TreeFam; TF313555; -.
DR Proteomes; UP000001645; Chromosome 1.
DR Bgee; ENSMGAG00000012353; Expressed in brain.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR005445; VDCC_T_a1.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF209; VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR01629; TVDCCALPHA1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 359..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 584..602
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 622..640
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 705..727
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 783..805
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1095..1113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1133..1155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1170..1198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1233..1252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1332..1355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1411..1428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1448..1467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1546..1565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1632..1654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 70..395
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 583..811
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1093..1365
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1411..1664
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 815..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 860..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 937..962
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1685..1709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1939..1966
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1987..2100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2126..2167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1364..1391
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 534..560
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..834
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 943..962
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2021..2035
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2050..2074
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2167 AA; 243096 MW; 4F4BDF8DD7F598F1 CRC64;
MAECIPKPPS SWPMEQQMPL EQPPSSPELG EDEEVTSPPD PDVPYPDLAP VVFFCLKQTT
SPRSWCIKMC VSMMVILLNC VTLGMYQPCE DMDCLSDRCK ILQVFDDFIF IFFAMEMVLK
MVALGIFGKK CYLGDTWNRL DFFIVMAGMV EYSLDLQNIN LSAIRTVRVL RPLKAINRVP
SMRILVNLLL DTLPMLGNVL LLCFFVFFIF GIIGVQLWAG LLRNRCFMEE NFTIQGDIVL
PPYYQPEEDD EMPFICSLSG DNGIMGCHEI PPLKERGHEC CLDKDDYYYY NSVRQEFNVS
GMCVNWNQYY NVCRTGNANP HKGAINFDNI GYAWIVIFQV ITLEGWVEIM YYVMDAHSFY
NFIYFILLII VGSFFMINLC LVVIATQFSE TKQREHQLMQ EQRARYLSSS TVASYMEPGD
CYEEIFQYVC HIMRKAKRRT LGLYNSIQSR RQGHVEPSDA QRGANRKKHR HYRICQQHNP
LDCPPQGLVQ PIAVTATSDL TNCPRCHREE HDTSRRLSVL DSADSDQEGG GDSEAEGEGC
RGDQSASALE KEEEEVEEGG RMKLCSDMWR EVRVKLRGIV DSKYFNRGIM IAILVNTISM
GIEHHEQPEE LTNILEISNV VFTSMFALEM ILKLAAFGLF DYLRNPYNIF DSIIVIISIW
EIIGQSDGGL SVLRTFRLLR VLKLVRFMPA LRRQLVVLMK TMDNVATFCM LLMLFIFIFS
ILGMHIFGCK FSLRTDTGDT VPDRKNFDSL LWAIVTVFQI LTQEDWNVVL YNGMASTSPW
ASLYFVALMT FGNYVLFNLL VAILVEGFQA EGDANRSYSE EDQSSSNVEE LDQFQEVQEG
SDPKLCAISV TPNGHLDPSL PSSNAPVAAG GVSNSSRNSL QPDQIRVAIG SRKSSVMSLG
RMTYDQRSLS SSRSSHYGAW GRSGAWGSRR SSWNSLARGH SLKHKPPSAE HESLLSGERH
RTGDRELDGT ERVFHHRRTL SLDNKGSCDL LELASIPSGH KGTCRPGTTS GGSEHQDCNG
KMPSIAKEIF PKMNNRKERG EDDEEIDYSL CFRIRKMMEV YKPDWCELRE DWSIYLFSPQ
NRFRLLCQTI IAHKLFDYVV LAFIFLNCIT IALERPQIEH RSTERIFLTV SNYIFTAIFV
AEMTLKVVSL GLYFGDQAYL RSSWNVLDGF LVFVSLIDIV VSVASAGGAK ILGVLRVLRL
LRTLRPLRVI SRAPGLKLVV ETLISSLKPI GNIVLICCAF FIIFGILGVQ LFKGKFYHCL
GVDIRNITNR SDCVAANYKW VHHKYNFDNL GQALMSLFVL ASKDGWVNIM YNGLDAVAVD
QQPVTNNNPW MLLYFISFLL IVSFFVLNMF VGVVVENFHK CRQHQEAEEA RRREEKRLRR
LEKKRRKAQR LPYYATYCPI RLLIHSVCTS HYLDIFITFI ICLNVVTMSL EHYNQPVSLE
TALKYCNYLF TTVFVLEAVL KLVAFGLRRF FKDRWNQLDL AIVLLSVMGI TLEEIEINAA
LPINPTIIRI MRVLRIARVL KLLKMATGMR ALLDTVVQAL PQVGNLGLLF MLLFFIYAAL
GVELFGKLVC NDENPCEGMS RHATFENFGM AFLTLFQVST GDNWNGIMKD TLRDCSHDDR
SCLSNLQFIS PLYFVSFVLT AQFVLINVVV AVLMKHLDDS NKEAQEDAEM DAEIELEFAH
GLCSRKSGSS KSRQGKGAGT GGGGGRTEPE GRMCTRCYSP AQENLWLDSV SLIIKDSFDG
ELMIIDNLSG SVFHHYSSPA MCEKCNHDKQ EVQLAEMEAL SLNSDKSSSI LLGDDLLCDL
PLNFTRFCLY FFFFQDGQDS PDSTEAGDLG ECLLSISSTD GSTNPDSYLC EIEKTPFNSV
QSWLKHEGTK VPPSPFSPGT SCPLLPVPAE FFHPAISTAQ TGPEKVSCAH NLPKISLQGS
WASLRSPSVN CSLLHQAPES DTSLDSRSSS SAGSLQTTLE DSLNLSDSPQ CTLDLPVALC
PMPAAGDQRP LAAPLSPTSR RRGLRGRGLF TLRSIRRHQR SHSSGGSTSP GCTHHDSMDP
SDEEGAGSSL RGGGNNSEPS ETLSSLSLTS LFSPPPPGLT LGKKCSSTSS LHASPSLRRP
AAHHTKPFYT VDPKGFLSMP SWVTDFCKDT PPPVQGAEPD GPSRLGTGEC SSPLPSELGD
GVSKRNR
//
