ID G1PAK9_MYOLU Unreviewed; 936 AA.
AC G1PAK9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=MORC family CW-type zinc finger 4 {ECO:0000313|Ensembl:ENSMLUP00000007325.2};
GN Name=MORC4 {ECO:0000313|Ensembl:ENSMLUP00000007325.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000007325.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000007325.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000007325.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02002845; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PAK9; -.
DR STRING; 59463.ENSMLUP00000007325; -.
DR Ensembl; ENSMLUT00000008019.2; ENSMLUP00000007325.2; ENSMLUG00000007987.2.
DR eggNOG; KOG1845; Eukaryota.
DR GeneTree; ENSGT00940000161221; -.
DR HOGENOM; CLU_011516_3_0_1; -.
DR InParanoid; G1PAK9; -.
DR OMA; YKWIVGE; -.
DR TreeFam; TF329118; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0035064; F:methylated histone binding; IEA:Ensembl.
DR Gene3D; 3.30.40.100; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR045261; MORC_ATPase.
DR InterPro; IPR041006; Morc_S5.
DR PANTHER; PTHR23336:SF22; MORC FAMILY CW-TYPE ZINC FINGER PROTEIN 4; 1.
DR PANTHER; PTHR23336; ZINC FINGER CW-TYPE COILED-COIL DOMAIN PROTEIN 3; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF17942; Morc6_S5; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 266..400
FT /note="Morc S5"
FT /evidence="ECO:0000259|Pfam:PF17942"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 531..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 727..761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 761..872
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 629..649
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 936 AA; 106006 MW; 6AC988B3C348E319 CRC64;
MLLYRGAPAG PGAPGSGLAR PGGSPQAFWI RLSTMSPRYL QSNSSSHTRP FSAIAELLDN
AVDPDVSART VFIDVEEVKN KSCLTFTDDG CGMTPHKLHR MLSFGFTDKV IKKSQCPIGV
FGNGFKSGSM RLGKDALVFT KNGGTLTVGL LSQTYLEYVQ AQAVIVPIVP FNQQNKKMII
TEDSLPSLEA ILNYSIFNSE NDLLSQFDAI PGKKGTRVLI WNIRRNKDGK SELDFDTDQF
DILVSDFGTE EKETGGVTSE LPETEYSLRA FCGILYMKPR MKIFLRQKKV TTQMIAKSLA
NVAYDIYKPT FTNKQVKITF GFSCKNNNQF GIMMYHNNRL IKPFEKVGCQ VKPTHGEGVG
VIGVIECNFL KPAYNKQDFE YTKEYRLTIN ALAQKLNVYW KEKTSQENFE TSAIARIIPK
LDDITFEGCN EDYKKRRKLP GKVDPSTLPA RWFVTIIPIP KYRRCSVPEE QELMDEDLYL
SKAKKQDQTV EKKKVPLENE DHQVFTNPLK IPTIQDMDEL NSQTIGYEEI DSPSRFPSVG
EGSKTPPLQL KPLDSSVFQF SSKYKWILGE EPVEKRRRLQ NEMTTPLDYS MPGSYRRVEA
AVAYPEGENS HDKSSSERST PPYLSPEYPD ASKSTSQSRE ASVLYSGAQE HQGSLLPEEL
EDQMPRLVAE ESNRGSTNIN KEEVNKGPFV AVVGVAKGVR DSGAPIQLIP FNREELAERR
KAAESWNPMP YPTVASATSP AAAAGEKGKG YEESGGHNTP KLKNQRELEE LKRTTEKLER
VLAERNLFQQ KVEELEQERN HWHSEFKKVQ HELVTYSTQE TEGLYWSKKH MGYRQAEFQI
LKAELERTKE EKQELKEKLK ETETHLEVLQ KAQVSYRTPE GDDLERALAK LTRLRIHVSY
LLTSVLPHLE LREIGFDSEQ VDGILYTVLE ANHILD
//
