ID G1P9E5_MYOLU Unreviewed; 770 AA.
AC G1P9E5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Rho guanine nucleotide exchange factor 10 {ECO:0000313|Ensembl:ENSMLUP00000006844.2};
GN Name=ARHGEF10 {ECO:0000313|Ensembl:ENSMLUP00000006844.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000006844.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000006844.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000006844.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02062123; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1P9E5; -.
DR STRING; 59463.ENSMLUP00000006844; -.
DR Ensembl; ENSMLUT00000007496.2; ENSMLUP00000006844.2; ENSMLUG00000007470.2.
DR eggNOG; KOG3522; Eukaryota.
DR GeneTree; ENSGT00940000153798; -.
DR HOGENOM; CLU_001213_4_0_1; -.
DR InParanoid; G1P9E5; -.
DR OMA; CDSHILC; -.
DR TreeFam; TF331430; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12877:SF14; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 2..189
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT COILED 172..203
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 770 AA; 85180 MW; 32BB79514BCD56BD CRC64;
VVRRYILGSI VDSEKNYVDA LTRILEQYER PLAEMEPRVL SERKLRVVFH RLREVRQCHR
LFQMALASRV AEWDAVEMIG DVFVASFSKS MVLDAYSEYV NNFSAAVAVL KKACSTKPAF
LEFLKQSQES SPDRVTLYSL MTRPIQRFPQ FILLLQDMLR NTPRGHPDRL PLQMALTELE
TLAEKLNERK RDADQRCEMK QLAKAINERY LNKLLSSGSR HLIRSDDVIE TVYNDRGEVL
KTKERRLLML TDVLMCVTVS ARTGPDSHAL LPASQRHLLK WSVPLGHVAV VEYGHPEGAA
EHPPESLAVV ANAKPHRVHV GPGQLYQDLQ NLLHDLNVVG QIAQLVGDLR GHYQNLNQAV
AHDWASGLQR LVLRKEEEIR AADCCRLQLQ LPGKQDKSGR PTFFTAVFST FTPACKESWL
SSLQMAKLAL EEDNHVGWFC VEDDGNQVKK DRHPLLLGHM PVTVAKQQEF KIECAVYNPE
PHPGRAGRPD PTGAAQGFLW IGSCTGQMGQ IAIVSFHNSN PKVIECFNVE SRILCMVHMP
AERGPQPSPA PEPGTTAGSA LGIPTVCLGT EEGSISVYKS SPGAKKVRLQ QFFTPDKATV
MSLACTPRNL YAGLVDGAVA VYAKAQDGSW DSEPHKVIKL GVLPVRSLLT AEDTLWAASG
GQVSIVSVET HAVGSQLEAH QEEGMVVSHM AIAGVGIWIA FTSGSTLRLF HTETLKHLQD
INIATPVHHM LPGNRAGPSA VRTSLLVCHD LLMSAPALGF VEALPIPRLQ
//
