ID G1NPV2_MELGA Unreviewed; 1034 AA.
AC G1NPV2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Ion transport domain-containing protein {ECO:0000259|Pfam:PF00520};
GN Name=NALCN {ECO:0000313|Ensembl:ENSMGAP00000015779.3};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000015779.3, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000015779.3, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000015779.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G1NPV2; -.
DR Ensembl; ENSMGAT00000016740.3; ENSMGAP00000015779.3; ENSMGAG00000014888.3.
DR GeneTree; ENSGT00940000156023; -.
DR HOGENOM; CLU_000984_1_0_1; -.
DR InParanoid; G1NPV2; -.
DR TreeFam; TF312843; -.
DR Proteomes; UP000001645; Chromosome 1.
DR Bgee; ENSMGAG00000014888; Expressed in brain and 7 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR028823; NALCN.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR46141:SF1; SODIUM LEAK CHANNEL NALCN; 1.
DR PANTHER; PTHR46141; SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN; 1.
DR Pfam; PF00520; Ion_trans; 2.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 144..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 280..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 474..494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 500..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 539..557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 599..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 686..710
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 150..426
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 472..720
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 25..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 874..924
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 874..914
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1034 AA; 118878 MW; D210097C49786E91 CRC64;
MLSGSFEGQP AKERSILSVQ HHIRQERRSL RHGSNSQRIS RGKSLETLTQ DHSNTVRYRN
AQREDSEIKM IQEKKEQAEM KRKVQEEELR ENHPYFDKPL FIVGREHRFR NFCRVVVRAR
FNASKTDPVT GAVKNTKYHQ LYDLLGLVTY LDWVMIIVTI CSCISMMFES PFRRVMHAPT
LQIAEYVFVI FMSIELNLKI MADGLFFTPT AVIRDFGGVM DIFIYLVSLI FLCWMPQNVP
AKSGAQLLMV LRCLRPLRIF KLVPQMRKVV RELFSGFKEI FLVSILLLTL MLVFASFGVQ
LFAGKLAKCN DPHIISREDC HGIFRINVSV SKNLNLKLRP GEKKPGFWVP RVWANPRNFN
FDNVGNAMLA LFEVLSLKGW VEVRDVIIHR VGPIHGIYIH VFVFLGCMIG LTLFVGVVIA
NFNENKGTAL LTVDQRRWED LKSRLKIAQP LHLPPRPDND GFRAKMYDIT QHPFFKRTIA
VLVLAQSVLL SVKWDAADPV TVPLATMSVV FTFIFVLEVT MKIIAMSPSG FWQSRRNRYD
LLVTSLGVIW VILHFALLNA YTYMMGACVI VFRFFSICGK HVTLKMLLLT VVVSMYKSFF
IIVGMFLLLL CYAFAGVVLF GTVKYGENIN RHANFSSAGK AITVLFRIVT GEDWNKIMHD
CMVQPPFCTP DNSTYWKTDC GNYAGALMYF CSFYVIIAYI MLNLLVAIIV ENFSLFYSTE
EDQLLSYNDL RHFQIIWNMV DDKREGVIPT FRVKFLLRLL RGRLEVDLDK DKLLFKHMCY
EMERLHNGGD VTFHDVLSML SYRSVDIRKS LQLEELLARE QLEYTIEEEV AKQTIRMWLK
KCLKRIRAKQ QQSCSIIHSL RESQQQELSR FLNPPSIETT QPSEDMNAIN QDNSAQPETS
SQQQLLSPTL SDRGGYRQDT ADAGKPQWKI RPRCLPSCDA NEEFRVHFLS SYHGHRNLEC
SLVSFLFNFI APKPRSHPGS SVNLRSGGCL TVKSIGCKMN PMSDAASCGS EVKKWWTRQL
TVESDESGED LLDI
//
