ID G1NXV8_MYOLU Unreviewed; 1016 AA.
AC G1NXV8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Protein HIRA {ECO:0000256|ARBA:ARBA00021597, ECO:0000256|RuleBase:RU364014};
GN Name=HIRA {ECO:0000313|Ensembl:ENSMLUP00000002225.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000002225.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000002225.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000002225.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|ARBA:ARBA00007306, ECO:0000256|RuleBase:RU364014}.
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DR EMBL; AAPE02038848; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02038849; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02038850; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1NXV8; -.
DR STRING; 59463.ENSMLUP00000002225; -.
DR Ensembl; ENSMLUT00000002449.2; ENSMLUP00000002225.2; ENSMLUG00000002434.2.
DR eggNOG; KOG0973; Eukaryota.
DR GeneTree; ENSGT00550000074919; -.
DR HOGENOM; CLU_004372_0_0_1; -.
DR InParanoid; G1NXV8; -.
DR OMA; RGSWDGD; -.
DR TreeFam; TF323161; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0042393; F:histone binding; IEA:Ensembl.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006334; P:nucleosome assembly; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR011494; HIRA-like_C.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF07569; Hira; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853,
KW ECO:0000256|RuleBase:RU364014}; Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 65..97
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 126..158
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 169..200
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 763..961
FT /note="Protein HIRA-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07569"
FT REGION 489..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..555
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1016 AA; 111331 MW; 624ABA64E923E093 CRC64;
RLLSPTFILS SSKPIFSVDI HPDGTKFATG GQGQDSGKVV IWNMSPVLQE DDEKDENIPK
MLCQMDNHLA CVNCVRWSNS GMYLASGGDD KLIMVWKRAT YIGPSTVFGS SGKLANVEQW
RCVSILRSHS GDVMDVAWSP HDAWLASCSV DNTVVIWNAV KFPEILATLR GHSGLVKGLT
WDPVGKYIAS QADDRSLKVW RTLDWQLETS ITKPFDECGG TTHVLRLSWS PDGHYLVSAH
AMNNSGPTAQ IIEREGWKTN MDFVGHRKAV TVVKFNPKIF KKKQKNGSSA KPSCPYCCCA
VGSKDRSLSV WLTCLKRPLV VIHELFDKSI MDISWTLNGL GILVCSMDGS VAFLDFSQDE
LGDPLSEEEK SHIHQSTYGK SLAIMTEAQL STAVIENPEM LKYQRRQQQQ QLDQKSAVAR
ETGSAASVAG VVNGESLEDI RKNLLKKQVE TRTADGRRRI TPLCIAQLDT GDFSTAFFNS
IPLSGSLAGS MLSSHSSPQL LPLDASTPNS FGTSKPSTEP AAAAGTRPAG NSVNKDSVNA
TSAPAASSPS VLTTPSKIEP MKAFDSRFTE RSKATPGAPV LTSVTPTAVE RLKEQNLVKE
LRPRDLLESS SDSDEKVPVA KSSSLSKRKL ELEVETVEKK KKGRPRKDSR LMPMSLSVQS
PAALTAEKDT VCLSVPAPTL KLPMPGPQRA FTLQVSSDPS MYIEVENEVT AVGGVKLSRL
KCNREGKEWE TVLTSRILTA AGSCDVVCVA CEKRMLSVFS TCGRRLLPPI LLSSPISTLH
CTGSYVMALT AAATLSVWDV HRQVVVVKEE SLHSILAGSD MTVSQILLTQ HGIPVMNLSD
GKAYCFNPSL STWNLVSDKQ DSLAQCADFR SSLPPQDAML CSGPLAIVQG RASTSGRQAA
RLFSVPHVVQ QETTLAYLEN QVAAALTLQS SHEYRHWLLL YARYLVNEGF EYRLREICKD
LLGPVHYSTG SQWESTVVGL RKRELLKELL PVIGQNLRFQ RLFTECQEQL DILRDK
//
