ID G1NV90_MYOLU Unreviewed; 796 AA.
AC G1NV90;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=EMAP like 2 {ECO:0000313|Ensembl:ENSMLUP00000001176.2};
GN Name=EML2 {ECO:0000313|Ensembl:ENSMLUP00000001176.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000001176.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000001176.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000001176.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; AAPE02054008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02054009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02054010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02054011; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02054012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1NV90; -.
DR STRING; 59463.ENSMLUP00000001176; -.
DR Ensembl; ENSMLUT00000001283.2; ENSMLUP00000001176.2; ENSMLUG00000001278.2.
DR eggNOG; KOG2106; Eukaryota.
DR GeneTree; ENSGT00940000153887; -.
DR HOGENOM; CLU_011754_0_0_1; -.
DR InParanoid; G1NV90; -.
DR OMA; DVEWATA; -.
DR TreeFam; TF317832; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0072686; C:mitotic spindle; IEA:Ensembl.
DR GO; GO:0008017; F:microtubule binding; IEA:Ensembl.
DR GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR GO; GO:0031115; P:negative regulation of microtubule polymerization; IEA:Ensembl.
DR GO; GO:0010968; P:regulation of microtubule nucleation; IEA:Ensembl.
DR CDD; cd21948; TD_EMAP2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF50; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 2; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF03451; HELP; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 420..457
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REPEAT 649..690
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 761..796
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 74..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..149
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 796 AA; 86593 MW; E864370E61432949 CRC64;
MAERGPAFCG LYDTSSLLQY CNDDNLSGTS GMEVDDRVSA LEQRLQLQED ELAVLKAALA
DALRRLRACE EQGAALRARS TPKGRAPPAA FPTRTPLNGS GPPRRVGGYA TSPSSPKKEA
TSRHSLHSAR RYLSPERLAS VRREDPRSRT TSSSSNCSAK KEGPDSKTKE AIFSVEEGSV
KMFLRGRPVP MLIPDELVPT YSLDTRSELP SCRLKLDWVY GYRGRDCRAN LYLLPTGEIV
YFVASVAVLY SVEEQRQRHY LGHNDDIKCL AVHPDMVTIA TGQVAGTTKE GKPLPPHVRI
WDSVSLSTLH VLGLGVFDRA VCCVGFSKSN GGNLLCAVDE SNDHVLSVWD WTKEAKVVDS
KCTDEGPWAW WRGEVLVQGH TPVRGWGPET WVLDGGPRFG EKHEKPKYVL CVTFLEGGDV
VTGDSGGNLY VWGKGGNRIT QVVPGAHDGG VFGLCALRDG TLVSGGGRDR RVVFWGPDYS
KLQEVEVRRG RGSFKGCARA GAGNVRPVSR KRPVKSSGLA LPRLEGCVNE IFGRSVHHIP
SQCTSCGNVE QESKRIQDPQ GQEGCFLFED PARSAGFHPS GSVLAVGTVT GRYHCLPSKT
CQLTALITSR RAHPSVSSYM PTCSELPLCS ILPVLTPPPP ALTPPLASPQ GHSSFITHLD
WARDSSRFVT NSGDYEILYW DSATCKQITS ADEVRNVEWA TATCVLGFGV FGIWSEGADG
TDINAVARSH DGKLLASADD FGKVHLFSYP CCQPRAHSHK YGGHSSHVTN VAFLWDDSMA
LTTGGKDTSI LQWRVV
//
