ID G1NUA7_MYOLU Unreviewed; 3100 AA.
AC G1NUA7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Dynein axonemal heavy chain 12 {ECO:0000313|Ensembl:ENSMLUP00000000794.2};
GN Name=DNAH12 {ECO:0000313|Ensembl:ENSMLUP00000000794.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000000794.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000000794.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000000794.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; AAPE02022424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02022425; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02022426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02022427; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02022428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02022429; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02022430; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02022431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02022432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02022433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSMLUT00000000867.2; ENSMLUP00000000794.2; ENSMLUG00000000864.2.
DR GeneTree; ENSGT00940000154280; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 1246..1385
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1892..2040
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 601..664
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3100 AA; 357829 MW; 27EACF4271CD8CFA CRC64;
MSDPNKAAIA AEKEALNLKL PPIVHPPENI GVDTPTQSKL LKYRRSKEQR KTINQLVIEG
AKKKLDKTLS KRTPLSPEPD DPPIMTSEIK KKGLNYIYMK QCVESSPIVP IQQEWLDHML
MLVPESLKQG KKREELLQSL ISEVSSDFEK STKRYLVKSV LMKPPVNWLE DDGGPLPEFP
VGLDYSNPWH CSYVQARNQI LSNLHIVHPI MKMLLDLGYK TFANTLLLDL TGIRNRAKGP
IDCESLKNDL SIQARKAEEK IMNTWYTKVI NLFTKKEALE GIKPEKLDSF YNCVSTLMSN
QIKDLLKRTI EGFVKLFDQG DERGLPIFKM ELTIDDEKME FYPTFQDLED VVFGLVERIA
EALQNVQSVP SWLSAASPPV NLDTELPEHM LQWALDVLKV EIHRNLEGAR QHYETYVEKY
NWLLDGTAVQ LIETFQAEDH TFDEYTEFIE KFFNLASEIM LLPQWVHFPM VRLDCEDLKT
GLTKKARAFA NKLLNDIATK HRNENECICS EFEAIKEHAL KIPETTEEMM DLIAYVEKAR
TIRMQDLISR IQESKRRMNY FLDVFIFPQE ELALNSAVLL WPWKIYPIFD ENDEIIEVAK
RKKENELIAK REKLILELEK ESRRMEEFAE FAELDRMQQY VTDVRQLQKR IQESEEAVQF
INKEEELFKW EVTKYPELDK LKVNIEPYQK FFNLVLKWQR TEKRWMDGGF LDLNGESMEA
DVDEFSREIF KTLKFFQMKL KKELQEKRKL AKRRSLGEER VEEEPKENPT INTRMRARHW
KQMSEIVGYD LTPDSGTTLR KVLKLNLTQY LEQFEVISAG ASKEFSLEKA MHTMMGTWDD
IAFHVSLYRE TGVCILSSVD EIQALLDDQI IKTQTMRGSP FIKPFEKEIK AWEDRLIRIQ
ETIDEWLKVQ AQWLYLEPIF CSEDIMQQMP EEGRQFQTVD RHWRDVMKFC AKDPKVLAAT
SLTGLLEKLQ SCNELLEKIM KGLNAYLEKK RLFFPRFFFL SNDEMLEILS ETKDPLRVQP
HLKKCFEGIA KLEFLPNLDI KAMYSSEGER VELIALISTS AARGAVEKWL IQVEDLMLRS
IHDVIAAARL AYPDSTRRDW VREWPGQVVL CVSQMFWTSE TQEVISDGTK GLIKYYKELQ
NQLNDIVGLV RGKLSKQTRT TLGALVTIDV HARDVVMDMI DVGVSHNTDF QWLAQLRYYW
EYENARVRII NCNVKYAYEY LGNSPRLVIT PLTDRCYRTL IGAFYLNLGG APEGPAGTGK
TETTKDLAKA LAVQCVVFNC SDGLDYLAMG KFFKGLASSG AWACFDEFNR IELEVLSVVA
QQILCIQRAI QQKLDVFVFE GAELKLNPNC FVAITMNPGY AGRSELPDNL KVLFRTVAMM
VPNYALIAEI SLYSYGFLNA KPLSVKIVMT YRLCSEQLSS QFHYDYGMRA VKAVLVAAGN
LKLKFPNENE DILLLRSIKD VNEPKFLSHD IPLFNGITSD LFPGIKLPEA DYHSAIEISW
PITSTESEEI QKYLAKSTNN CYSKLLLFLN SFMLVGEPFA AKTEVLHVLA DTLTLMHERG
YGEEEKVIYR TVNPKSITMG QLFGQFDPVS HEWTDGIVAN TFREFALSET TDRKWVVFDG
PIDTLWIESM NTVLDDNKKL CLMSGEIIQM SPQMSLIFEA MDLSQASPAT VSRCGMIYLE
PSQLGWEPLV SSWLSSLKGP LQEHENQALL RGLFDWLIWP SLRLRKKQCK INKYRVGQSR
FPVVSSNITC YLIIFYLNLY NRAALVQYTS SVYNLVFYQQ ACFMFSLIWS IGGSCDTNGR
IIFDSFLRSV MLGNIESIPV PDSVGKWECH FDEKGLVYDY MYELKNRGRW VHWNELIKST
DLGDKRIKIQ DIIVPTMDTV RYTFLMNLSI TYAKPLLFVG PTGTGKSVYV KDKLMNHLEK
NQYFPFYVNF SARTSANQVQ NIIMARLDKR RKGVFGPPMG KKCIIFIDDM NMPTLEKYGA
QPPIELLRQF FDCGNWYDLK DTSKITLVDI QLIAAMGPPG GGRNPVTPRF IRHFNICTIN
AFSDETMVRI FSSIVAFYLR TRDFPPEFFL IGNQIVSGTM EIYKQSMKNL LPTPTKSHYT
FNLRDFSRVI QGCLLIERDA VGSKHTMIRL FVHEVLRVFY DRLINDEDRY WLFNLIKVVI
KEHFKESFDS VFSHLRKENA PVTEKDLRNL MFGDYMNTDL EGDDRVYIEI PNIHQFSDIV
DQCLDEYNQT HKRRMNLVIF RYVLEHLSRI CRILKQSGGN ALLVGLGGSG RQSLTRLATS
MAKMQIFQPE ISKSYGMNEW REDMKPNELN IYTPISLENN RSKILEKRLR YLNDHFTYNL
YCNICRSLFE KDKLLFSFLL CANLLLAKKE IDYQELMFLL TGGVSLKSAE KNPDPTWLQD
KSWEEICRAS EFPAFQGLRS HFCTYIDEWQ KIYDSKEPHN AVLPEPMNQT LNELQKIIIL
RCLRPDKITP AITNYVTDKL GKKFVEPPPF DLTKSYWDSN CTIPLIFVLS PGADPMASLL
KFANDKAMTG NKFQAISLGQ GQGPIATKMI KAAIEEGTWV CLQNCHLAVS WMPMLEKICE
DFSPDVCNSS FRLWLTSYPS PKFPVTILQN GVKMTNEPPT GLRLNLLQSY LTDPISDHHF
FNGCHGKELA WEKLLFGVCF FHALVQERKK FGPLGWNIPY GFNESDLRIS IRQLQLFINE
YDTIPFEAIS YLTGECNYGG RVTDDWDRRL LLTMLADFYN THIIENPHYK FSPSGNYFAP
PRGTYNDYIE FIKKLPFTQH PEVFGLHENV DISKDLQQTK VLFESLLLTQ GGSKQTGSSG
STDQILFEIS RDILQKLPND FDIEAALLKY PVSYEESMNT VLVQEMERFN NLIKTIRSTL
QDLEKAIKGV VVMDSALEAL SGSLLVGKVP EIWAQRSYPS LKPLGSYITD FLARLNFLQD
WYDSGKPCVF WLSGFFFTQA FLTGAMQNYA RKYTIPIDLL GYEFEVIPYD KSETSPEDGV
YIHGLYLDGA RWDRPSGLLA EQYPKLLFDL MPIIWIKPNQ KDQIEKSNAY ICPLYKTSER
KGTLSTTGHS TNFVIAMLLK TDQPVQHWIK RGVALLCQLD
//
