ID G1P7Z5_MYOLU Unreviewed; 535 AA.
AC G1P7Z5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Suppressor of cytokine signaling 6 {ECO:0000313|Ensembl:ENSMLUP00000006264.2};
GN Name=SOCS6 {ECO:0000313|Ensembl:ENSMLUP00000006264.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000006264.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000006264.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000006264.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; AAPE02022254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006090835.1; XM_006090773.2.
DR RefSeq; XP_006090836.1; XM_006090774.2.
DR RefSeq; XP_006090837.1; XM_006090775.2.
DR AlphaFoldDB; G1P7Z5; -.
DR STRING; 59463.ENSMLUP00000006264; -.
DR Ensembl; ENSMLUT00000006858.2; ENSMLUP00000006264.2; ENSMLUG00000006873.2.
DR GeneID; 102434820; -.
DR KEGG; mlf:102434820; -.
DR CTD; 9306; -.
DR eggNOG; KOG4566; Eukaryota.
DR GeneTree; ENSGT00940000154847; -.
DR HOGENOM; CLU_038160_0_0_1; -.
DR InParanoid; G1P7Z5; -.
DR OMA; TPWPLRS; -.
DR OrthoDB; 5401079at2759; -.
DR TreeFam; TF321368; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0001772; C:immunological synapse; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0050868; P:negative regulation of T cell activation; IEA:Ensembl.
DR GO; GO:0010498; P:proteasomal protein catabolic process; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0040008; P:regulation of growth; IEA:Ensembl.
DR CDD; cd10387; SH2_SOCS6; 1.
DR CDD; cd03740; SOCS_SOCS6; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035865; SOCS6_SH2.
DR InterPro; IPR037345; SOCS6_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF28; SUPPRESSOR OF CYTOKINE SIGNALING 6; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 384..491
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 486..535
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 56..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..74
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 535 AA; 59443 MW; ADEDE09A52A09E03 CRC64;
MKKISLKTFR KSFNLTKSKE EADFMVVQQP SLASDFGKED SLFGSCYGKD MASCDINGED
DKGAKNRSKS ESLMGTLKRR LSAKQKQKGK GSGPSGSSAD EDTFSSSSAP LVFKDVRAQR
PIRSTSLRNH HYSPTPWPLR PTNSEETCIK MEVRVKALVH SSSPSPALNG VRKDFHDLQS
DSVCQEQNSS LKSSESQNGD LHLHLDEHVP VVIGLMPQDY IQYTVPLEEG MYPLEGPRSY
CLDGSSPMEV SAVPPPGGGS SFPEDENQVD QELVVAPEIF VDQSVNGLLI GTTGVMLQSP
RASHDDAPPL SPLLPPLQTN PIQRNFSGIT GADAHVAESM RCHLNFDPNS APGVARVYDS
VQSSGPMVVT SLTEELKKLA KQGWYWGPIT RWEAEGKLAN VPDGSFLVRD SSDDRYLLSL
SFRSHGKTLH TRIEHSNGRF SFYEQPDVEG HTSIVDLIEH SIRDSENGAF CYSRSRLPGS
ATYPVRLTNP VSRFMQVRSL QYLCRFVIRQ YTRIDLIQKL PLPNKMKDYL QEKHY
//