ID G1PA25_MYOLU Unreviewed; 325 AA.
AC G1PA25;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Lipid droplet-associated hydrolase {ECO:0000256|ARBA:ARBA00019242};
DE AltName: Full=Lipid droplet-associated serine hydrolase {ECO:0000256|ARBA:ARBA00031924};
GN Name=LDAH {ECO:0000313|Ensembl:ENSMLUP00000007119.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000007119.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000007119.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000007119.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lipid droplet {ECO:0000256|ARBA:ARBA00004502}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. LDAH family.
CC {ECO:0000256|ARBA:ARBA00008300}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAPE02023820; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02023821; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PA25; -.
DR STRING; 59463.ENSMLUP00000007119; -.
DR Ensembl; ENSMLUT00000007795.2; ENSMLUP00000007119.2; ENSMLUG00000007792.2.
DR eggNOG; KOG3975; Eukaryota.
DR GeneTree; ENSGT00390000009688; -.
DR HOGENOM; CLU_018394_2_1_1; -.
DR InParanoid; G1PA25; -.
DR OMA; WVPVSYY; -.
DR TreeFam; TF313050; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005811; C:lipid droplet; IEA:UniProtKB-SubCell.
DR GO; GO:0016298; F:lipase activity; IEA:InterPro.
DR GO; GO:0019915; P:lipid storage; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR019363; LDAH.
DR PANTHER; PTHR13390; LIPASE; 1.
DR PANTHER; PTHR13390:SF0; LIPID DROPLET-ASSOCIATED HYDROLASE; 1.
DR Pfam; PF10230; LIDHydrolase; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Lipid droplet {ECO:0000256|ARBA:ARBA00022677};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
SQ SEQUENCE 325 AA; 37247 MW; 581424B181CF69F3 CRC64;
MNSEIKEEIP VHEEFTLCCG VETQVLKCGP WTNLFKNQSA NRPKLLIFII PGNPGFSAFY
VPFAKALYSS VNRRFPVWII SHAGHVLAPK DKKILAASDD PNAQEIKDIY GLRGQVEHKV
AFLRTHVPKE TKLVVIGHSI GSYFALQILK HAPELPIIRS FLLFPTIERM SESPNGRIAT
PFLCWLRYAL YVSSYLLLKP CPETIKSWLI RMALQRMNVQ SEFSVLSVLE PFCLANVAYL
GGQEMMQVVK RDNETIKEHL PKLTFYYGTI DAWCPTKYYE DIKKDFPEGD IRLCEKKIAH
AFILRSYQEM ADMVADWLKD DLSKV
//
