ID G1P577_MYOLU Unreviewed; 117 AA.
AC G1P577;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Cholecystokinin {ECO:0000313|Ensembl:ENSMLUP00000005150.2};
GN Name=CCK {ECO:0000313|Ensembl:ENSMLUP00000005150.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000005150.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000005150.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000005150.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU004362}.
CC -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC {ECO:0000256|ARBA:ARBA00006273, ECO:0000256|RuleBase:RU004362}.
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DR EMBL; AAPE02044673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006102369.1; XM_006102307.2.
DR AlphaFoldDB; G1P577; -.
DR STRING; 59463.ENSMLUP00000005150; -.
DR Ensembl; ENSMLUT00000005637.2; ENSMLUP00000005150.2; ENSMLUG00000005640.2.
DR GeneID; 102417971; -.
DR KEGG; mlf:102417971; -.
DR CTD; 885; -.
DR eggNOG; ENOG502S472; Eukaryota.
DR GeneTree; ENSGT00390000003571; -.
DR HOGENOM; CLU_169783_0_0_1; -.
DR InParanoid; G1P577; -.
DR OMA; YSGLCIC; -.
DR OrthoDB; 5293435at2759; -.
DR TreeFam; TF333419; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR GO; GO:0051428; F:peptide hormone receptor binding; IEA:Ensembl.
DR GO; GO:0007586; P:digestion; IEA:InterPro.
DR InterPro; IPR015499; CCK-like.
DR InterPro; IPR001651; Gastrin/CCK.
DR InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR PANTHER; PTHR10786; CHOLECYSTOKININ; 1.
DR PANTHER; PTHR10786:SF0; CHOLECYSTOKININ; 1.
DR Pfam; PF00918; Gastrin; 1.
DR SMART; SM00029; GASTRIN; 1.
DR PROSITE; PS00259; GASTRIN; 1.
PE 3: Inferred from homology;
KW Amidation {ECO:0000256|ARBA:ARBA00022815};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..117
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003417628"
FT DOMAIN 3..114
FT /note="Gastrin/cholecystokinin peptide hormone"
FT /evidence="ECO:0000259|Pfam:PF00918"
FT REGION 19..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 74..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 117 AA; 12968 MW; B5463508399E3AAC CRC64;
MKSGVCLCVL VAALAAGTLA QPVPPPDPEG PGAQRDEEAP RRQLRAVQRV DGEPPAHLGA
LLARYIQHAR KAPSGRMSMI KNLQSRDPSH RISDRDYMGW MDFGRRSAEE EEYEYPS
//
