ID G1NM99_MELGA Unreviewed; 1460 AA.
AC G1NM99;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=von Willebrand factor {ECO:0000256|ARBA:ARBA00016619};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000014699.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000014699.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000014699.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Multimeric. Interacts with F8.
CC {ECO:0000256|ARBA:ARBA00025858}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR Ensembl; ENSMGAT00000015637.3; ENSMGAP00000014699.3; ENSMGAG00000013898.3.
DR GeneTree; ENSGT00940000155810; -.
DR HOGENOM; CLU_000076_5_0_1; -.
DR InParanoid; G1NM99; -.
DR TreeFam; TF300299; -.
DR Proteomes; UP000001645; Chromosome 1.
DR Bgee; ENSMGAG00000013898; Expressed in pectoralis major and 16 other cell types or tissues.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR CDD; cd19941; TIL; 3.
DR CDD; cd01450; vWFA_subfamily_ECM; 3.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 3.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR032361; VWA_N2.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR PANTHER; PTHR11339:SF361; VON WILLEBRAND FACTOR; 1.
DR Pfam; PF08742; C8; 2.
DR Pfam; PF01826; TIL; 2.
DR Pfam; PF00092; VWA; 3.
DR Pfam; PF16164; VWA_N2; 1.
DR Pfam; PF00094; VWD; 1.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00832; C8; 2.
DR SMART; SM00327; VWA; 3.
DR SMART; SM00215; VWC_out; 1.
DR SMART; SM00216; VWD; 1.
DR SUPFAM; SSF57567; Serine protease inhibitors; 3.
DR SUPFAM; SSF53300; vWA-like; 3.
DR PROSITE; PS50234; VWFA; 3.
DR PROSITE; PS51233; VWFD; 1.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1460
FT /note="von Willebrand factor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5033063902"
FT DOMAIN 409..576
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 814..989
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1031..1211
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1220..1356
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 1460 AA; 163377 MW; BF43E2EDE0DA6E5B CRC64;
MKECLQMIFQ ILMIFIPCLD ATYVHCTPMC PKARGQFSTG MIFKGHFQHK QFYDSYCSCL
CRTFXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXLF FFSLKATDFM LSHHFSLFFL
AKYAEESCSI LISSVFEPCH HEVSPTPYVK NCHFDVCSCF SGKDCLCSSI TNYATACARK
NVVVQWRAPD FCPMTCPEGQ IYQQCGTLCN QTCRSLSFPD ENCDEFCMEG CYCPPGHYLD
ENEECVLKSR CSCYYDGEIF QPEDIFSDHY TMCYCEDGFM HCSKSRAPGA LLPDVFADEK
PSARIKRSLT CRSPMVTFIC PENNPRAEGL ECAKTCQNFD LECISHGCVS GCLCPKGMVR
HENKCVAPDR CPCFHNGREY AKGETVTKDC NTCVCHGRKW ECTKNICDGT CTVIGTAHYL
TFDGMKYKFP GECQYVLVQD FCKNNSGTFR ILISNEGCSF TGEKCTKRVI ILYKGGEIEL
LNGNVNIKVS PKDSRDLEVM KSGRYYIILL SKSITVTWDL AMGVSVILKA DFNDRVCGLC
GNFDGIQNND LTSSNEHLEV DPVDFGNSWK VNTYCADVKK FNWEQALVSP LCNDNVLKQV
MVETSCNILS GGLFEECKKL VNPEPYIDIC MYDTCACESI GDCACFCDAI AAYAHVCAQK
GVIVHWRSRD LCPQSCEDLN KQELDNQCEW RYNSCGPACP ITCQHAQPLK CPLQCVEGCH
VHCPAGKILD ELSLDCVSPE DCPVCAVGDV KIPHGRRVVL SRDHPQHCQS CLCEGKNLSC
VPCEPVKEIL TLTPAPEEDR ELAPSEYSCS KMMDLAFLVD GSNKLSEEDF EQLKTFIIGM
MNKLHISQKK IRVSILVYRA GPTIYLGLKD IKTQSQMKKI VQSIKYTGDE VASVAEVLKY
IVFQVFGKAE RTNAAQIAML FLASKSPGKV RTIIPALKNK KITVIPVGIG PYVNVEQIRF
IEKQLHTRAF QMNNVLELMD NRDLLIDYLC DLGPAESSPV PTPTMSNDVF TQRVLTVPPH
FTENPTTKSL DIAFVVEGSD NVGQENFNII KKFLEKVLIE MNIGQENIHV TVMQYSDTIT
LEYSFREIQS KESIIEKVRS IPYQGGKATN TGHALDYISK HTFTSANGGR QNVPHLVYMV
SSNPSTDVIT RHPMSINVIP IGISPSANVQ ELRMISQPNR PIILQSYSTL IEEAPELVLQ
SCCSHKAWTE IPELCNKPMD VMFLLDGSPS IGVSEFEEMK NFVQAFIESA DISNTSVHVS
VLQYARENNL EISLNKPQET ENLIKMVHSI KQREQGPTRL GKAIDFVVQN ALSESYGGRP
GASKVIIVIV SGKSEDTMET AALIARMNSK SHFTDIIFKQ SCCFFNKMFL VXXXXXXXXX
XXXXXXXXXX XXXXXXXXXX XXXXXCFIGM LFLNDSDFSA YSTGSCNVLD IPGDCSFKLL
RSLNTTIPWD PQELNLLGAQ
//
