ID G1NU88_MYOLU Unreviewed; 714 AA.
AC G1NU88;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=ERCC excision repair 6 like 2 {ECO:0000313|Ensembl:ENSMLUP00000000774.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000000774.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000000774.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000000774.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC {ECO:0000256|ARBA:ARBA00007025}.
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DR EMBL; AAPE02043278; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1NU88; -.
DR STRING; 59463.ENSMLUP00000000774; -.
DR Ensembl; ENSMLUT00000000846.2; ENSMLUP00000000774.2; ENSMLUG00000000845.2.
DR eggNOG; KOG0387; Eukaryota.
DR GeneTree; ENSGT00940000161328; -.
DR HOGENOM; CLU_000315_17_10_1; -.
DR InParanoid; G1NU88; -.
DR OMA; DGVIWPY; -.
DR TreeFam; TF351516; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd18005; DEXHc_ERCC6L2; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45629:SF7; DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED; 1.
DR PANTHER; PTHR45629; SNF2/RAD54 FAMILY MEMBER; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 147..333
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 525..675
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 714 AA; 81668 MW; 01D68C728EC27E9E CRC64;
CPPGFQAPPP GQMDPSAPKP RVETASKDIW HPGERCLVPS PDNEKLCEAS IKSIIVDENG
KSFAIILYSD FQERKVPLKR LQEVKSVKDC SRNFIFDDED LEKPYFPDRK FPSSAVAFQL
SEDGDSIPYT INRYLRDYQR EGAQFLYGHF IQGRGCILGD DMGLGKTVQV ISFLAAILHK
KGTREDIENN MPEFLLRSLK KEPPSSIARK MFLIVAPLSV LYNWRDELDT WGYFRVTILH
GNKKDNELIR IKQRKCEIAL TTYETLRLCL EELNSLEWSA VIVDEAHRIK NPKARVTEVM
KALKCNVRIG LTGTILQNNM KELWCVMDCY LVCKLLASGL LLSLQTSDLL YFLERHTATK
RELATGRKAM QRLAKKMSGW FLRRTKTLIK DQLPKKEDRM VYCSLTDFQK AVYQTVLETE
DVTLILRSSE PCTCSSGRKR RNCCYKTNSH GETVKTLYFS YLAVLQKVAN HVSLLQAAST
SKQQETLIRR ICDQVFSRFP DFVQKSKDAA FETLSDPKYS GKMKVLQQLL NHCRKNKDKV
LLFSFSTKLL DVLQQYCMAS GLDYRRLDGS TKSEERIKIV KEFNSTQDVN ICLVSTMAGG
LGLNFVGANV VVLFDPTWNP ANDLQAIDRA YRIGQCRDVK VFRLISLGTV EEIMYLRQVY
KQQLQCVVVG SENAKRYFEA VQGSKEHRGE LFGLYNIFKL RPQGSCLTKD ILEV
//