ID G1PH91_MYOLU Unreviewed; 1292 AA.
AC G1PH91;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Ion transport domain-containing protein {ECO:0000259|Pfam:PF00520};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000010034.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000010034.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000010034.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02050840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02050841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 59463.ENSMLUP00000010034; -.
DR Ensembl; ENSMLUT00000011010.2; ENSMLUP00000010034.2; ENSMLUG00000010951.2.
DR eggNOG; KOG2302; Eukaryota.
DR GeneTree; ENSGT00940000156666; -.
DR HOGENOM; CLU_000540_2_3_1; -.
DR InParanoid; G1PH91; -.
DR OMA; AGHCKSS; -.
DR TreeFam; TF313555; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR005445; VDCC_T_a1.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF192; VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1H; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 3.
DR PRINTS; PR01629; TVDCCALPHA1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 3.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1292
FT /note="Ion transport domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003417917"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 74..96
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 292..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 797..819
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 873..897
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1217..1237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1257..1282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..328
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 675..903
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1177..1292
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 388..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 935..1089
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 958..1027
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1030..1058
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1292 AA; 144018 MW; 150D20000077883D CRC64;
WFEHVSMLVI MLNCVTLGMF RPCEDVKCRS ERCSILEAFD DFIFAFFAVE MVIKMVALGL
FGQKCYLGDT WNRLDFFIVM AGYSSICPHP VFGAVAEFRG QGPLQGSAHP DSRMRILVTL
LLDTLPMLGN VLLLCFFVFF IFGIVGVQLW AGLLRNRCFL DSAFVRNNNL TFLRPYYQTE
EGDENPFICS SRRDNGMQKC SHIPSRRELR VECTLGWEAY GQLQAEGVGG ASHNACINWN
QYYNVCRSGD SNPHNGAINF DNIGYAWIAI FQGITLEGWV DIMYYVMDAH SFYNFIYFIL
LIIVGSFFMI NLCLVVIATQ FSETKQRENQ LMREQRARYL SDDSTLASFS EPGSCYEELL
KYVGHICRKV KRRSLRLYAR WQSRWCQKAD PSSPLHGQGL GHPPRRASRR AASIHHLVYH
HHHHHHHHYH FSHSSPRRPS PERGTRDTSL VRARALPSPP SPSPGPLDAE SVHSVYHADC
HVEGPQERAQ VVQAAATAAS LKLAMGLGTM NYPTILPSAP GSGKDGTSPR SKGKRASRPP
GAGGHSSLSL SSHDPYEKIQ HLVGEHGMCA CTRACTCLSV PCPLPSPQAG TLTCELKDCP
YCASALGDPE FEFSDSESGD SDGNAVYEFT QDVRHGDHRD PMQPTPVAGT PAQPGGLGHV
WATVSGKLRR IVDSKYFNRG IMMAILTNTL SMGIEYHEQP DELTNALEIS NIVFTSMFAL
EMLLKLLACG PLGYIQNPYN IFDGVIVVIS VWEIIGQADG GLSVLRTFRL LRVLKLVRFM
PALRRQLVVL MKTMDNVATF CMLLMLFIFI FSILGMHLFG CKFSLKTDTG DTVPDRKNFD
SLLWAIVTVF QILTQEDWNV VLYNGMASTS SWAALYFVAL MTFGNYVLFN LLVAILVEGF
QAEGDANRSD TDEDKTSTHL EEDFDKFRDL RATVTPNGHL EGRGSLPPPV IMRTAATPMP
TPKSSPNLDT AHGLLDSRRG SSSSVDPQLG DQKSLSSVRS SPCTPWGPNS AWSSRRSSWN
SLGRAPSLKR RSQCGERESL LSGEGKGSTD EEAEDGRPRV GASPCTRATP LRRTESLDPR
GALDTQPLRP ATLLPTKLHD CNGQMLALPS EFFLRIDSHK EDPAEFDDDM EDSCCSRLRK
VLEPYKPEWC RSREPWSLYL FSPQNRFRAS CQKIIAHKMF DHVVLVFIFL NCITIALERP
DIDPGSTERV FLNVSNYIFT AIFVAEMTVK VVALGLVSGE HAYPQSSWNV LDGLLVLVSL
VDIIVALASA GGAKILGILR VLRLLRTLRP LR
//
