ID G1PE78_MYOLU Unreviewed; 937 AA.
AC G1PE78;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=NACHT domain-containing protein {ECO:0000259|PROSITE:PS50837};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000008807.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000008807.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000008807.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR EMBL; AAPE02055653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PE78; -.
DR STRING; 59463.ENSMLUP00000008807; -.
DR Ensembl; ENSMLUT00000009664.2; ENSMLUP00000008807.2; ENSMLUG00000009646.2.
DR eggNOG; ENOG502RSHR; Eukaryota.
DR GeneTree; ENSGT00940000163909; -.
DR HOGENOM; CLU_002274_2_1_1; -.
DR InParanoid; G1PE78; -.
DR OMA; FPGRLAW; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR CDD; cd08320; Pyrin_NALPs; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF8; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 8; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM00368; LRR_RI; 4.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 190..321
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 937 AA; 105915 MW; 1607648EA32EC198 CRC64;
TSSSSSTSTL PSLPSFTSPF KSGVMRYMLY LSQEDLERFK QLLVREQPKA GSTQITWDQV
RTARWGEVVH LLTESFPGHL AWDMANHIFA QMDKTQLCYL TQLELQELLP HLEPTGPPPR
RALRTLEEEY SALAMGQRYR EQVLDHYFHP VDGLAWPKNQ ADFFYQDILP HQRFLPCLFL
PCRTHGRPPR TVVLRSVAGA GKTTLAHQVM LEWAGRTFYP HKAWCAFYVH CRHVVQDEEQ
SLCGLLSRQW PQAGALAAKA LARPEQLLLI LDGFEVLALP LAHRRKDLRA DWSRKLPVPI
LLASLLSGKM LPQASLLVLL RFSSWRVLKP LLSCPSVLTL SGFTAPERTR YLRRYFGDGR
AADKAVDFLR GSAIPSSMCQ APAVCWLVCL CLKEPMERGA DLFLAFPNAA ALFARHLSNA
LVAAVGGLPG TLLQECLQGA CSLAAEGMWA ARWVFGEKEL ERAQLGPEAV DALLRAHVLQ
SVVRGEARYT FVLLSFQEFF AALWYVLCFP GRFPEFQKLD RAQVRRLLAQ PSRRRNDLAH
MALFLFGLFN ETCARAVGRS FRCEVSLGNK EVLCRTALWQ DRLPTKHHGL PLLFYCLHET
REEAFLAQVL QPCKQATLMI AKHRDLQVCA FCLRCCQHLR EMQLILTLTI HKAIVTSNPD
SLLDSSLPHR PEGTNWRLCW WEELCMALAL QDLEALSLTN SVIELDAMQA LSAALKSPRC
QLHTLRVTTT MFPLLCPPHS FASVRAEEDL DHLCVCLPLT GGPEVKELPQ GMESPFFPLK
TVWLEGCSVT PGSMLEFAKD LSSNLKLKTL MVRRIYLKDE GACSLSKVQW ERLALECCDY
TLLSYRSLIL PLSSNHRLTH LSLAGNALRH EGAKDLWSAL QKAKCPLQRL VLERCQLTSD
CCQAVASLLC RHPSLRHLDL RKNDIRLRGA ELLYQTF
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